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Circadian rhythm and risk of hemorrhagic transformation after acute ischemic stroke treated with intravenous thrombolysis - a systematic review
CONCLUSIONS: ICH occurred after ivT seems to follow a circadian pattern; the 18:00-00:00 time frame was the safest one, patients with AIS onset or ivT time between these hours had the lowest incidence of any ICH, including sICH. The 06:00-12:00 block was associated with the highest incidence of ICH and sICH. However, the analysis is limited by the small number of included studies and the heterogeneous findings reported. Further homogenized studies using comparable time frames and sICH definitions are needed to demonstrate this circadian pattern. The review protocol was registered in the OSF database under reference UHNF, d...
Source: CNS and Neurological Disorders Drug Targets - October 6, 2022 Category: Drugs & Pharmacology Authors: Adina Stan Hanna Dragos Stefan Strilciuc Silvina Ilut Vitalie Vacaras Angela Cozma Paul Stefan Panaitescu Horatiu Stan Dafin F Muresanu Source Type: research

Neurological consequences of COVID-19
Pharmacol Rep. 2022 Sep 30. doi: 10.1007/s43440-022-00424-6. Online ahead of print.ABSTRACTIn December 2019, cases of pneumonia caused by infection with the previously unknown severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to coronavirus disease 2019 (COVID-19), were identified. Typical manifestations of COVID-19 are fever, cough, fatigue and dyspnoea. Initially, it was thought that the mechanism of action of SARS-CoV-2 was only associated with respiratory tract invasion, but it was later revealed that the infection might involve many other organs and systems, including the central and peripheral ner...
Source: Pharmacological Reports - September 30, 2022 Category: Drugs & Pharmacology Authors: Waldemar Brola Maciej Wilski Source Type: research

Efficacy and Safety of Anticoagulants in Patients with Atrial Fibrillation and History of Falls or Risk of Falls: A Systematic Review and Multilevel Meta-Analysis
ConclusionNOACs were associated with less intracranial hemorrhages and ischemic strokes/systemic embolisms than VKAs in AF patients at risk of falls. These findings suggesting preferred use of NOACs over VKAs have clinical implications for physicians, patients and policy makers.
Source: Drug Safety - September 19, 2022 Category: Drugs & Pharmacology Source Type: research

Cerebrovascular radiological features of COVID-19 positive patients
CONCLUSIONS: Cerebrovascular diseases, which may cause severe disability and even threaten the patient's life, should be kept in mind, especially in COVID-19 patients who present with neurological symptoms.PMID:36066171 | DOI:10.26355/eurrev_202208_29535
Source: European Review for Medical and Pharmacological Sciences - September 6, 2022 Category: Drugs & Pharmacology Authors: B Petik M Akcicek M Sahin N Dag Source Type: research

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