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Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke
CNS Neurol Disord Drug Targets. 2021 Mar 22. doi: 10.2174/1871527320666210322115808. Online ahead of print.ABSTRACTThe gastrointestinal tract is a major organ for the body to absorb nutrients, water and electrolytes. At the same time, it is a tight barrier to resist the invasion of harmful substances and maintain the homeostasis of the internal environment. Destruction of the intestinal barrier is linked to the digestive system, cardiovascular system, endocrine system and other systemic diseases. Mounting evidence suggests that ischemic stroke not only changes the intestinal microbes, but also increases the permeability of...
Source: CNS and Neurological Disorders Drug Targets - March 22, 2021 Category: Drugs & Pharmacology Authors: Minping Wei Qin Huang Zeyu Liu Yunfang Luo Jian Xia Source Type: research

Role of Calcium Homeostasis in Ischemic Stroke: A Review.
Abstract Stroke is the second most common cause of death worldwide. It occurs due to the insufficient supply of oxygen-rich blood to the brain. It is a complex disease with multiple associated risk factors including smoking, alcoholism, age, sex, ethnicity, etc. Calcium ions are known to play a vital role in cell death pathways, which is a ubiquitous intracellular messenger during and immediately after an ischemic period. Disruption in normal calcium hemostasis is known to be a major initiator and activator of the ischemic cell death pathway. Under Ischemic stroke conditions, glutamate is released from the neurons...
Source: CNS and Neurological Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Authors: Ludhiadch A, Sharma R, Muriki A, Munshi A Tags: CNS Neurol Disord Drug Targets Source Type: research

The Toll-like Receptor Radical Cycle pathway: a new drug target in immune-related chronic fatigue.
Abstract In this review we discuss that peripheral and central activation of the Toll-like receptor 2/4 (TLR2/4) Radical Cycle may underpin the pathophysiology of immune-related chronic fatigue secondary to other medical diseases and conditions. The TLR Radical Cycle plays a role in illnesses and conditions that are disproportionately commonly comorbid with secondary chronic fatigue, including a) neuroinflammatory disorders, e.g. Parkinson's disease, stroke, depression, psychological stressors, and b) systemic disorders, e.g. (auto)immune disorders, chronic obstructive pulmonary disease, ankylosing spondylitis, ch...
Source: CNS and Neurological Disorders Drug Targets - March 17, 2015 Category: Drugs & Pharmacology Authors: Lucas K, Morris G, Anderson G, Maes M Tags: CNS Neurol Disord Drug Targets Source Type: research