Prevention of inadvertent perioperative hypothermia - Guideline compliance in German hospitals.
This study was conducted to investigate the acceptance of the recommendations of the German S3 Guideline, in particular with respect to the concept of pre-warming and sublingual temperature measurement. The main focus was to gather data concerning the postoperative core temperature and the frequency of perioperative hypothermia in patients receiving a pre-warming regime and those without. The study team investigated the local concept and measures employed to avoid inadvertent perioperative hypothermia with respect to defined outcome parameters following a specific protocol. In summary, the study hospitals vary greatly in t...
Source: GMS German Medical Science - September 18, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Poor, old and in need of care: A qualitative study about the consequences for home care and participation.
Conclusion: The results indicate how older people in need of care impose self-restrictions due to their poverty, which are harmful to health and limit the quality of life. Furthermore, the described strategies can pose a significant risk to the medical safety of patients. This has implications for the nursing and social care, but also for the medical treatment of the affected patients. The existing support systems seem to be only partially prepared for dealing with such situations. In view of a trend towards an older population structure, future research should put more emphasis on the user-friendly adaptation of the socia...
Source: GMS German Medical Science - September 18, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Management of pain in individuals with spinal cord injury: Guideline of the German-Speaking Medical Society for Spinal Cord Injury.
Discussion: Assessment of SCI-related pain is standardized and respective methods in terms of examination, classification and grading of pain are already in use and validated in German language. In contrast, valid, evidence-based and efficient therapeutic options are limited and ask for further clinical studies, ideally randomized controlled trials and meta-analyses. PMID: 31354397 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - July 30, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Continuous chest compressions with a simultaneous triggered ventilator in the Munich Emergency Medical Services: a case series.
Conclusions: Continuous chest compressions using a mechanical chest compression device and simultaneous synchronized ventilation using an oxygen-powered resuscitator in an automatic triggering mode might be feasible during cardiopulmonary resuscitation. PMID: 31354398 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - July 30, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

A close look at lay-led self-management programs for chronic diseases and health care utilisation: A systematic review and meta-analysis.
Conclusion: Although the statistically significant effects of the meta-analysis are low, our overall findings show that only a small number of the included studies tackled the task of comprehensively investigating self-management skills in the context of health care utilisation. This fails to do justice to the potential of self-management programs. It is essential to consider the appropriateness of health care utilisation. We propose the term self-management-sensitive utilisation for this purpose. PMID: 31148954 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - June 5, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

National survey of evaluation practices and performance-guided resource allocation at German medical schools.
Conclusion: A nationwide agreement on a generalizable definition of high-quality teaching is desirable. At the same time, reliable and valid tools measuring teaching quality need to be identified and/or created. This could be accomplished through a wider collaboration of medical schools and could represent an advancement for the allocation of resources for high-quality teaching. PMID: 31148955 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - June 5, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Automated sleep stage classification based on tracheal body sound and actigraphy.
Authors: Kalkbrenner C, Brucher R, Kesztyüs T, Eichenlaub M, Rottbauer W, Scharnbeck D Abstract The current gold standard for assessment of most sleep disorders is the in-laboratory polysomnography (PSG). This approach produces high costs and inconveniences for the patients. An accessible and simple preliminary screening method to diagnose the most common sleep disorders and to decide whether a PSG is necessary or not is therefore desirable. A minimalistic type-4 monitoring system which utilized tracheal body sound and actigraphy to accurately diagnose the obstructive sleep apnea syndrome was previously develo...
Source: GMS German Medical Science - April 20, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever.
Authors: Blumentrath CG, Müller G, Teichmann D, Tiesmeier J, Petridou J Abstract In times of emerging multi-drug resistance among Gram-negative bacteria (including Salmonella enterica, Serovar Typhi), we observed relapse of typhoid fever following delayed response to treatment with meropenem, suggestive for limited clinical efficacy of the drug. Three previously published cases supported our suspicion. Within this context, we discuss the case details with a focus on potential explanations for insufficient clinical response to meropenem (e.g. limited intracellular penetration, phenomena of tolerance and persist...
Source: GMS German Medical Science - March 8, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Evaluation of a Master of Science in Integrated Clinical and Community Mental Health (MSc ICCMH) program in Ethiopia.
Conclusions: The outcome of the program is a considerable workforce of skilled mental health professionals. The majority of graduates were retained within the public mental health service. Brain drain does not appear to be a challenge among non-physician mental health specialists. The findings on the self-perceived competencies mirror the amount of clinical exposure during the training. With a minimal revision of the curriculum, the level of satisfaction and competencies can be enhanced. PMID: 30627083 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - January 12, 2019 Category: General Medicine Tags: Ger Med Sci Source Type: research

Prevalence and treatment of sexually transmitted infections in men followed by urologists in Germany - a cross sectional study with 347,090 men.
Conclusions: Overall, approximately 1.25% of men followed in urology practices in Germany between 2013 and 2015 were diagnosed with at least one STI. Further research is needed to gain a better understanding of the factors potentially associated with the risk of being diagnosed with STI in this setting in Germany. Moreover, there is a need for enabling higher rates of diagnosis and thus treatment of infected persons. PMID: 30250416 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - September 28, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Treatment of ambulant patients by a general practitioner within a university hospital's emergency department - follow-up study of patients' behaviour shortly afterwards.
Conclusion: A noteworthy number of patients considered visiting the ED again with similar symptoms instead of visiting a GP in ambulatory care. Consequently our findings suggest that the ED itself plays a minor role in navigating patients' utilisation of medical treatment. PMID: 30022895 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - July 20, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Real world data in health technology assessments in kidney transplants in Germany: use of routinely collected data to address epidemiologic questions in kidney transplants in the AMNOG process in Germany.
Authors: Herrmann KH, Meier-Kriesche U, Neubauer AS Abstract Introduction: It is discussed whether real world data can be used in health technology assessment. Following it is of interest whether routinely collected data for quality assurance (QA) in the hospital sector is feasible to address epidemiologic questions in kidney transplantation in the AMNOG process in Germany. Objectives: To investigate the proportion of kidney transplants classified as from so-called standard criteria donors (SCD) and from expanded criteria donors (ECD) in Germany and to study the age distribution. Methods: After granted use by the F...
Source: GMS German Medical Science - February 25, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Parathyroid carcinoma: an unusual presentation of a rare neoplasm.
We report a case of a 31-year-old woman who presented with renal colic. Various hematological, biochemical and radiological investigations were performed and a slightly enlarged right parathyroid was found. A clinical diagnosis of parathyroid adenoma was made and a right parathyroidectomy was done. Intraoperatively the surgeon had no suspicion of malignancy but microscopically the lesion was malignant and a final diagnosis of parathyroid carcinoma was rendered based on the criteria of invasion. Since there is no gold standard, a multidisciplinary approach, including the entire clinical, biochemical, radiological and pathol...
Source: GMS German Medical Science - January 23, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Transition from in-hospital ventilation to home ventilation: process description and quality indicators.
Authors: Kastrup M, Tittmann B, Sawatzki T, Gersch M, Vogt C, Rosenthal M, Rosseau S, Spies C Abstract The current demographic development of our society results in an increasing number of elderly patients with chronic diseases being treated in the intensive care unit. A possible long-term consequence of such a treatment is that patients remain dependent on certain invasive organ support systems, such as long-term ventilator dependency. The main goal of this project is to define the transition process between in-hospital and out of hospital (ambulatory) ventilator support. A further goal is to identify evidence-bas...
Source: GMS German Medical Science - January 10, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Risk factors for ectopic pregnancy in Germany: a retrospective study of 100,197 patients.
Conclusions: Prior ectopic pregnancy and prior genital surgery were strongly associated with ectopic pregnancy in women followed in German gynecological practices. Psychiatric diseases had an additional impact on the risk of ectopic pregnancy. PMID: 29308062 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - January 10, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Cone-beam tomographic analysis of canalis sinuosus accessory intraosseous canals in the maxilla.
Authors: Ghandourah AO, Rashad A, Heiland M, Hamzi BM, Friedrich RE Abstract The aim of this study was to assess the frequency, location and width of accessory canals (AC) of canalis sinuosus (CS) using cone beam computed tomography and compare our findings with recent literature. Additionally, intraosseous canals (IOC) in the sinus wall other than the CS were noted. A retrospective analysis of 219 scans from our university department was conducted. The registered parameters were age, sex, location and width of canals. Group A consisted of 201 (85 males and 116 females) adults ranged from 19 to 99 years of age (mea...
Source: GMS German Medical Science - January 10, 2018 Category: General Medicine Tags: Ger Med Sci Source Type: research

Matrix-producing metaplastic breast carcinoma - a rare tumor with heterologous elements.
Authors: Shruti S, Siraj F Abstract Metaplastic breast carcinomas are ductal carcinomas that undergo metaplasia into non-glandular growth patterns. They are very rare and account for less than 1% of all invasive breast carcinomas. Matrix-producing carcinoma is an extremely rare and aggressive subtype of metaplastic breast carcinoma that is characterized by a ductal carcinomatous component with direct transition to areas with cartilaginous/osseous differentiation without an intervening spindle cell element. It has a better prognosis than metaplastic carcinoma. Even though these tumors are composed of a mixture of in...
Source: GMS German Medical Science - December 21, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Genetic alterations in benign prostatic hyperplasia patients.
Conclusion: In this study, we discussed important genetic markers in benign prostatic hyperplasia patients which may, in the future, be used as markers for diagnosis and prognosis, as well as targets for therapeutic intervention. PMID: 29234244 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - December 14, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

A comparison of medical education in Germany and the United States: from applying to medical school to the beginnings of residency.
Authors: Zavlin D, Jubbal KT, Noé JG, Gansbacher B Abstract Both Germany and the United States of America have a long tradition of science and medical excellence reaching back as far as the nineteenth century. The same tribute must be paid to the medical educational system in both countries. Despite significant initial similarities and cross-inspiration, the paths from enrolling in a medical university to graduating as a medical doctor in Germany and the US seem to have become much different. To fill a void in literature, the authors' objective therefore is to delineate both structures of medical education i...
Source: GMS German Medical Science - October 21, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society.
Authors: Hofmann H, Fingerle V, Hunfeld KP, Huppertz HI, Krause A, Rauer S, Ruf B, Consensus group Abstract This guideline of the German Dermatology Society primarily focuses on the diagnosis and treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from 22 German medical societies and 2 German patient organisations. It is the first part of an AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.) interdisciplinary guideline: "Lyme Borreliosis - Diagnosis and Treatment, development stage S3". The guideline is directed at physicians in private...
Source: GMS German Medical Science - September 27, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Bilateral rhabdoid meningioma mimicking glioma: an unusual occurrence.
We describe a fifty-year-old male with headache, weakness of limbs, and altered sensorium. CT showed hetero-dense enhancing mass lesions in both right and left parietal areas raising suspicion of high grade glioma. Histopathologic and immunohistochemical examination revealed a tumor with features of rhabdoid meningioma. A review of literature did not reveal any bilateral occurrence of this tumor. PMID: 28860959 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - September 3, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Frequency and trends of hospital treated pesticide poisonings in Germany 2000-2014.
Conclusions: This study shows that the decrease of pesticide poisonings in Germany applies to fatal and non-fatal incidents. There seems to be a decrease also in the case fatality ratio which might point to positive preventive effects by reducing the availability of toxic pesticides. Fatal pesticides poisonings prevails in elder men while non-fatal pesticide poisoning more often affects the younger population. These different patterns should be addressed when improving preventive strategies. The discrepancy between the different data bases with respect to fatal poisoning might be explained by intoxications not admitted to ...
Source: GMS German Medical Science - September 3, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Quality indicators in intensive care medicine for Germany - third edition 2017.
Authors: Kumpf O, Braun JP, Brinkmann A, Bause H, Bellgardt M, Bloos F, Dubb R, Greim C, Kaltwasser A, Marx G, Riessen R, Spies C, Weimann J, Wöbker G, Muhl E, Waydhas C Abstract Quality improvement in medicine is depending on measurement of relevant quality indicators. The quality indicators for intensive care medicine of the German Interdisciplinary Society of Intensive Care Medicine (DIVI) from the year 2013 underwent a scheduled evaluation after three years. There were major changes in several indicators but also some indicators were changed only minimally. The focus on treatment processes like ward rounds...
Source: GMS German Medical Science - August 12, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Water-filtered infrared-A (wIRA) overcomes swallowing disorders and hypersalivation - a case report.
Conclusion: Besides in a variety of other indications for wIRA, in cases of swallowing disorders (functional dysphagia) and hypersalivation or hypersecretion of mucus the use of wIRA should be considered as part of the treatment regime for improving a patient's quality of life. PMID: 28794695 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - August 12, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Real life pharmaceutical treatment patterns for adult patients with focal epilepsy in Germany: a longitudinal and cross-sectional analysis of recently approved anti-epileptic drugs.
Conclusions: Most patients aged 16 years or older, suffering from focal seizures, received AED monotherapy. Novel AEDs were prescribed in a small proportion of patients (
Source: GMS German Medical Science - June 25, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Interventions for reducing self-stigma in people with mental illnesses: a systematic review of randomized controlled trials.
Conclusions: The effectiveness of interventions against self-stigma is uncertain. Previous studies lacked statistical power, used questionable outcome measures and had a high risk of bias. Future studies should be based on robust methods and consider practical implications regarding intervention development (relevance, implementability, and placement in routine services). PMID: 28496396 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - May 14, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Conflicts at work are associated with a higher risk of cardiovascular disease.
Authors: Jacob L, Kostev K Abstract Background: Only few authors have analyzed the impact of workplace conflicts and the resulting stress on the risk of developing cardiovascular disorders. The goal of this study was to analyze the association between workplace conflicts and cardiovascular disorders in patients treated by German general practitioners. Methods: Patients with an initial documentation of a workplace conflict experience between 2005 and 2014 were identified in 699 general practitioner practices (index date). We included only those who were between the ages of 18 and 65 years, had a follow-up time of at...
Source: GMS German Medical Science - May 14, 2017 Category: General Medicine Tags: Ger Med Sci Source Type: research

Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults: recognition, diagnosis, acute and long-term treatment.
Authors: Blumentrath CG, Dohrmann B, Ewald N Abstract The cannabinoid hyperemesis syndrome (CHS) and the cyclic vomiting syndrome in adults (CVS) are both characterized by recurrent episodes of heavy nausea, vomiting and frequently abdominal pain. Both syndromes are barely known among physicians. Literature is inconsistent concerning clinical features which enable differentiation between CVS and CHS. We performed a literature review using the LIVIVO search portal for life sciences to develop a pragmatic approach towards these two syndromes. Our findings indicate that complete and persistent resolution of all sympto...
Source: GMS German Medical Science - April 14, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

A comprehensive approach in high-grade glioma management: position statement from the Neuro-Oncology Scientific Club (NOSC), Shiraz, Iran.
Authors: Ansari M, Mosalaei A, Ahmadloo N, Rasekhi A, Geramizadeh B, Razmkon A, Anvari K, Afarid M, Dadras A, Nafarieh L, Mohammadianpanah M, Nasrolahi H, Hamedi SH, Omidvari S, Nami M Abstract Establishing a robust teamwork model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the comprehensive approach across involved disciplines in the management of central nervous system (CNS) malignancies. With its provincial founding panels and national steering board, NOSC has been operational...
Source: GMS German Medical Science - March 23, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Myeloid sarcoma: a report of four cases at unusual sites.
Conclusion: Although MS is associated with AML, it can rarely present without any existent hematologic disease. Differential diagnosis of a soft tissue mass should include MS even in the absence of leukemia. Establishment of the correct diagnosis depends on morphologic, histochemical, and immunohistochemical examination. PMID: 28243188 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - March 1, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany.
Conclusion: Overall, a significant association was found between AMD and depression, anxiety, adjustment disorders, and somatoform disorders. PMID: 28243189 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - March 1, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Current practice and perspectives in CRO oversight based on a survey performed among members of the German Association of Research-Based Pharmaceutical Companies (vfa).
This study shows that the majority of companies apply a full-outsourcing, preferred-provider model of clinical trial services, with the clinical research department playing the major role in this process. A large amount of guiding documents, processes and tools are used to ensure an adequate oversight of the services performed by the CRO(s). Finally the guiding principles for all oversight processes should be transparent communication, a clearly established expectation for quality, a precise definition of accountability and responsibility while avoiding silo mentality, and a comprehensive documentation of the oversight's e...
Source: GMS German Medical Science - February 8, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

The prevalence of chronic pain in orchestra musicians.
Conclusions: These results appear conclusive and indicate a need to continue research into chronic pain in musicians. PMID: 28149258 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - February 3, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

TST36 stapling for rectocele and hemorrhoidal prolapse - early results of the prospective German multicenter study.
Conclusions: Despite a notable complication rate during surgery and the postoperative period, the TST36 can be considered as an effective tool for low rectal stapling for anorectal prolapse causing hemorrhoids or obstructed defecation. PMID: 28066159 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - January 12, 2017 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Quality of care in patients with atrial fibrillation in primary care: a cross-sectional study comparing clinical and claims data.
Conclusion: Our results suggest that a high rate of AF patients receive a drug therapy according to guidelines. There is a large difference between crude and adjusted OAC treatment rates. This is due to individual contraindications and comorbidities which cannot be documented using ICD coding. Therefore, quality indicators based on crude EMR data or claims data would lead to a systematic underestimation of the quality of care. A possible overtreatment of low-risk patients cannot be ruled out. PMID: 27980520 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - December 18, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Refractory myasthenia gravis - clinical profile, comorbidities and response to rituximab.
Conclusion: The refractory MG patients are most commonly female with an early age of onset, anti-MuSK antibodies, and thymomas. Refractory MG patients have higher prevalence and poor control (HbA1C>8%) of diabetes mellitus and dyslipidemia probably due to increased steroid usage. Rituximab is very efficient in treatment of refractory MG with adverse effects being low. PMID: 27790079 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - October 31, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Solitary Langerhans cell histiocytosis of the hard palate: a diagnostic pitfall.
We present a case of a 45-year-old male who presented with an ulcer on the hard palate showing histopathologic features of LCH. The present case is a reminder of the possibility of occurrence of this unusual entity in the oral cavity. Appropriate use of immunohistochemistry is advocated to avoid diagnostic pitfalls. PMID: 27703428 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - October 7, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

The sword of Damocles for the splenectomised: death by OPSI.
Authors: Blumentrath CG, Ewald N, Petridou J, Werner U, Hogan B Abstract The overwhelming post splenectomy infection (OPSI) in splenectomised patients is a rare but severe infection mostly caused by encapsulated bacteria. We analyse the case of a 65-year-old female patient who was presented with clinical and laboratory findings indicating gastroenteritis. Two years years before admission, the patient underwent a splenectomy for a two stage splenic rupture following resuscitation for pulmonary embolism. Immunisation of the patient was complete and timely. As a result of the unspecific clinical presentation, there wa...
Source: GMS German Medical Science - September 11, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Evidence mapping for decision making: feasibility versus accuracy - when to abandon high sensitivity in electronic searches.
CONCLUSIONS: Evidence mapping with the intention of gaining an overview of a research field does not require high level accuracy in contrary to systematic reviews. Keeping this distinction in mind, a mass of extraneous information will be avoided by using specific instead of highly sensitive search strategies. PMID: 27499726 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - August 10, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Sellar reconstruction without intrasellar packing after endoscopic surgery of pituitary macroadenomas is better than its reputation.
CONCLUSIONS: There is no difference in the incidence of postoperative CSF leakage and empty sella syndrome among the various reconstructive techniques with and without intrasellar packing, irrespective of size and extension of the pituitary adenoma. Sellar reconstruction without intrasellar packing following a standard EETS is not inferior to other techniques with packing and even shows more radiological advantages, which made it our preferred technique, at least if no intraoperative CSF leakage is evident. PMID: 27408609 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - July 15, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Heat for wounds - water-filtered infrared-A (wIRA) for wound healing - a review.
Authors: Hoffmann G, Hartel M, Mercer JB Abstract BACKGROUND: Water-filtered infrared-A (wIRA) is a special form of heat radiation with high tissue penetration and a low thermal load to the skin surface. wIRA corresponds to the major part of the sun's heat radiation, which reaches the surface of the Earth in moderate climatic zones filtered by water and water vapour of the atmosphere. wIRA promotes healing of acute and chronic wounds both by thermal and thermic as well as by non-thermal and non-thermic cellular effects. METHODS: This publication includes a literature review with search in PubMed/Medline for &qu...
Source: GMS German Medical Science - July 15, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Impact of caesarean section on mode of delivery, pregnancy-induced and pregnancy-associated disorders, and complications in the subsequent pregnancy in Germany.
CONCLUSION: Women with CS were more likely to undergo further CS and to develop major pregnancy-associated diseases in the following pregnancy compared to women with VD. PMID: 27346991 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - June 28, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Switching to instant black coffee modulates sodium selenite-induced cataract in rats.
Authors: El Okda EA, Mohamed MM, Shaheed EB, Abdel-Moemin AR Abstract The influence of daily consumption of some common beverages on the development of cataract in rats was investigated. Total phenol content was determined in the beverages and an oral standardized dose of total phenols from each beverage was given to the treated rats. Weaned male albino rats were used and divided into five groups (n=7). Rats were fed Ain 93G and administered the standardized dose of instant coffee, black tea and hibiscus beverages for 30 days. On day 14 all rats were injected with a single dose of sodium selenite (Na2SeO3) 15 &micr...
Source: GMS German Medical Science - May 10, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Effect of chaetocin on renal cell carcinoma cells and cytokine-induced killer cells.
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine the effects of chaetocin with the effects of cytokine-induced killer cells (CIK) assayed by MTT assay and FACS analysis. Chaetocin is a thiodioxopiperazine produced by fungi belonging to the chaetomiaceae family. In 2007, it was first reported that chaetocin shows potent and selective ex vivo anti-cancer activity by inducing reactive oxygen species. CIK cells are generated from CD3+/CD56- T lymphocytes with double negative CD4-/CD8- phenotype that are isolated from human blood. The addition of dist...
Source: GMS German Medical Science - May 4, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Prevalence of chronic diseases among older patients in German general practices.
CONCLUSIONS: Our study showed that the prevalence of CDs is high in the German elderly population. Hypertension was the most frequent chronic condition and around 25% of patients displayed at least four CDs. PMID: 26977142 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - March 17, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Gender-based differences in the antidepressant treatment of patients with depression in German psychiatric practices.
CONCLUSIONS: Gender did not impact therapy initiation in depressed patients. Further studies are needed to identify other potential factors involved. PMID: 26941590 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - March 5, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Recurrent urinary tract infections and complications after symptomatic versus antibiotic treatment: follow-up of a randomised controlled trial.
CONCLUSION: This follow-up analysis of a trial comparing antibiotic vs. symptomatic treatment for uncomplicated UTI showed that non-antibiotic treatment has no negative impact on recurrent UTI rates or pyelonephritis after day 28 and up to six months after initial treatment. Thus, a four week follow-up in UTI trials seems adequate. PMID: 26909012 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - February 28, 2016 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Quality expectations and tolerance limits of trial master files (TMF) - Developing a risk-based approach for quality assessments of TMFs.
This article addresses the question of when a trial master file (TMF) can be considered sufficiently accurate and complete: What attributes does the TMF need to have so that a clinical trial can be adequately reconstructed from documented data and procedures? Clinical trial sponsors face significant challenges in assembling the TMF, especially when dealing with large, international, multicenter studies; despite all newly introduced archiving techniques it is becoming more and more difficult to ensure that the TMF is complete. This is directly reflected in the number of inspection findings reported and published by the EMA ...
Source: GMS German Medical Science - December 25, 2015 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Navigating the maze of requirements for obtaining approval of non-interventional studies (NIS) in the European Union.
CONCLUSIONS: The process of obtaining approval for multicentre and multinational NIS is time consuming due to lack of transparency and the different regulatory requirements among member states. The EU pharmacovigilance legislation and clinical trial regulation No 536/2014 is a step forward in providing a regulatory framework for PASS (post-authorisation safety studies) and low intervention clinical trials, but since regulation No 536/2014 excludes NIS, it will be difficult to enforce harmonization of requirements for approval of NIS among member states. PMID: 26633964 [PubMed - in process] (Source: GMS German Medical Science)
Source: GMS German Medical Science - December 6, 2015 Category: Journals (General) Tags: Ger Med Sci Source Type: research

Autoimmune thyroiditis associated with neuromyelitis optica (NMO).
We report a case of a 50-year-old woman who was admitted initially with vomiting, hiccups and paraesthesias but was not diagnosed with NMO and presented with a severe progression of the disease. The patient was also diagnosed to have autoimmune thyroiditis with lymphocytic infiltration of the thyroid which progressed from hyperthyroidism to hypothyroidism. NMO diagnosis was established with seropositivity for NMO-IgG and MRI showing longitudinally extensive spinal cord lesions (3 or more spinal segments). In spite of treatment, the response was poor due to lack of early diagnosis and aggressive immunosuppressant therapy. ...
Source: GMS German Medical Science - December 6, 2015 Category: Journals (General) Tags: Ger Med Sci Source Type: research