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Stroke Incidence in Survivors of Carbon Monoxide Poisoning in South Korea: A Population-Based Longitudinal Study.
CONCLUSIONS CO poisoning is a high-risk factor for the development of stroke, evidenced by high incidences of stroke after CO poisoning. Practical strategies for preventing stroke after CO poisoning are needed, because stroke after CO poisoning affects adults of almost all ages, significantly increasing their socioeconomic burden. PMID: 33106468 [PubMed - in process]
Source: Medical Science Monitor - October 28, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model.
Authors: Peng YJ, Zhang X, Nanduri J, Prabhakar NR Abstract Sleep apnea with periodic cessation of breathing during sleep is a highly prevalent respiratory disorder affecting an estimated 10% of adults. Patients with sleep apnea exhibit several co-morbidities including hypertension, stroke, disrupted sleep, and neurocognitive and metabolic complications. Emerging evidence suggests that a hyperactive carotid body (CB) chemo reflex is an important driver of apneas in sleep apnea patients. Gasotransmitters carbon monoxide (CO) and hydrogen sulfide (H2S) play important roles in oxygen sensing by the CB. We tested the h...
Source: Advances in Experimental Medicine and Biology - October 27, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.
CONCLUSIONS These results indicated that the combined application of N-Butylphthalide and HBO could significantly improve the cognitive dysfunction of patients with DEACMP and have great clinical efficacy, which should be further studied. PMID: 28352069 [PubMed - in process]
Source: Medical Science Monitor - March 30, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Abstract Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concentration and activating some kinases, including PKG. The other mechanism of action involves induction of protein carbonylation. CO is known to directly and indirectly modulate the function of ion channels at the plasma membrane, which in turn have important repercussions in the cellular behavior. One gr...
Source: IUBMB Life - May 1, 2015 Category: Research Authors: Mauricio A. Retamal, Carmen G. León‐Paravic, Marcelo Ezquer, Fernando Ezquer, Rodrigo Del Rio, Amaury Pupo, Agustín D. Martínez, Carlos González Tags: Critical Review Source Type: research