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The impact of stroke on bone properties and muscle-bone relationship: a systematic review and meta-analysis
AbstractTo systematically review available evidence related to the characteristics of bone changes post-stroke and the relationship between various aspects of muscle function (e.g., strength, spasticity) and bone properties after stroke onset. An extensive online database search was undertaken (last search in January 2019). Articles that examined the bone properties in stroke patients were included. The quality of the studies was evaluated with the National Institutes of Health (NIH) Study Quality Assessment Tools. Publication bias of meta-analyses was assessed using the Egger ’s regression asymmetry test. The selection ...
Source: Osteoporosis International - November 12, 2019 Category: Orthopaedics Source Type: research

Physical activity participation and the risk of chronic diseases among South Asian adults: protocol for a systematic review and meta-analysis
DiscussionThis review will summarise the strength of the association between physical activity and selected chronic diseases and their markers among South Asian adults 40  years or older. The findings will provide an evidence base to guide public health policy and interventions in the South Asian region and to inform future research to address the rising burden of chronic diseases.Systematic review registrationPROSPEROCRD42018096505
Source: Systematic Reviews - October 30, 2018 Category: International Medicine & Public Health Source Type: research

Bringing Attention to Lesser-known Bone Remodeling Pathways
AbstractOsteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer and, by 2025, the number of fractures due to osteoporosis is expected to rise to nearly three million in the USA alone. Pharmacological treatments for osteoporosis are aimed at stabilizing or increasing bone mass. However, there are significant drawbacks to current pharmacological options, particularly for long-term management of this chronic condition. Moreover, the drug development pipelin...
Source: Clinical Reviews in Bone and Mineral Metabolism - September 1, 2018 Category: Internal Medicine Source Type: research

Calcium supplements associated with increased risk of cardiovascular death in men but not women
Commentary on: Xiao Q, Murphy RA, Houston DK, et al.. Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med 2013;173:639–46 Implications for practice and research Calcium supplements increase cardiovascular risk. The role of calcium supplements in the management of osteoporosis should be reconsidered. Context In 2008, a randomised controlled trial (RCT) suggested that calcium supplements might increase the risk of cardiovascular events.1 Subsequent meta-analyses of RCTs examining calcium monotherapy and calcium and v...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: Bolland, M. J., Grey, A. Tags: Primary health care, Drugs: cardiovascular system, Stroke, Diet, Ischaemic heart disease, Osteoporosis Source Type: research