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Management dilemma in a rare case of pituitary apoplexy with akinetic mutism in the setting of ruptured junctional brain aneurysm: A case report and literature review
CONCLUSION: Pituitary apoplexy with ruptured A1-Acom junction aneurysm with nonfunctioning pituitary macroadenoma is rare, and its presentation with akinetic mutism has not been reported. As there is scarce literature suggesting an association between pituitary apoplexy and ruptured aneurysm, it is challenging to comment regarding its pathogenesis. Although akinetic mutism generally has a poor prognosis, it may respond to Levodopa with a better outcome.PMID:36751455 | PMC:PMC9899474 | DOI:10.25259/SNI_942_2022
Source: Surgical Neurology International - February 8, 2023 Category: Neurosurgery Authors: Vikas Chandra Jha Mohammad Shahnawaz Alam Vivek Sharan Sinha Rahul Jain Source Type: research

Extracellular Vesicles in the Treatment of Parkinson's Disease: A Review.
CONCLUSION: PD is a heterogeneous disease that can be treated by using pharmacologic approaches (e.g., dopamine agonists and levodopa) and nonpharmacologic approaches (e.g., music), based on symptoms and progression level in patients. Even though current treatments have demonstrated effectiveness, clinical challenges remain because the BBB reduces medication received and lowers the efficacy of drug delivery, which impairs the treatment's effect. Therefore, EVs, as an emerging delivery platform, are highly promising for PD treatment since they can readily cross the BBB with high therapeutic efficiency through the loading or...
Source: Current Medicinal Chemistry - January 13, 2021 Category: Chemistry Authors: Yang X, Ma Y, Xie H, Dong S, Rao G, Yang Z, Zhang J, Wu Q Tags: Curr Med Chem Source Type: research