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A Chinese female patient with LGI1 and mGluR5 antibodies: A case report
We present a case of AE with dual seropositive antibodies of LGI1 and mGluR5 in a 65-year-old woman who presented with sudden onset left faciobrachial dystonic seizures and unresponsive for 5 hours. Diagnosis: The patient was diagnosed with anti-LGI1 AE and anti-mGluR5 AE mainly based on the clinical symptoms and further test of the antibody in serum and cerebral spinal fluid (CSF). Interventions and outcomes: The patient was treated with glucocorticoid intravenous drip. We also gave her the therapy of immunoglobulin (25 g q.d) for 5 days and anti-epileptic therapy. She had no more convulsions on the left s...
Source: Medicine - October 28, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis
DiscussionIn this preliminary study of six patients, we demonstrate an ASL hyperperfusion pattern, with a possible predilection for the right mesial temporal lobe on both qualitative and quantitative assessments in patients with seropositive LGI1. Larger scale studies are necessary to further characterize the strength of these associations.
Source: Frontiers in Neurology - July 28, 2022 Category: Neurology Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Mitochondrial Encephalopathy with Lactic Acidosis and Stroke (MELAS) presenting as an apparent neoplastic process (P5.015)
CONCLUSION: MELAS can mimic more common disorders. The slow onset of her symptoms and the MRI's appearance led to suspicion for neoplasm. This is the first report to our knowledge where MELAS has presented as such. Documentation of this and other unusual presentations of mitochondrial disease is crucial to appropriate diagnosis of the condition.Disclosure: Dr. Rothstein has nothing to disclose. Dr. Haq has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Rothstein, A., Haq, I. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology ePosters Source Type: research