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Calcification in high grade gliomas treated with bevacizumab
Abstract Calcification is a rare phenomenon in high grade glioma (HGG). CT scans are sensitive to mineralization but used infrequently for tumor assessment in the MRI era. The presence of calcification can be overlooked on routine MRI. Calcification may reflect chronicity and natural changes in the tumor or its milieu over time and may be accelerated by certain treatments. Calcification may have clinical significance which could signal potential risk for stroke or hemorrhage related to particular therapies; or it may be a positive prognostic factor for treatment response. The true incidence and relevance of calcif...
Source: Journal of Neuro-Oncology - May 5, 2015 Category: Cancer & Oncology Source Type: research

Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI Original Articles
Conclusions— We identified 4 novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of WMH in addition to previously proposed ischemic mechanisms.
Source: Circulation: Cardiovascular Genetics - April 21, 2015 Category: Cardiology Authors: Verhaaren, B. F. J., Debette, S., Bis, J. C., Smith, J. A., Ikram, M. K., Adams, H. H., Beecham, A. H., Rajan, K. B., Lopez, L. M., Barral, S., van Buchem, M. A., van der Grond, J., Smith, A. V., Hegenscheid, K., Aggarwal, N. T., de Andrade, M., Atkinson, Tags: Cerebrovascular disease/stroke, Genetics of Stroke, Risk Factors for Stroke, Epidemiology, Genetics of cardiovascular disease Original Articles Source Type: research

Glial fibrillary acidic protein in patients with symptoms of acute stroke : Diagnostic marker of cerebral hemorrhage.
Abstract Glial fibrillary acidic protein (GFAP) is a highly brain-specific protein that is expressed in large quantities in astrocytes and has important functions in terms of maintaining and stabilizing the cytoskeleton. Acute intracerebral hemorrhage leads to an immediate mechanical destruction of astroglial cells with the subsequent release of GFAP into the extracellular space and the bloodstream. On the other hand, necrosis, cytolysis and GFAP release does not occur before 6-12 h after symptom onset in ischemic stroke. Thus, in the early hours after stroke increased GFAP values could indicate intracerebral hem...
Source: Der Nervenarzt - July 25, 2014 Category: Neurology Authors: Foerch C, Pfeilschifter W, Zeiner P, Brunkhorst R Tags: Nervenarzt Source Type: research

Clinical application of perfusion computed tomography in neurosurgery.
Conclusions Perfusion CT provides quantitative and qualitative data that can add diagnostic and prognostic value in a number of neurosurgical disorders, and also help with clinical decision making. With emerging new technical developments in PCT, such as characterization of blood-brain barrier permeability and whole-brain PCT, this technique is expected to provide more and more insight into the pathophysiology of many neurosurgical conditions. PMID: 24266541 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 22, 2013 Category: Neurosurgery Authors: Huang AP, Tsai JC, Kuo LT, Lee CW, Lai HS, Tsai LK, Huang SJ, Chen CM, Chen YS, Chuang HY, Wintermark M Tags: J Neurosurg Source Type: research

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