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P030  Antiphospholipid syndrome and giant cell arteritis: a coincidence or connection?
Conclusion In summary, this is a case of GCA and APS, treated with prednisolone, aspirin, warfarin and tocilizumab. There is increasing evidence describing the presence of antiphospholipid antibodies in patients with vasculitis. However, the role of these antibodies in GCA and the clinical significance rema ins unclear. This case reports highlights the need for physicians to consider APS in patients who have a history of GCA and subsequently develop arterial or venous embolic events.Disclosure L. Sammut: None.E. Htut: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Stroke Care during the COVID-19 Pandemic: International Expert Panel Review
This study, prepared by a large international panel of stroke experts, assesses the rapidly growing research and personal experience with COVID-19 stroke and offers recommendations for stroke management in this challenging new setting: modifications needed for prehospital emergency rescue and hyperacute care; inpatient intensive or stroke units; posthospitalization rehabilitation; follow-up including at-risk family and community; and multispecialty departmental developments in the allied professions.Summary: The severe acute respiratory syndrome coronavirus 2 uses spike proteins binding to tissue angiotensin-converting enz...
Source: Cerebrovascular Diseases - March 23, 2021 Category: Neurology Source Type: research

Rare Cases of Thrombotic and Embolic Stroke with Hypereosinophilia (P1.295)
Conclusions:Hypereosinophilia can cause both embolic and thrombotic strokes as evidenced by our patients. The etiology of embolic stroke may be due to the direct eosinophilic damage to the endocardium or by the release of eosinophilic basic proteins which initiate endomyocardial necrosis, making the heart a potential source of emboli. Causes of thrombogenicity are multifactorial including the release of tissue factor from specific granules, inactivation of thrombomodulin by binding to the major basic protein, endothelial damage or by elevation of fibrinogen levels. The individual presentations (thrombotic/embolic) will alt...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Finelli, D., Shoamanesh, A., Perera, K. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Multiple cerebral and cerebellar infarcts as the first clinical manifestation in a patient with Churg-Strauss syndrome: case report and literature review.
CONCLUSION: Symptoms and signs of central nervous system can be the initial neurological manifestation of CSS patients. CSS should be considered while patients have stroke and hypereosinophilia. In our patient, there is a good response to timely steroid, immunosuppressant and anticoagulant therapies. PMID: 23329548 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Amyloid Beta Related Angiitis in the Setting of Anticoagulation (P2.256)
Conclusion: ABRA is a rare, but treatable cause of rapid cognitive decline. Early recognition of such a rare complication of CAA can improve outcomes through offering proper immunosuppressive treatment in a timely manner. The role of amyloid PET scan as a supportive diagnostic tool for CAA and ABRA is still to be defined.Disclosure: Dr. Costa has nothing to disclose. Dr. Albadareen has nothing to disclose. Dr. Sundararajan has nothing to disclose. Dr. Burns has received research support from Janssen, Wyeth, Pfizer, Danone, Baxter, and Lilly/Avid Radiopharmaceuticals.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Costa, C., Albadareen, R., Sundararajan, J., Burns, J. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Lateral Medullary Stroke in Patient with Granulomatous Polyangiitis
We report a 41-year-old man with lateral medullary infarction who developed rapidly progressive renal failure. He was diagnosed with GPA based on positive serum c-ANCA and antiproteinase 3 antibodies and demonstration of pauci-immune crescentic glomerulonephritis on kidney biopsy. He was treated with Coumadin, pulse steroids, cyclophosphamide, and plasmapheresis. He had resolution of his neurologic deficits and improvement in renal function. This case report highlights the importance to consider GPA vasculitis in the differential diagnosis of stroke in patients with development of acute kidney injury.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2013 Category: Neurology Authors: Olga D. Taraschenko, Colum F. Amory, Jonathan Waldman, Era K. Hanspal, Gary L. Bernardini Tags: Case Reports Source Type: research