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Source: Circulation: Cardiovascular Interventions
Condition: Bleeding

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Total 30 results found since Jan 2013.

Percutaneous Left Atrial Appendage Closure Is a Reasonable Option for Patients With Atrial Fibrillation at High Risk for Cerebrovascular Events New Techniques
Conclusions— This nationwide prospective registry shows that, in the French population, LAA closure is mainly used in patients with high comorbidity rates and a poor prognosis. LAA closure in such patients seems reasonable to decrease the stroke rate. The overall health status of these patients should be taken into account during the preprocedural evaluation process. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT02252861.
Source: Circulation: Cardiovascular Interventions - March 14, 2018 Category: Cardiology Authors: Teiger, E., Thambo, J.-B., Defaye, P., Hermida, J.-S., Abbey, S., Klug, D., Juliard, J.-M., Pasquie, J.-L., Rioufol, G., Lepillier, A., Elbaz, M., Horvilleur, J., Brenot, P., Pierre, B., Le Corvoisier, P., on behalf of the French National Left Atrial Appe Tags: Arrhythmias, Treatment, Ischemic Stroke New Techniques Source Type: research

Cerebrovascular Events After a Primary Percutaneous Coronary Intervention Strategy for Acute ST-Segment- Elevation Myocardial Infarction: Analysis From the HORIZONS-AMI Trial Coronary Interventions
Conclusions— In HORIZONS-AMI, cerebrovascular events within 3 years after ST-segment–elevation myocardial infarction in patients undergoing a primary percutaneous coronary intervention management strategy occurred in 2.0% of patients and were most frequent after coronary artery bypass grafting. Cerebrovascular events were often disabling and were strongly associated with high rates of death, reinfarction, recurrent ischemia, and major bleeding. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00433966.
Source: Circulation: Cardiovascular Interventions - April 9, 2015 Category: Cardiology Authors: Nikolsky, E., Mehran, R., Dangas, G. D., Xu, K., Parvataneni, R., Witzenbichler, B., Guagliumi, G., Kornowski, R., Genereux, P., Brener, S. J., Stone, G. W. Tags: Catheter-based coronary interventions: stents, Acute myocardial infarction, Acute Stroke Syndromes Source Type: research

Left Atrial Appendage and Closure: Who, When, and How Advances in Interventional Cardiology
Patients with nonvalvular atrial fibrillation have a 4- to 5-fold increase in strokes and that rhythm may be responsible for 15% to 20% of all strokes, particularly in the elderly. In this setting, thrombus in the left atrial appendage has been found to be the source of stroke in 90% of cases. Although oral anticoagulants have been found effective in reducing stroke rates, for a variety of issues, they may only be used in 40% to 50% of patients at increased risk for stroke. Given pathophysiology of stroke, site-specific therapy directed at left atrial appendage occlusion has been now studied for stroke prevention, and one ...
Source: Circulation: Cardiovascular Interventions - May 1, 2016 Category: Cardiology Authors: Holmes, D. R., Reddy, V. Y. Tags: Treatment Advances in Interventional Cardiology Source Type: research

Optimized Screening of Coronary Artery Disease With Invasive Coronary Angiography and Ad Hoc Percutaneous Coronary Intervention During Transcatheter Aortic Valve Replacement Structural Heart Disease
Conclusions— In patients undergoing TAVR, screening of CAD with invasive coronary angiography and ad hoc PCI during TAVR is feasible and was not associated with increased periprocedural risks. PCI followed by TAVR in the same session had similar outcomes than TAVR in which PCI was not performed.
Source: Circulation: Cardiovascular Interventions - August 2, 2017 Category: Cardiology Authors: Barbanti, M., Todaro, D., Costa, G., Pilato, G., Picci, A., Gulino, S., Capranzano, P., La Spina, K., Di Simone, E., DArrigo, P., Deste, W., Indelicato, A., Cannata, S., Giannazzo, D., Imme, S., Tamburino, C., Patane, M., Buccheri, S., Capodanno, D., Sgro Tags: Diagnostic Testing, Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Structural Heart Disease Source Type: research

Impact of Clopidogrel Therapy on Mortality and Cancer in Patients With Cardiovascular and Cerebrovascular Disease: A Patient-Level Meta-Analysis Pharmacology
Conclusions— Across trials of cardiovascular and cerebrovascular disease, extended-duration clopidogrel on a background of aspirin has no overall effect on mortality or cancer but does reduce rates of myocardial infarction and stroke and increase rates of bleeding. These findings emphasize the need for selective use of extended clopidogrel therapy in patients in whom the risks of ischemia are not fully counterbalanced by the risks of bleeding.
Source: Circulation: Cardiovascular Interventions - January 8, 2018 Category: Cardiology Authors: Elmariah, S., Doros, G., Benavente, O. R., Bhatt, D. L., Connolly, S. J., Yusuf, S., Steinhubl, S. R., Liu, Y., Hsieh, W.-H., Yeh, R. W., Mauri, L. Tags: Pharmacology, Meta Analysis, Mortality/Survival Source Type: research

Atrial Fibrillation and Aortic Stenosis: Impact on Clinical Outcomes Among Patients Undergoing Transcatheter Aortic Valve Implantation Structural Heart Disease
Conclusions— AF is common among high-risk patients with severe aortic stenosis undergoing transcatheter aortic valve implantation and is associated with a >2-fold increased risk of all-cause and cardiovascular mortality, irrespective of the type of AF. The gradient of risk directly correlates with the CHA2DS2–VASC score.
Source: Circulation: Cardiovascular Interventions - February 19, 2013 Category: Cardiology Authors: Stortecky, S., Buellesfeld, L., Wenaweser, P., Heg, D., Pilgrim, T., Khattab, A. A., Gloekler, S., Huber, C., Nietlispach, F., Meier, B., Juni, P., Windecker, S. Tags: Valvular heart disease, Catheter-based coronary and valvular interventions: other Structural Heart Disease Source Type: research

Hemorrhagic and Ischemic Outcomes After Bivalirudin Versus Unfractionated Heparin During Carotid Artery Stenting: A Propensity Score Analysis From the NCDR Peripheral Vascular Disease
Conclusions— Bivalirudin was associated with lower rates of hemorrhagic outcomes compared with UFH during the index hospitalization for carotid artery stenting. In-hospital and 30-day ischemic events were similar between the 2 groups. Randomized comparisons of these agents are needed to confirm these findings.
Source: Circulation: Cardiovascular Interventions - April 16, 2013 Category: Cardiology Authors: Wayangankar, S. A., Abu-Fadel, M. S., Aronow, H. D., Kennedy, K. F., Gupta, R., Yeh, R. W., Gray, W. A., Rosenfield, K., Hennebry, T. A. Tags: Heparin, Other anticoagulants, Carotid Stenosis, Angioplasty and Stenting, Transient Ischemic Attacks Peripheral Vascular Disease Source Type: research

Surgical Versus Percutaneous Coronary Revascularization for Multivessel Disease in Diabetic Patients With Non-ST-Segment-Elevation Acute Coronary Syndrome: Analysis From the Acute Catheterization and Early Intervention Triage Strategy Trial Coronary Artery Disease
Conclusions— In the large-scale ACUITY trial, diabetic patients with acute coronary syndrome and multivessel disease treated with PCI rather than CABG had less bleeding and acute kidney injury, greater need for repeat revascularization procedures, and comparable rates of myocardial infarction, stroke, and death through 1-year follow-up. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00093158.
Source: Circulation: Cardiovascular Interventions - May 27, 2015 Category: Cardiology Authors: Ben-Gal, Y., Mohr, R., Feit, F., Ohman, E. M., Kirtane, A., Xu, K., Mehran, R., Stone, G. W. Tags: Other diabetes, Catheter-based coronary interventions: stents, CV surgery: coronary artery disease Source Type: research

Culprit Vessel-Only Versus Multivessel Percutaneous Coronary Intervention in Patients With Cardiogenic Shock Complicating ST-Segment-Elevation Myocardial Infarction: A Collaborative Meta-Analysis Coronary Interventions
Conclusions— This meta-analysis of nonrandomized studies suggests that in patients with cardiogenic shock complicating ST-segment–elevation myocardial infarction, there may be no significant benefit with single-stage MV-PCI compared with CO-PCI. Given the limitations of observational data, randomized trials are needed to determine the role of MV-PCI in this setting.
Source: Circulation: Cardiovascular Interventions - November 16, 2017 Category: Cardiology Authors: Kolte, D., Sardar, P., Khera, S., Zeymer, U., Thiele, H., Hochadel, M., Radovanovic, D., Erne, P., Hambraeus, K., James, S., Claessen, B. E., Henriques, J. P. S., Mylotte, D., Garot, P., Aronow, W. S., Owan, T., Jain, D., Panza, J. A., Frishman, W. H., Fo Tags: Percutaneous Coronary Intervention, Revascularization, Meta Analysis, Acute Coronary Syndromes Coronary Interventions Source Type: research

Treatment of Aortic Stenosis With a Self-Expanding, Resheathable Transcatheter Valve: One-Year Results of the International Multicenter Portico Transcatheter Aortic Valve Implantation System Study Structural Heart Disease
Conclusions— The Portico TAVI system is safe and effective at 1 year, yielding low mortality and stroke rates in high-risk patients with severe AS. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01493284.
Source: Circulation: Cardiovascular Interventions - February 14, 2018 Category: Cardiology Authors: Linke, A., Holzhey, D., Mollmann, H., Manoharan, G., Schafer, U., Frerker, C., Worthley, S. G., van Boven, A. J., Redwood, S., Kovac, J., Butter, C., Sondergaard, L., Lauten, A., Schymik, G., Walther, T. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Structural Heart Disease Source Type: research

Triple Antithrombotic Therapy Is the Independent Predictor for the Occurrence of Major Bleeding Complications: Analysis of Percent Time in Therapeutic Range Pharmacology
Conclusions— Triple antithrombotic therapy predisposes patients to an increased risk of MBC regardless of the time in therapeutic range.
Source: Circulation: Cardiovascular Interventions - August 20, 2013 Category: Cardiology Authors: Naruse, Y., Sato, A., Hoshi, T., Takeyasu, N., Kakefuda, Y., Ishibashi, M., Misaki, M., Abe, D., Aonuma, K., Ibaraki Cardiovascular Assessment Study (ICAS) Registry Tags: Catheter-based coronary interventions: stents Pharmacology Source Type: research

Long-Term Results of Transapical Versus Transfemoral TAVI in a Real World Population of 1000 Patients With Severe Symptomatic Aortic Stenosis Structural Heart Disease
Conclusions— The data demonstrate that in an experienced multidisciplinary heart team, either access route can be performed with comparable results.
Source: Circulation: Cardiovascular Interventions - December 31, 2014 Category: Cardiology Authors: Schymik, G., Wurth, A., Bramlage, P., Herbinger, T., Heimeshoff, M., Pilz, L., Schymik, J. S., Wondraschek, R., Suselbeck, T., Gerhardus, J., Luik, A., Gonska, B.-D., Posival, H., Schmitt, C., Schrofel, H. Tags: CV surgery: valvular disease Structural Heart Disease Source Type: research

Moderate and Severe Preoperative Chronic Kidney Disease Worsen Clinical Outcomes After Transcatheter Aortic Valve Implantation: Meta-Analysis of 4992 Patients Structural Heart Disease
Conclusions— Both moderate and severe preoperative CKD significantly worsen transcatheter aortic valve implantation prognosis. Future studies on risk evaluation, prevention, and postoperative management are needed.
Source: Circulation: Cardiovascular Interventions - February 4, 2015 Category: Cardiology Authors: Gargiulo, G., Capodanno, D., Sannino, A., Perrino, C., Capranzano, P., Stabile, E., Trimarco, B., Tamburino, C., Esposito, G. Tags: Catheter-based coronary and valvular interventions: other Structural Heart Disease Source Type: research

Clinical Impact of Gastrointestinal Bleeding in Patients Undergoing Percutaneous Coronary Interventions Coronary Interventions
Conclusions— Among unselected patients undergoing PCI, GIB has a profound effect on prognosis. Triple antithrombotic therapy emerged as the single drug-related predictor of GIB in addition to patient-related risk factors within 1 year of PCI. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02241291.
Source: Circulation: Cardiovascular Interventions - April 24, 2015 Category: Cardiology Authors: Koskinas, K. C., Raber, L., Zanchin, T., Wenaweser, P., Stortecky, S., Moschovitis, A., Khattab, A. A., Pilgrim, T., Blochlinger, S., Moro, C., Juni, P., Meier, B., Heg, D., Windecker, S. Tags: Other anticoagulants, Platelet function inhibitors, Catheter-based coronary interventions: stents Source Type: research

Impact of Arterial Access Site on Outcomes After Primary Percutaneous Coronary Intervention: Prespecified Subgroup Analysis From the EUROMAX Trial Coronary Interventions
Conclusions— In this prespecified analysis from EUROMAX, radial access was preferred in lower risk patients and did not improve clinical outcomes. Bivalirudin was associated with less bleeding irrespective of access site. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01087723.
Source: Circulation: Cardiovascular Interventions - June 8, 2015 Category: Cardiology Authors: Hamon, M., Coste, P., van't Hof, A., Ten Berg, J., Clemmensen, P., Tabone, X., Benamer, H., Kristensen, S. D., Cavallini, C., Marzocchi, A., Hamm, C., Kanic, V., Bernstein, D., Anthopoulos, P., Deliargyris, E. N., Steg, P. G. Tags: Cardiovascular Pharmacology, Catheter-based coronary and valvular interventions: other, Acute myocardial infarction Coronary Interventions Source Type: research