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Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

Magnetic Resonance Imaging of Normal Pressure Hydrocephalus
Publication date: April 2016 Source:Seminars in Ultrasound, CT and MRI, Volume 37, Issue 2 Author(s): William G. Bradley Normal pressure hydrocephalus (NPH) is a syndrome found in the elderly, which is characterized by ventriculomegaly and deep white matter ischemia (DWMI) on magnetic resonance imaging (MRI) and the clinical triad of gait disturbance, dementia, and urinary incontinence. NPH has been estimated to account for up to 10% of cases of dementia and is significant because it is treatable by ventriculoperitoneal shunting. Patients with a known cause of chronic communicating hydrocephalus, that is, meningitis or ...
Source: Seminars in Ultrasound, CT and MRI - April 12, 2016 Category: Radiology Source Type: research

Bilateral Frontal Cerebral Infarctions Presenting as Ascending Weakness: Case Report (P1.023)
CONCLUSIONS: To our knowledge there are only a few case reports describing bilateral frontal cerebral infarctions due to a single A2 segment of the anterior cerebral artery. Bilateral cerebral infarctions should be considered in patients with symmetric weakness, especially in those with vascular risk factors who do not have features consistent with an alternative etiology. Reflexes are an important feature in distinguishing between central and peripheral lesions and should be closely monitored in these patients. Timely diagnosis will enable early delivery of thrombolytic therapy to these patients improving outcomes.Disclos...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mijalski, C., Khan, M., Silver, B. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Spinal Cord Infarction as the Initial Presentation of Systemic Lupus Erythematosus (P2.077)
CONCLUSIONS:Aggressive therapy with high dose corticosteroids and intravenous cyclophosphamide followed by oral therapy may be a successful therapeutic approach to spinal cord infarcts secondary to systemic lupus erythematosus. Study Supported by: N/ADisclosure: Dr. Michael has nothing to disclose. Dr. Hayat has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Michael, A., Hayat, G. Tags: Neurological Consequences of Autoimmune Disease Source Type: research

Progressive limbic encephalopathy: Problems and prospects
Conclusion: All patients who present with new onset neuropsychiatric symptoms need to be evaluated for sub-acute infections, inflammation, autoimmune limbic encephalitis and paraneoplastic syndrome. A repeated 20 minute EEG is a very effective screening tool to detect organicity.
Source: Annals of Indian Academy of Neurology - May 17, 2014 Category: Neurology Authors: Sadanandavalli Retnaswami ChandraRoopa SeshadriYasha ChikabasaviahThomas Gregor Issac Source Type: research

Epileptic Seizure as a Precipitating Factor of Vascular Progressive Supranuclear Palsy: A Case Report
Conclusions: vPSP is a condition that should be considered when a patient presents with a gradually progressive clinical picture suggestive of idiopathic PSP associated with neuroimaging evidence of cerebrovascular disease. The occurrence of epileptic seizures has not been reported before in vPSP but they might trigger the onset or precipitate the course of the PSP-like disorders.
Source: Journal of Stroke and Cerebrovascular Diseases - March 21, 2014 Category: Neurology Authors: Giuseppe Lanza, Maurizio Papotto, Giovanni Pennisi, Rita Bella, Raffaele Ferri Tags: Case Reports Source Type: research