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Relation of apixaban bleeding rates to dose in patients with chronic kidney disease
The objective of this study was to evaluate the safety and efficacy of apixaban 5 mg twice daily vs 2.5 mg twice daily for nonvalvular atrial fibrillation or venous thromboembolism in patients with chronic kidney disease stage 4 and 5, including those on hemodialysis. Data were collected retrospectively on patients with advanced chronic kidney disease and nonvalvular atrial fibrillation and/or venous thromboembolism who received apixaban while hospitalized at our institution between January 2013 and August 2018. The 5 mg twice daily group included 22 patients, and the 2.5 mg twice daily group included 73 patients. There wa...
Source: Baylor University Medical Center Proceedings - August 30, 2021 Category: Universities & Medical Training Authors: Sarah Yun Regan Sevinsky Tasleem Spracklin Alexandra Tatara Andrew Zoltan Fenves Source Type: research

Concomitant Use of NSAIDs or SSRIs with NOACs Requires Monitoring for Bleeding.
CONCLUSION: When NSAIDs or SSRIs are required for NOAC users with AF, physicians need to monitor bleeding events and consider the use of PPIs, especially for combined use of both drugs or when initiating NOACs treatment. PMID: 32882758 [PubMed - in process]
Source: Yonsei Medical Journal - August 31, 2020 Category: Universities & Medical Training Authors: Lee MT, Park KY, Kim MS, You SH, Kang YJ, Jung SY Tags: Yonsei Med J Source Type: research

Implication of Hemodynamic Assessment during Durable Left Ventricular Assist Device Support.
Abstract Durable left ventricular assist device therapy has improved survival in patients with advanced heart failure refractory to conventional medical therapy, although the readmission rates due to device-related comorbidities remain high. Left ventricular assist devices are designed to support a failing left ventricle through relief of congestion and improvement of cardiac output. However, many patients still have abnormal hemodynamics even though they may appear to be clinically stable. Furthermore, such abnormal hemodynamics are associated with an increased risk of future adverse events including recurrent he...
Source: Medicina (Kaunas) - August 14, 2020 Category: Universities & Medical Training Authors: Imamura T, Narang N Tags: Medicina (Kaunas) Source Type: research

Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography for Image Guidance in Percutaneous Patent Foramen Ovale Closure.
Conclusions: ICE-guided PFO device closure is quicker and less hazardous in terms of radiation exposure than the TEE-guided procedure, with similar procedural outcomes and duration of hospital stay. PMID: 32784843 [PubMed - in process]
Source: Medicina (Kaunas) - August 8, 2020 Category: Universities & Medical Training Authors: Moon J, Park Y, Park SJ, Oh PC, Jang AY, Chung WJ, Kang WC Tags: Medicina (Kaunas) Source Type: research

Determinants and Clinical Outcomes of Extended Dual Antiplatelet Therapy over 3 Years after Drug-Eluting Stent Implantation: A Retrospective Analysis.
CONCLUSION: In patients undergoing percutaneous coronary intervention, indefinite use of DAPT does not show superior outcomes to those of guideline-DAPT. Major bleeding rates are also similar. PMID: 32608203 [PubMed - in process]
Source: Yonsei Medical Journal - June 30, 2020 Category: Universities & Medical Training Authors: Lee OH, Kim BK, Hong SJ, Kim S, Ahn CM, Shin DH, Kim JS, Kang TS, Ko YG, Choi D, Hong MK, Jang Y Tags: Yonsei Med J Source Type: research

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