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As some hail new antibody treatment for Alzheimer ’s, safety and benefit questions persist
In a packed San Francisco conference room with a celebratory atmosphere, upbeat company representatives and scientists yesterday presented detailed clinical trial data on the first Alzheimer’s treatment shown to clearly, albeit modestly, slow the disease’s normal cognitive decline. The antibody therapy has buoyed a field marked by decades of failures. Now, it appears to be on the cusp of being greenlit by the U.S. Food and Drug Administration (FDA). Yet other researchers warn of potential risks, including brain swelling and brain hemorrhages that were linked to the recently disclosed deaths of two trial participants wh...
Source: Science of Aging Knowledge Environment - December 1, 2022 Category: Geriatrics Source Type: research

MRI shows that brain health is linked to cardiovascular health
Yale researchers have found that adults between the ages of 40 and 69 with health...Read more on AuntMinnie.comRelated Reading: MRI shows sex differences in concussed children MRI shows that PTSD from 9/11 attacks affects cognitive ability Imaging biomarkers can help transform stroke prevention Loneliness increases dementia risk 3-fold Heart-healthy adults have healthier brains on MRI scans
Source: AuntMinnie.com Headlines - May 27, 2022 Category: Radiology Source Type: news

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Truth, And The Tribulations Of Randomized Diet Trials
This study has not been done. This study will not be done. Whatever you do, don’t hold your breath waiting for it.But, so what?Let’s contrast our ostensible need for this RCT to how we know what we know about putting out house fires.First, there has never been, to the best of my knowledge, a RCT to show that water is a better choice than gasoline. Do you think we need such a trial, to establish the legitimacy of the basic theme (i.e., use water) of the “right” approach? Would you, and your home, be willing to participate in such a trial when you call 911- knowing you might randomly be assigned to the gasoline a...
Source: Healthy Living - The Huffington Post - February 17, 2017 Category: Consumer Health News Source Type: news

CNS Summit 2016 Abstracts of Poster Presentations
Conclusion: Subjects with acutely exacerbated schizophrenia who were eligible for discharge from the inpatient setting and who completed the study demonstrated high rates of adherence using the mobile AI application. Subjects were able to easily use the technology. Use of the platform did not appear to increase the dropout rate. This study demonstrates the feasibility of using AI platforms to ensure high adherence, provide reliable adherence data, and rapidly detect nonadherence in CNS trials. Disclosures/funding: Adam Hanina and Laura Shafner are employees of AiCure, New York, New York, and consultants to Takeda. Xinxin D...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Devices Drug Development Evaluations Genetics Medical Issues Neurology Patient Assessment Proceedings Psychiatry Psychopharmacology Scales Supplements Technology Trial M Source Type: research

Declines In Dementia: Of Hearts And Minds
In this season when we are meant to be thankful, but when so many of us have had so many reasons to be otherwise, we have received a timely, welcome bit of universally good news. Rates of dementia in the United States appear to be declining. This news reaches us courtesy of a study published recently in JAMA Internal Medicine. The investigators used standard, validated measures of cognitive function and dementia in two groups of more than 10,000 people in the U.S. with an average age of roughly 75 in the year 2000, and again in 2012. The overall rate of dementia declined over that span from 11.6% to 8.8%. Taking ...
Source: Science - The Huffington Post - November 27, 2016 Category: Science Source Type: news

Public Health and Citizens, Truly United
There are just two problems with the prevailing conception of "public health" -- the public, and health. Neither means what we think it means. For starters, there is no public. The public is an anonymous mass, a statistical conception, nameless, faceless, unknowable, and unlovable. I have made the case before that laboring under this crippling fiction, the potential good that all things "public health" might do is much forestalled. We talk, for instance, about the genuine potential to eliminate up to 80 percent of the total global burden of chronic disease -- heart disease, cancer, stroke, diabetes, dementia -- but somehow...
Source: Healthy Living - The Huffington Post - March 3, 2016 Category: Consumer Health News Source Type: news

Health Lunacy and Rocket Science
The failure to use what we have known for more than two decades to prevent up to 80 percent of all major chronic disease -- heart disease, cancer, stroke, diabetes, dementia -- is costing virtually every one of us years lost from lives we love, and life lost from years. Since this is all entirely fixable with knowledge long at our disposal, the calamity of it all is, in a word, lunacy. Of course, in the vernacular, that just means crazy. But the origins of the word point to the moon. And reflections on the moon, as it turns out, could prove... illuminating. There are footprints on the moon for three basic reasons. First,...
Source: Healthy Living - The Huffington Post - July 1, 2015 Category: Consumer Health News Source Type: news

Rethinking Retirement in the 21st Century
Conclusion In the 21st century, many seniors are not retiring from something. Instead, retirement is an opportunity for reinventing, reimagining and reconnecting to one's self, family, friends and community. Robert Browning once wrote, "Grow old along with me! The best is yet to be." By investing in your physical, mental and financial health today, you can help ensure that your best years are just ahead. Rear Admiral Susan Blumenthal, M.D., M.P.A. (ret.) is the Public Health Editor of The Huffington Post. She is a Senior Fellow in Health Policy at New America and a Clinical Professor at Tufts and Georgetown University Sc...
Source: Healthy Living - The Huffington Post - May 1, 2015 Category: Consumer Health News Source Type: news

Cholesterol, Unscrambled
There seems to be a whole lot of passion in response to the recent disclosure that this year's Dietary Guidelines Advisory Committee is recommending we stop fretting about cholesterol. Note that the committee merely advises, so these are not yet the official dietary guidelines for Americans. Famously, the politicians have the final say there. That passion over cholesterol runs in both directions, with enthusiasts of more animal food intake -- Paleo, dieters, for instance -- feeling vindicated; and my vegan friends contending that an excess of cholesterol must have scrambled the brains of the Advisory Committee members, a...
Source: Healthy Living - The Huffington Post - February 17, 2015 Category: Consumer Health News Source Type: news