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Condition: Hemorrhagic Stroke
Therapy: Statin Therapy
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Total 361 results found since Jan 2013.
Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model
Eur J Pharmacol. 2022 Apr 22:174973. doi: 10.1016/j.ejphar.2022.174973. Online ahead of print.ABSTRACTIntracerebral haemorrhagic (ICH) stroke is a major cause of death and disability globally, with no proper treatment available so far. Rutin, a dietary flavonoid, has shown protection against cerebral ischemic stroke due to its antioxidant and anti-inflammatory attributes. However, the efficacy of rutin against ICH stroke remained unexplored. Therefore, in the current study, we investigated the effect of rutin in an ICH stroke zebrafish larva model. The larvae were exposed to atorvastatin (1.25 μM) in system water for indu...
Source: European Journal of Pharmacology - April 26, 2022 Category: Drugs & Pharmacology Authors: Anil Kumar Rana Supriya Sharma Shiv Kumar Saini Damanpreet Singh Source Type: research
Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Stroke Prevention in Symptomatic Large Artery Intracranial Atherosclerosis Practice Advisory: Report of the AAN Guideline Subcommittee
Neurology. 2022 Mar 22;98(12):486-498. doi: 10.1212/WNL.0000000000200030.ABSTRACTBACKGROUND AND OBJECTIVES: To review treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS).METHODS: The development of this practice advisory followed the process outlined in the American Academy of Neurology Clinical Practice Guideline Process Manual, 2011 Edition, as amended. The systematic review included studies through November 2020. Recommendations were based on evidence, related evidence, principles of care, and inferences.MAJOR RECOMMENDATIONS: ...
Source: Atherosclerosis - March 22, 2022 Category: Cardiology Authors: Tanya N Turan Osama O Zaidat Gary S Gronseth Marc I Chimowitz Antonio Culebras Anthony J Furlan Larry B Goldstein Nestor R Gonzalez Julius G Latorre Steven R Mess é Thanh N Nguyen Rajbeer S Sangha Michael J Schneck Aneesh B Singhal Lawrence R Wechsler Al Source Type: research
Association between low-density lipoprotein cholesterol and cardiovascular mortality in statin non-users: a prospective cohort study in 14.9 million Korean adults
ConclusionLDL-C had U-curve associations for CVD mortality. The associations and optimal ranges differed across CVD subtypes. Women and older adults had weaker positive associations than men and younger adults. Positive associations with ischaemic heart disease and ischaemic stroke were maintained in adults aged 75 –84 years.
Source: International Journal of Epidemiology - February 26, 2022 Category: Epidemiology Source Type: research
Intracranial Hemorrhage in the TST Trial Intracranial Hemorrhage in the TST Trial
This analysis of the TST (Treat Stroke to Target) trial focuses on the possible impact of LDL-lowering statin therapy on risk of incident intracranial hemorrhage.Stroke
Source: Medscape Today Headlines - February 24, 2022 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention: A Meta-analysis of Randomized Clinical Trials
CONCLUSIONS AND RELEVANCE: This study suggests that the benefits and risks of more intensive LDL-C-lowering statin-based therapies for recurrent stroke risk reduction might be more favorable than the benefits and risks of less intensive LDL-C-lowering statin-based therapies, especially for patients with evidence of atherosclerosis.PMID:35188949 | DOI:10.1001/jamaneurol.2021.5578
Source: Atherosclerosis - February 21, 2022 Category: Cardiology Authors: Meng Lee Chun-Yu Cheng Yi-Ling Wu Jiann-Der Lee Chia-Yu Hsu Bruce Ovbiagele Source Type: research
Low-Density Lipoprotein Cholesterol Level After a Stroke
Randomized clinical trials (RCTs) of statins as the primary prevention for patients with a high serum low-density lipoprotein cholesterol (LDL-C) level and as the secondary prevention after an acute coronary event have shown that lowering serum LDL-C levels reduces the risks of myocardial infarction, stroke, and vascular death. These trials included stroke as a secondary end point but not as an entry criterion. The benefit of LDL-C lowering to reduce the risk of ischemic strokes in primary prevention trials and for patients with coronary heart disease is not necessarily seen among patients who have had a stroke. The Stroke...
Source: JAMA Neurology - February 21, 2022 Category: Neurology Source Type: research
Prognostic indicators for the onset of ischaemic versus haemorrhagic stroke in stable coronary artery disease
Medicine (Baltimore). 2021 Dec 3;100(48):e27973. doi: 10.1097/MD.0000000000027973.ABSTRACTThe incidence of stroke may be increased in patients with coronary artery disease (CAD). We aimed to investigate the specific risk factors for the development of ischaemic and haemorrhagic stroke in stable CAD patients.Patients with stable CAD were prospectively enrolled for future cardiovascular events in Taiwan. All the patients had received coronary interventions and were stable for least 1 month before enrolment. The incidence of ischaemic stroke was identified and confirmed by telephone and hospital records. Baseline characterist...
Source: Atherosclerosis - January 20, 2022 Category: Cardiology Authors: Wei-Ting Wang Tao-Cheng Wu Wei-Kung Tseng Yen-Wen Wu Tsung-Hsien Lin Hung-I Yeh Kuan-Cheng Chang Ji-Hung Wang Hsin-Bang Leu Wei-Hsian Yin Chau-Chung Wu Jaw-Wen Chen Source Type: research
Extracranial Carotid Plaque Hemorrhage Is Independently Associated With Poor 3-month Functional Outcome After Acute Ischemic Stroke-A Prospective Cohort Study
Conclusions: Extracranial carotid IPH is significantly associated with poor 3-month outcome after acute ischemic stroke and can predict the poor 3-month functional prognosis.PMID:34970212 | PMC:PMC8712340 | DOI:10.3389/fneur.2021.780436
Source: Atherosclerosis - December 31, 2021 Category: Cardiology Authors: Fengli Che Yanfang Liu Xiping Gong Anxin Wang Xiaoyan Bai Yi Ju Binbin Sui Jing Jing Xiaokun Geng Xingquan Zhao Source Type: research
Intracranial Hemorrhage in the TST Trial
CONCLUSIONS: Targeting an LDL cholesterol of <70 mg/dL compared with 100±10 mg/dL in patients with atherosclerotic ischemic stroke nonsignificantly increased the risk of ICH. Incident ICHs were not associated with low LDL cholesterol. Uncontrolled hypertension and anticoagulant therapy were associated with ICH which has important clinical implications.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01252875; EUDRACT identifier: 2009-A01280-57.PMID:34963300 | DOI:10.1161/STROKEAHA.121.035846
Source: Atherosclerosis - December 29, 2021 Category: Cardiology Authors: Pierre Amarenco Jong S Kim Julien Labreuche Hugo Charles Maurice Giroud Philippa C Lavall ée Byung-Chul Lee Marie-H élène Mahagne Elena Meseguer Norbert Nighoghossian Philippe Gabriel Steg Éric Vicaut Eric Bruckert Treat Stroke to Target Investigators Source Type: research
