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Total 122 results found since Jan 2013.

The Transaortic Approach for Transcatheter Aortic Valve Replacement Initial Clinical Experience in the United States
ConclusionsTAVR via the TAO approach is technically feasible, seems to be associated with favorable outcomes, and expands the current alternative options for access sites in patients with inoperable aortic stenosis who are ineligible for TF TAVR.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 3, 2013 Category: Cardiology Source Type: research

The Transaortic Approach for Transcatheter Aortic Valve Replacement: Initial Clinical Experience in the United States
Conclusions: TAVR via the TAO approach is technically feasible, seems to be associated with favorable outcomes, and expands the current alternative options for access sites in patients with inoperable aortic stenosis who are ineligible for TF TAVR.
Source: Journal of the American College of Cardiology - April 12, 2013 Category: Cardiology Authors: Joel A. Lardizabal, Brian P. O'Neill, Harit V. Desai, Conrad J. Macon, Alexis P. Rodriguez, Claudia A. Martinez, Carlos E. Alfonso, Martin S. Bilsker, Roger G. Carillo, Mauricio G. Cohen, Alan W. Heldman, William W. O'Neill, Donald B. Williams Tags: Interventional Cardiology Source Type: research

Significance of the learning curve in left atrial appendage occlusion with two different devices
Conclusions: Complications associated with LAA occlusion cluster early in the periprocedural period and significantly decrease in frequency with operator experience. Initial experience gained with one of device may improve outcome with use of alternative LAA occlusion devices. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - October 6, 2013 Category: Cardiovascular & Thoracic Surgery Authors: I. Cruz‐Gonzalez, A Perez‐Rivera, R Lopez‐Jimenez, J Rodriguez‐Collado, J Martín‐Moreiras, M Cascon, A. Arribas, J.C. Gomez, Andrew O Maree, C Martin‐Luengo Tags: Original Studies Source Type: research

Are you bleeding? Validation of a machine-learning algorithm for determination of blood volume status: application to remote triage
In conclusion, a machine-learning algorithm developed from low-level physiological signals could reliably distinguish central hypovolemia from exercise, indicating that this device could provide battlefield remote triage capabilities.
Source: Journal of Applied Physiology - March 1, 2014 Category: Physiology Authors: Rickards, C. A., Vyas, N., Ryan, K. L., Ward, K. R., Andre, D., Hurst, G. M., Barrera, C. R., Convertino, V. A. Tags: ARTICLES Source Type: research

Learning More From the Dabigatran Concentrations in the RE-LY Study
We read with great interest the paper by Reilly et al. (1), which demonstrated that higher trough plasma dabigatran concentrations were associated with: 1) decreasing risk of stroke/systemic embolic event (SEE); and 2) increasing major bleeding risk in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial (2). The paper provides useful insights into the relationship between dabigatran exposure and clinical events but raises several questions.1.Time lag from blood samples to events.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 16, 2014 Category: Cardiology Source Type: research

Transition From Blinded Study Drug to Open-LabelTransition From Blinded Study Drug to Open-Label
Learn about an end-of-trial transition plan to minimize bleeding and stroke risks during a critical period. Journal of the American College of Cardiology
Source: Medscape Today Headlines - September 8, 2014 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Rare platelet G protein‐coupled receptor variants: What Can We Learn?
Summary Platelet expressed G protein‐coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side‐effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the molecular mechanisms that reg...
Source: British Journal of Pharmacology - September 18, 2014 Category: Drugs & Pharmacology Authors: S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: Review Article – 5th BPS Focused Meeting on Cell Signalling Themed Issue Source Type: research

Rare platelet GPCR variants: what can we learn?
Platelet‐expressed GPCRs are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side effects. In order to optimize the use of existing anti‐platelet drugs and to develop new therapies, more detailed knowledge is required relating to the molecular mechanisms that regulate GPCR and therefore platelet fu...
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: S P Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Anaesthetic management of transcatheter aortic valve implantation: results from the Italian CoreValve registry.
CONCLUSIONS: Our study indicates that, in experienced centres which have gone beyond their initial learning curve with TAVI, the use of local anaesthesia in a selected patient population can be associated with good clinical outcomes. Nevertheless, as severe procedural complications are possible, an anaesthesiologist should always be present as part of the team. PMID: 25772903 [PubMed - as supplied by publisher]
Source: EuroIntervention - March 20, 2015 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

What Are Common Inherited Thrombophilias?
Discussion Thrombophilia is the increased risk of thromboembolic disease due to a disorder. Thrombophilia can be inherited or acquired (such as antiphospholipid syndrome). The risk of thromboembolic events is much lower in children than adults. At-risk patients should avoid: Dehydration Sitting for prolonged time periods during travel Obesity Smoking Estrogen containing oral contraceptives Common inherited thrombophilias include: Prothrombin (Factor II mutation) Second most common Genetics: 1-2% prevalence is variable depending on location and ethnic background. Cause: Abnormal point mutation of the prothrombin gene t...
Source: PediatricEducation.org - May 25, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Is Aortic Valve Repair Reproducible? Analysis of the Learning Curve for Aortic Valve Repair
Conclusions Procedural safety and efficiency improves with experience whereas efficacy is consistent over time. AV repair is reproducible and appears to have a learning curve of approximately 40-60 cases. Teaser Aortic valve repair, while effective, is performed in a limited number of centres. We examined the learning curve in two centres with programs in AV repair for safety, efficiency, and efficacy endpoints. Early mortality was ≤1% in both cohorts. Frequency of safety endpoints was reduced in both cohorts. Procedural safety and efficiency improved with experience whereas efficacy was consistent over time. AV repair i...
Source: Canadian Journal of Cardiology - June 1, 2015 Category: Cardiology Source Type: research

Surgical treatment of complex aneurysms and thoracic aortic dissections with the Frozen Elephant Trunk technique
Conclusion: Frozen Elephant Trunk is a feasible technique and should be considered. The severity of the underlying disease justifies high mortality rates. The learning curve is a reality. This approach allows treatment of more than two segments at once. Nonetheless, if a second stage is made necessary, it is facilitated. Resumo Objetivo: Relatar experiência inicial com a técnica "Frozen Elephant Trunk". Métodos: Entre julho de 2009 e outubro de 2013, 21 pacientes, 66% homens, média de idade de 56±11 anos, 66,7% portadores de dissecção da aorta tipo A de Stanford (9,6% agudas e 57,1% crônicas), tipo B (14,3%, todas ...
Source: Revista Brasileira de Cirurgia Cardiovascular - June 19, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Mid-term study of transcatheter aortic valve implantation in an Asian population with severe aortic stenosis: two-year valve academic research consortium-2 outcomes.
CONCLUSION: Despite the unique clinical differences in an Asian population, this registry demonstrated favourable mid-term clinical and safety outcomes in Asians undergoing TAVI. PMID: 27516113 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - August 11, 2016 Category: Journals (General) Authors: Chew N, Hon JK, Yip WL, Chan SP, Poh KK, Kong WK, Teoh KL, Yeo TC, Tan HC, Tay EL Tags: Singapore Med J Source Type: research

A Woman's Place is at the Table
As I watched Donald Trump pace behind Hillary Clinton during the second presidential debate, I noticed myself growing increasingly uncomfortable. At the time, I attributed my discomfort to the generalized anxiety accompanying this particularly contentious election cycle. It was only when I saw the Saturday Night Live parody of that debate that I realized what had truly spooked me. It was the way Alec Baldwin, playing Donald Trump, lurked menacingly behind Kate McKinnon, playing Hillary Clinton, throughout the event. It was on his final swerve across the frame, to the soundtrack of Jaws, that I understood the source of my d...
Source: Healthy Living - The Huffington Post - November 2, 2016 Category: Consumer Health News Source Type: news

Mid-Term Follow-up of Minimally Invasive Multivessel Coronary Artery Bypass Grafting: Is the Early Learning Phase Detrimental?
Conclusions: Minimally invasive coronary artery bypass grafting can be safely initiated as a minimally invasive, multivessel alternative to open surgical coronary revascularization, with excellent mid-term results. Learning phase effects were not observed with regard to overall procedural safety, but rather in terms of improved freedom from conversion to sternotomy and from repeat revascularization.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - March 1, 2017 Category: Cardiovascular & Thoracic Surgery Tags: Original Articles Source Type: research