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Anticholinergic Burden and Cognitive Impairment in Nursing Homes: A Comparison of Four Anticholinergic Scales
ConclusionsThe cumulative effect of medications with modest antimuscarinic activity may influence the cognitive performance of NH residents. The anticholinergic burden measured with the ACB scale should help identify NH residents who may benefit from reducing the anticholinergic burden.A clear direct relationship between anticholinergic burden and cognitive impairment was found only for the ACB Scale.
Source: Drugs and Aging - August 24, 2023 Category: Geriatrics Source Type: research

Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients
Conclusions In this large ‘real-world’ cohort, outcomes after mechanical thrombectomy were strongly associated with age. Of patients aged ≥80 years more than half were dead and less than one-fifth were functionally independent at 1 year. Certain comorbidities and ventilation >48 hours were associated with even worse outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2023 Category: Neurosurgery Authors: Beuker, C., Köppe, J., Feld, J., Meyer, C. L., Dröge, P., Ruhnke, T., Günster, C., Wiendl, H., Reinecke, H., Minnerup, J. Tags: Open access Cerebrovascular disease Source Type: research

Occupational therapy for persons with cognitive impairments
CONCLUSIONS: Based on this systematic overview, it can neither be proven nor excluded with certainty that occupational therapy for cognitive impairment is an effective therapy for adult patients with central nervous system injuries compared to no occupational therapy. There is a lack of randomised trials with sufficient sample size, well-defined interventions, and comparable concomitant therapies in the control groups, but there is also a lack of well-designed observational studies in routine care and health economic studies. The identified systematic reviews on patient and social aspects provide information on the needs o...
Source: GMS German Medical Science - June 1, 2023 Category: General Medicine Authors: Petra Schnell-Inderst Annette Conrads-Frank Igor Stojkov Cornelia Krenn Lisa-Maria Kofler Uwe Siebert Source Type: research

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