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Source: Atherosclerosis
Condition: Translocation
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Total 8 results found since Jan 2013.
Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review
Front Cardiovasc Med. 2023 Aug 30;10:1250263. doi: 10.3389/fcvm.2023.1250263. eCollection 2023.ABSTRACTThe dysbiosis of the oral microbiome and vascular translocation of the periodontopathic microorganism to peripheral blood can cause local and systemic extra-oral inflammation. Microorganisms associated with the subgingival biofilm are readily translocated to the peripheral circulation, generating bacteremia and endotoxemia, increasing the inflammation in the vascular endothelium and resulting in endothelial dysfunction. This review aimed to demonstrate how the dysbiosis of the oral microbiome and the translocation of oral...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Diego F Gualtero Gloria In és Lafaurie Diana Marcela Buitrago Yormaris Castillo Paula Katherine Vargas-Sanchez Diana Marcela Castillo Source Type: research
Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease
Genes (Basel). 2023 Apr 14;14(4):915. doi: 10.3390/genes14040915.ABSTRACTHistone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a lesser extent, H2A in the cytoplasm. However, 20 min after assembly, histones lose acetylation marks. Moreover, new noncanonical functions have been described for HAT1, revealing its complexity and complicating th...
Source: Atherosclerosis - April 28, 2023 Category: Cardiology Authors: Miguel A Ortega Diego De Leon-Oliva Cielo Garcia-Montero Oscar Fraile-Martinez Diego Liviu Boaru Mar ía Del Val Toledo Lobo Ignacio Garc ía-Tuñón Mar Royuela Natalio Garc ía-Honduvilla Julia Bujan Luis G Guijarro Melchor Alvarez-Mon Miguel Ángel Alv Source Type: research
Cardiovascular Disease and Thrombosis in HIV Infection
Arterioscler Thromb Vasc Biol. 2022 Dec 1. doi: 10.1161/ATVBAHA.122.318232. Online ahead of print.ABSTRACTHIV infection has transitioned from an acute, fatal disease to a chronic one managed by antiretroviral therapy. Thus, the aging population of people living with HIV (PLWH) continues to expand. HIV infection results in a dysregulated immune system, wherein CD4+ T cells are depleted, particularly in the gastrointestinal tract, disrupting the gut epithelial barrier. Long-term HIV infection is associated with chronic inflammation through potentially direct mechanisms caused by viral replication or exposure to viral protein...
Source: Atherosclerosis - December 1, 2022 Category: Cardiology Authors: Megan V Perkins Sarah Joseph Dirk P Dittmer Nigel Mackman Source Type: research
Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India
CONCLUSIONS: In HIV-infected individuals, initiation of ART even at nadir of < 200 cells/mm3 may prevent or reverse cardiovascular disease outcomes that are easily measurable in low income countries.PMID:35581554 | DOI:10.1186/s12865-022-00498-0
Source: Atherosclerosis - May 17, 2022 Category: Cardiology Authors: Bagavathi Kausalya Shanmugam Saravanan Suresh Pallikkuth Rajendra Pahwa Shelly Rani Saini Syed Iqbal Sunil Solomon Kailapuri G Murugavel Selvamuthu Poongulali Nagalingeswaran Kumarasamy Savita Pahwa Source Type: research
Air pollution and cardiovascular disease: the Paul Wood Lecture, British Cardiovascular Society 2021
Heart. 2022 Jan 24:heartjnl-2021-319844. doi: 10.1136/heartjnl-2021-319844. Online ahead of print.ABSTRACTAir pollution is associated with up to 8.8 million excess deaths worldwide each year and is a major contributor to the global burden of disease. Cardiovascular conditions are the predominant cause for air pollution-related deaths and there is an urgent need to address the silent pandemic of air pollution on cardiovascular health. Air pollution exposure is associated with acute events like acute coronary syndrome and stroke, and with chronic conditions, such as atherosclerosis and heart failure. Several potential mechan...
Source: Atherosclerosis - January 25, 2022 Category: Cardiology Authors: Shruti S Joshi Mark R Miller David E Newby Source Type: research
Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
Front Cardiovasc Med. 2021 Nov 23;8:723886. doi: 10.3389/fcvm.2021.723886. eCollection 2021.ABSTRACTAtherosclerosis is associated with various pathological manifestations, such as ischemic heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading cause of public health concern. Atherosclerosis is an inflammatory disease characterized by endothelial dysfunction; vascular inflammation; and the deposition of lipids, cholesterol, calcium, and cellular debris within the vessel wall intima. In-depth studies of gut flora in recent years have shown that bacterial translocation and the existence of bact...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: BingYu Wang Jun Qiu JiangFang Lian Xi Yang JianQing Zhou Source Type: research
