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Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques
J Am Chem Soc. 2023 Aug 2. doi: 10.1021/jacs.3c04981. Online ahead of print.ABSTRACTAtherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition of fiber caps induced by cysteine cathepsin. However, the accurate measurement of cathepsin B (CTB) activity in plaques is challenging due to the low specificity and insufficient penetration depth of available atherosclerosis-associated cathepsin fluorescent probes, hampering reliable assessment of plaque vulnerability. To address these limitations, we added both lipophilic alkyl chain and hydr...
Source: Atherosclerosis - August 2, 2023 Category: Cardiology Authors: Yuan Ma Jinhui Shang Liuhui Liu Menghuan Li Xinyu Xu Hui Cao Li Xu Wei Sun Guosheng Song Xiao-Bing Zhang Source Type: research

A meta-analysis evaluating efficacy and safety of colchicine for prevention of major cardiovascular events in patients with coronary artery disease
ConclusionsColchicine is an effective, relatively safe drug that could be considered for the treatment of CAD. However, we need to pay attention to the increasing occurrence of non-cardiovascular mortality and infection especially pneumonia possibly caused by colchicine.Graphical abstractEfficacy and safety of colchicine for patients with CAD.CAD coronary artery disease;RCTs randomized controlled trials;OR odds ratio;MACEs major adverse cardiovascular events;ACS acute coronary syndrome;NNT number needed to treat;NNH number needed to harm
Source: Clinical Research in Cardiology - July 28, 2023 Category: Cardiology Source Type: research

Long-Term Outcomes of Bovine versus Porcine Mitral Valve Replacement: A Multicenter Analysis
CONCLUSIONS: In this multicenter analysis of patients undergoing bioprosthetic MVR, there was no difference in perioperative complications and risk of reoperation of long-term survival after matching.PMID:37426448 | PMC:PMC10328727 | DOI:10.1155/2023/2111843
Source: Cardiology Research and Practice - July 10, 2023 Category: Cardiology Authors: M Broadwin N Ramkumar D J Malenka R D Quinn C S Ross F Hirashima J D Klemperer R S Kramer G L Sardella B Westbrook A W Discipio A Iribarne M P Robich Source Type: research

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