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Frequency, Reasons, and Impact of Premature Ticagrelor Discontinuation in Patients Undergoing Coronary Revascularization in Routine Clinical Practice: Results From the Bern Percutaneous Coronary Intervention Registry Coronary Artery Disease
Conclusions— Premature ticagrelor cessation in routine clinical practice occurred in 1 of 6 patients and was primarily related to adverse effects among which bleeding and dyspnea were the most frequent. Although premature ticagrelor cessation was not associated with adverse cardiovascular outcomes, this finding requires careful interpretation in view of the modest sample size. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT02241291.
Source: Circulation: Cardiovascular Interventions - May 10, 2018 Category: Cardiology Authors: Zanchin, T., Temperli, F., Karagiannis, A., Zanchin, C., Rasanen, M., Koskinas, K. C., Stortecky, S., Hunziker, L., Praz, F., Blochlinger, S., Moro, C., Moschovitis, A., Seiler, C., Billinger, M., Heg, D., Pilgrim, T., Valgimigli, M., Windecker, S., Raber Tags: Cardiovascular Disease, Secondary Prevention, Percutaneous Coronary Intervention Coronary Artery Disease Source Type: research

Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Prior Coronary Artery Bypass Grafting: Trends in Utilization and Propensity-Matched Analysis of In-Hospital Outcomes Structural Heart Disease
Conclusions— TAVR is being increasingly used as the preferred modality of AVR in patients with prior CABG. Compared with SAVR, TAVR is associated with similar in-hospital mortality but lower rates of in-hospital complications in this important subset of patients.
Source: Circulation: Cardiovascular Interventions - April 11, 2018 Category: Cardiology Authors: Gupta, T., Khera, S., Kolte, D., Goel, K., Kalra, A., Villablanca, P. A., Aronow, H. D., Abbott, J. D., Fonarow, G. C., Taub, C. C., Kleiman, N. S., Weisz, G., Inglessis, I., Elmariah, S., Rihal, C. S., Garcia, M. J., Bhatt, D. L. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Structural Heart Disease Source Type: research

Percutaneous Left Atrial Appendage Closure Is a Reasonable Option for Patients With Atrial Fibrillation at High Risk for Cerebrovascular Events New Techniques
Conclusions— This nationwide prospective registry shows that, in the French population, LAA closure is mainly used in patients with high comorbidity rates and a poor prognosis. LAA closure in such patients seems reasonable to decrease the stroke rate. The overall health status of these patients should be taken into account during the preprocedural evaluation process. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT02252861.
Source: Circulation: Cardiovascular Interventions - March 14, 2018 Category: Cardiology Authors: Teiger, E., Thambo, J.-B., Defaye, P., Hermida, J.-S., Abbey, S., Klug, D., Juliard, J.-M., Pasquie, J.-L., Rioufol, G., Lepillier, A., Elbaz, M., Horvilleur, J., Brenot, P., Pierre, B., Le Corvoisier, P., on behalf of the French National Left Atrial Appe Tags: Arrhythmias, Treatment, Ischemic Stroke New Techniques Source Type: research

Treatment of Aortic Stenosis With a Self-Expanding, Resheathable Transcatheter Valve: One-Year Results of the International Multicenter Portico Transcatheter Aortic Valve Implantation System Study Structural Heart Disease
Conclusions— The Portico TAVI system is safe and effective at 1 year, yielding low mortality and stroke rates in high-risk patients with severe AS. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01493284.
Source: Circulation: Cardiovascular Interventions - February 14, 2018 Category: Cardiology Authors: Linke, A., Holzhey, D., Mollmann, H., Manoharan, G., Schafer, U., Frerker, C., Worthley, S. G., van Boven, A. J., Redwood, S., Kovac, J., Butter, C., Sondergaard, L., Lauten, A., Schymik, G., Walther, T. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Structural Heart Disease Source Type: research

Impact of Clopidogrel Therapy on Mortality and Cancer in Patients With Cardiovascular and Cerebrovascular Disease: A Patient-Level Meta-Analysis Pharmacology
Conclusions— Across trials of cardiovascular and cerebrovascular disease, extended-duration clopidogrel on a background of aspirin has no overall effect on mortality or cancer but does reduce rates of myocardial infarction and stroke and increase rates of bleeding. These findings emphasize the need for selective use of extended clopidogrel therapy in patients in whom the risks of ischemia are not fully counterbalanced by the risks of bleeding.
Source: Circulation: Cardiovascular Interventions - January 8, 2018 Category: Cardiology Authors: Elmariah, S., Doros, G., Benavente, O. R., Bhatt, D. L., Connolly, S. J., Yusuf, S., Steinhubl, S. R., Liu, Y., Hsieh, W.-H., Yeh, R. W., Mauri, L. Tags: Pharmacology, Meta Analysis, Mortality/Survival Source Type: research

Percutaneous Left Atrial Appendage Closure: Current Devices and Clinical Outcomes Advances in Interventional Cardiology
Chronic oral anticoagulation therapy is the standard therapy for preventing thromboembolic events in patients with atrial fibrillation. However, oral anticoagulation has been associated with an increased risk of bleeding events, and despite the improvements linked to the introduction of direct oral anticoagulants, more than one third of atrial fibrillation patients still remain untreated. Over the past decade, percutaneous left atrial appendage closure has emerged as a valid alternative to anticoagulation therapy for the prevention of stroke/systemic embolism in patients with atrial fibrillation. In this article, we provid...
Source: Circulation: Cardiovascular Interventions - November 16, 2017 Category: Cardiology Authors: Asmarats, L., Rodes-Cabau, J. Tags: Atrial Fibrillation Advances in Interventional Cardiology Source Type: research

Culprit Vessel-Only Versus Multivessel Percutaneous Coronary Intervention in Patients With Cardiogenic Shock Complicating ST-Segment-Elevation Myocardial Infarction: A Collaborative Meta-Analysis Coronary Interventions
Conclusions— This meta-analysis of nonrandomized studies suggests that in patients with cardiogenic shock complicating ST-segment–elevation myocardial infarction, there may be no significant benefit with single-stage MV-PCI compared with CO-PCI. Given the limitations of observational data, randomized trials are needed to determine the role of MV-PCI in this setting.
Source: Circulation: Cardiovascular Interventions - November 16, 2017 Category: Cardiology Authors: Kolte, D., Sardar, P., Khera, S., Zeymer, U., Thiele, H., Hochadel, M., Radovanovic, D., Erne, P., Hambraeus, K., James, S., Claessen, B. E., Henriques, J. P. S., Mylotte, D., Garot, P., Aronow, W. S., Owan, T., Jain, D., Panza, J. A., Frishman, W. H., Fo Tags: Percutaneous Coronary Intervention, Revascularization, Meta Analysis, Acute Coronary Syndromes Coronary Interventions Source Type: research

Short-Term Outcome and Hemodynamic Performance of Next-Generation Self-Expanding Versus Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annulus: A Multicenter Propensity-Matched Comparison Structural Heart Disease
Conclusions— Albeit a similar safety profile with low clinical event rates, transcatheter aortic valve replacement with the ACURATE neo valve resulted in lower transvalvular gradients and consequently less prosthesis–patient mismatch compared with the SAPIEN 3 in patients with small annulus. These results emphasize the need of careful prosthesis selection in each individual patient.
Source: Circulation: Cardiovascular Interventions - September 26, 2017 Category: Cardiology Authors: Mauri, V., Kim, W. K., Abumayyaleh, M., Walther, T., Moellmann, H., Schaefer, U., Conradi, L., Hengstenberg, C., Hilker, M., Wahlers, T., Baldus, S., Rudolph, V., Madershahian, N., Rudolph, T. K. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Structural Heart Disease Source Type: research

Coronary Perforation Complicating Percutaneous Coronary Intervention in Patients With a History of Coronary Artery Bypass Surgery: An Analysis of 309 Perforation Cases From the British Cardiovascular Intervention Society Database Coronary Interventions
Conclusions— CP is an infrequent event during PCI-CABG but is closely associated with adverse clinical outcomes. A legacy effect of perforation on 12-month mortality was observed.
Source: Circulation: Cardiovascular Interventions - September 15, 2017 Category: Cardiology Authors: Kinnaird, T., Anderson, R., Ossei-Gerning, N., Cockburn, J., Sirker, A., Ludman, P., de Belder, M., Johnson, T. W., Copt, S., Zaman, A., Mamas, M. A., on behalf of the British Cardiovascular Intervention Society and the National Institute for Cardiovascul Tags: Percutaneous Coronary Intervention, Stent, Treatment Coronary Interventions Source Type: research

Optimized Screening of Coronary Artery Disease With Invasive Coronary Angiography and Ad Hoc Percutaneous Coronary Intervention During Transcatheter Aortic Valve Replacement Structural Heart Disease
Conclusions— In patients undergoing TAVR, screening of CAD with invasive coronary angiography and ad hoc PCI during TAVR is feasible and was not associated with increased periprocedural risks. PCI followed by TAVR in the same session had similar outcomes than TAVR in which PCI was not performed.
Source: Circulation: Cardiovascular Interventions - August 2, 2017 Category: Cardiology Authors: Barbanti, M., Todaro, D., Costa, G., Pilato, G., Picci, A., Gulino, S., Capranzano, P., La Spina, K., Di Simone, E., DArrigo, P., Deste, W., Indelicato, A., Cannata, S., Giannazzo, D., Imme, S., Tamburino, C., Patane, M., Buccheri, S., Capodanno, D., Sgro Tags: Diagnostic Testing, Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Structural Heart Disease Source Type: research

Dual Antiplatelet Therapy Continuation Beyond 1 Year After Drug-Eluting Stents: A Meta-Analysis of Randomized Trials Coronary Interventions
Conclusions— In this meta-analysis, extended DAPT beyond 1 year prevented myocardial infarctions and increased major bleedings, but the strength of evidence for these effects was not strong. DAPT continuation beyond 1 year showed no effects on mortality.
Source: Circulation: Cardiovascular Interventions - May 12, 2017 Category: Cardiology Authors: Ferrante, G., Condorelli, G., Pagnotta, P., Reimers, B. Tags: Percutaneous Coronary Intervention, Pharmacology, Stent, Thrombosis Coronary Interventions Source Type: research

Impact of Cerebrovascular Events Older Than One Year on Ischemic and Bleeding Outcomes With Cangrelor in Percutaneous Coronary Intervention Coronary Interventions
Conclusions— Among patients in the CHAMPION trials with a prior cerebrovascular event at least 1 year before the percutaneous coronary intervention, the efficacy and bleeding profile of cangrelor compared with clopidogrel was similar to that in the overall trial.
Source: Circulation: Cardiovascular Interventions - December 29, 2016 Category: Cardiology Authors: Sawlani, N. N., Harrington, R. A., Stone, G. W., Steg, P. G., Gibson, C. M., Hamm, C. W., Price, M. J., Prats, J., Deliargyris, E. N., Mahaffey, K. W., White, H. D., Bhatt, D. L. Tags: Percutaneous Coronary Intervention, Pharmacology, Ischemic Stroke, Transient Ischemic Attack (TIA) Coronary Interventions Source Type: research

Association Between Duration of Dual Antiplatelet Therapy and Angiographic Multivessel Disease on Outcomes in Patients Treated With Newer-Generation Drug-Eluting Stents Pharmacology
Conclusions— In patients treated with newer-generation drug-eluting stents, a significant interaction between DAPT strategy and multivessel disease was found regarding the occurrence of NACE at 1 year. Among adverse events, myocardial infarction was more frequent in 6-month DAPT than in 12-month DAPT in patients with multivessel disease.
Source: Circulation: Cardiovascular Interventions - October 31, 2016 Category: Cardiology Authors: Lee, S.-Y., Hong, M.-K., Shin, D.-H., Kim, J.-S., Kim, B.-K., Ko, Y.-G., Choi, D., Jang, Y., Kim, H.-S., Valgimigli, M., Colombo, A., Gilard, M., Palmerini, T., Stone, G. W. Tags: Percutaneous Coronary Intervention, Pharmacology, Stent Source Type: research

Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A North American Perspective--2016 Update Special Report
The optimal antithrombotic treatment regimen for patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation is an emerging clinical problem. Currently, there is limited evidenced-based data on the optimal antithrombotic treatment regimen, including antiplatelet and anticoagulant therapies, for these high-risk patients with practice guidelines, thus, providing limited recommendations. Over the past years, expert consensus documents have provided guidance to clinicians on how to manage patients with atrial fibrillation undergoing percutaneous coronary intervention. Given the recen...
Source: Circulation: Cardiovascular Interventions - October 31, 2016 Category: Cardiology Authors: Angiolillo, D. J., Goodman, S. G., Bhatt, D. L., Eikelboom, J. W., Price, M. J., Moliterno, D. J., Cannon, C. P., Tanguay, J.-F., Granger, C. B., Mauri, L., Holmes, D. R., Gibson, C. M., Faxon, D. P. Tags: Atrial Fibrillation, Anticoagulants, Pharmacology, Stent Special Report Source Type: research

Pharmacoinvasive Strategy Versus Primary Percutaneous Coronary Intervention in Patients With ST-Segment-Elevation Myocardial Infarction: A Propensity Score-Matched Analysis Myocardial Infarction
Conclusions— ST-segment–elevation myocardial infarction patients receiving pharmacoinvasive treatment, compared with PPCI, had shorter time to reperfusion, higher culprit-vessel patency, and similar 12-month clinical outcome.
Source: Circulation: Cardiovascular Interventions - August 30, 2016 Category: Cardiology Authors: Sim, D. S., Jeong, M. H., Ahn, Y., Kim, Y. J., Chae, S. C., Hong, T. J., Seong, I. W., Chae, J. K., Kim, C. J., Cho, M. C., Rha, S.-W., Bae, J. H., Seung, K. B., Park, S. J., on behalf of the Korea Acute Myocardial Infarction Registry (KAMIR) Investigator Tags: Myocardial Infarction, Catheter-Based Coronary and Valvular Interventions Source Type: research

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