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Comorbidities in patients with Obstructive Sleep Apnea syndrome (OSAS) in Reunion Island.
Conclusion: Morbid obesity, hypertension, diabetes, heart disease and respiratory illness are a predictor of severe OSAS in our patients especially snorers.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Omarjee, B., Budhan, S., Kichenin, C., Omarjee, A., Vellin, J. F. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

Air leak in Covid 19: experience from a DGH in the UK
Conclusions: Inpatient incidence of PTX and PM is still approximately 1%. Survival is better as overall Covid19 survival improves(direct mortality from air leak approx. 21 %) with mortality due to other factors rather than the air leak.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Aujayeb, A. Tags: 02.01 - Acute critical care Source Type: research

Impact of cardiovascular disease on in-hospital mortality in patients with COVID-19
Conclusion: COVID-19 patients with CVD comorbidites have a higher risk of in-hospital death. Optimal care and good control of CVD are essential in this patient group.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Pencheva Genova, V., Pancheva, R., Stoimenov, B., Manov, E., Kolev, V., Tsrancheva, R., Koshtikova, K., Stoianov, D., Donev, S. Tags: 01.01 - Clinical problems - no related to asthma or COPD Source Type: research

Local incidence and outcomes of patients with pneumothorax and pneumomediastinum in COVID-19
Conclusions: Inpatient incidence of PTX and PM is 0.98%. Survival is lower (54.5%) but difficult to compare in the presence of frailty and co-morbidities.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Jackson, K., Aujayeb, A., Aujayeb, A. Tags: Clinical problems Source Type: research

ICS withdrawal and rate of FEV1 decline in a primary care COPD population in England
Conclusion: In contrast to the WISDOM trial, mean rates of FEV1 decline were clinically similar between COPD patients on TT and COPD patients who withdrew from ICS.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Whittaker, H., Kiddle, S., Douglas, I., Wing, K., Quint, J. Tags: Epidemiology Source Type: research

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background. We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients identified using nationwide health registries. We estimated 0.08 (95% CI 0.06–0.11) heritability and identified five loci associated with OSA (p<5.0x10–8): rs4837016 near GAPVD1 (GTPase activating protein and VPS9 domains 1), rs1092856...
Source: European Respiratory Journal - May 6, 2021 Category: Respiratory Medicine Authors: Strausz, S., Ruotsalainen, S., Ollila, H. M., Karjalainen, J., Kiiskinen, T., Reeve, M., Kurki, M., Mars, N., Havulinna, A. S., Luonsi, E., Mansour Aly, D., Ahlqvist, E., Teder-Laving, M., Palta, P., Groop, L., Mägi, R., Mäkitie, A., Salom Tags: Sleep medicine Original Articles: Sleep medicine Source Type: research

Accelerated FEV1 decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients
Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We investigated the association between accelerated lung function decline and CVD outcomes and mortality in a primary care COPD population. COPD patients without a history of CVD were identified in the Clinical Practice Research Datalink (CPRD)-GOLD primary care dataset (n=36 382). Accelerated decline in forced expiratory volume in 1 s (FEV1) was defined using the fastest quartile of the COPD popula...
Source: European Respiratory Journal - March 4, 2021 Category: Respiratory Medicine Authors: Whittaker, H. R., Bloom, C., Morgan, A., Jarvis, D., Kiddle, S. J., Quint, J. K. Tags: COPD and smoking Original Articles: COPD Source Type: research

Late Breaking Abstract - In-hospital specialized weaning unit increase weaning success and increase ICU bed availability
Conclusion: In middle-income country, like Thailand, in-hospital specialized weaning unit improve weaning success rate and critical care bed utilization.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Limsukon, A., Liwsrisakun, C., Bumroongkit, C., Deesomchok, A., Theerakittikul, T., Tajarernmuang, P., Pothirat, C. Tags: Acute critical care Source Type: research

Montelukast and cardiovascular events: Insights from observational retrospective study
Conclusions: The results show a potential role of LTRAs, in particular montelukast, in targeting inflammation and reducing the ischemic events in asthmatic patients.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hoxha, M., Malaj, V., Quaglini, S., Capra, V., Evans, J. F., Sala, A., Rovati, G. E. Tags: Airway pharmacology and treatment Source Type: research

Forecasting the association of air quality and health outcomes in Ontario
Conclusions: Positive correlations between AQHI and health outcomes are found in this study which revealed that making the public aware of air pollution using AQHI may be helpful to reduce the impact of air pollution in people living with chronic diseases.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Liang, J., Ge, E., Zhu, J., Mcgihon, R., Terebessy, E., Su, Y., To, T. Tags: Occupational and environmental health Source Type: research

Asthma, asthma control and risk of stroke: the Nord-Trondelag Health Study (HUNT)
Conclusions: Active asthma was associated with modest increased risk of stroke in males and smokers independently of other conventional cardiovascular risk factors.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Cepelis, A., Brumpton, B., Laugsand, L., Langhammer, A., Janszky, I., Strand, L. Tags: Epidemiology Source Type: research

COPD as an additional risk factor for cardiovascular and respiratory events in patients with respiratory viral infection
Conclusion: There is no association between respiratory viral infection and COPD with the development of CVE or RE one year after positive virus PCR, regardless of previous CVRF. Both patients with CVRF without COPD and women with CVRF have more CVE.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Zambrano Chacon, M. D. L. A., Esteban-Lucia, L., Garcia Talavera, C. S., Nieto Roca, L., Venegas Rodriguez, A. M., Fernandez Roblas, R., Pello Lazaro, A. M., Acena Navarro, A., Villar Alvarez, F. Tags: Monitoring airway disease Source Type: research

Late Breaking Abstract - Inhaled corticosteroids (ICS), blood eosinophils (EOS), and FEV1 decline in patients with Chronic Obstructive Pulmonary Disease in a large UK primary healthcare setting
Conclusions: Regardless of blood EOS level, ICS-containing medication is associated with slower rates of FEV1 decline in COPD patients.Funding: GSK study 208602
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Whittaker, H., Mullerova, H., Jarvis, D., Barnes, N., Jones, P., Compton, C., Kiddle, S., Quint, J. Tags: Epidemiology Source Type: research

Impact of acute active and passive stress on physiological responses in adults with asthma
Conclusions: This study provides evidence that acute stress negatively influences the physiology of asthma patients. Active and passive stressors have differential impacts on respiratory and cardiovascular responses in adults with asthma. The active stress task seemed to be associated with increased metabolic work without affecting the caliber of bronchi and the passive task was associated with decreased CO2 production potentially suggesting hypocapnia.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bacon, S., Plourde, A., Paine, N., Cartier, A., Lavoie, K. Tags: Clinical Problems Source Type: research

A case control study:The role of leukotriene receptor antagonist in cardiovascular risk
Conclusions: The results do not show a reduction of the MI risk in patients using a LTRA; situation somehow different in IS patients from primary health care centers with a slightly protective effect of montelukast in reducing the IS risk, that, however, did not reach statistical significance. Future studies should require a larger sample size and monitor asthmatic patients from primary care.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Hoxha, M., Malaj, V., Rovati, G., Messler, M. V., Doce, C. R., Cavanillas, A. B. Tags: Airway Pharmacology and Treatment Source Type: research

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