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Specialty: Cytology
Condition: Alzheimer's
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Total 67 results found since Jan 2013.
Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Cell Research - August 2, 2023 Category: Cytology Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
The novel function of bexarotene for neurological diseases
Ageing Res Rev. 2023 Jul 24:102021. doi: 10.1016/j.arr.2023.102021. Online ahead of print.ABSTRACTBexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-cell lymphoma. However, it has also demonstrated promising therapeutic potential for neurological diseases such as stroke, traumatic brain injury, Parkinson's disease, and particularly Alzheimer's disease(AD). In AD, bexarotene inhibits the production and aggregation of amyloid β (Aβ), activates Liver X Receptor/RXR heterodimers to increase lipidated apolipoprotein E to remove Aβ, mitigates the negative impact of Aβ, regulates neuroinf...
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Yangtao Liu Pengwei Wang Guofang Jin Peijie Shi Yonghui Zhao Jiayi Guo Yaling Yin Qianhang Shao Peng Li Pengfei Yang Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Cell Research - July 26, 2023 Category: Cytology Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke
In this study, we identified a novel phenotype of macrophage-like B cells in brain-infiltrating immune cells expressing a high level of CD45. Macrophage-like B cells characterized by co-expression of B-cell and macrophage markers, showed stronger phagocytic and chemotactic functions compared with other B cells and showed upregulated expression of phagocytosis-related genes. Gene Ontology analysis found that the expression of genes associated with phagocytosis, including phagosome- and lysosome-related genes, was upregulated in macrophage-like B cells. The phagocytic activity of macrophage-like B cells was verified by immun...
Source: Cell Research - June 7, 2023 Category: Cytology Authors: Rui Wang Huaming Li Chenhan Ling Xiaotao Zhang Jianan Lu Weimin Luan Jianmin Zhang Ligen Shi Source Type: research
Tripartite Motif Protein Family in Central Nervous System Diseases
Cell Mol Neurobiol. 2023 Mar 29. doi: 10.1007/s10571-023-01337-5. Online ahead of print.ABSTRACTTripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is widely involved in various physiological and pathological processes, such as intracellular signal transduction, cell cycle regulation, oncogenesis, and innate immune response. Central nervous system (CNS) diseases are composed of encephalopathy and spinal cord diseases, which have a high disability and mortality rate. Patients are often unable to tak...
Source: Cellular and Molecular Neurobiology - March 29, 2023 Category: Cytology Authors: Mengtian Pan Xiang Li Guangchen Xu Xinjuan Tian Yunman Li Weirong Fang Source Type: research
The forkhead box O3 (FOXO3): a key player in the regulation of ischemia and reperfusion injury
This study is a comprehensive review of the expression of FOXO3 under ischemia and reperfusion (IR) and the molecular mechanisms of its regulation and function. We found that the expression level of FOXO3 under ischemia and IR is tissue-specific. Specifically, the expression level of FOXO3 is increased in the lung and intestinal epithelial cells after IR. However, FOXO3 is downregulated in the kidney after IR and in the skeletal muscles following ischemia. Interestingly, both increased and decreased FOXO3 expression have been reported in the brain, liver, and heart following IR. Nevertheless, these contribute to stimulatin...
Source: Cellular and Molecular Life Sciences : CMLS - March 20, 2023 Category: Cytology Authors: Moussa Omorou Yiwei Huang Meng Gao Chenxi Mu Weijing Xu Yuchun Han Hui Xu Source Type: research
Hydroxysafflor yellow A exerts neuroprotective effect by reducing A β toxicity through inhibiting endoplasmic reticulum stress in oxygen-glucose deprivation/reperfusion cell model
In this study, SH-SY5Y cell model treated with oxygen glucose deprivation/reperfusion (OGD/R) was used to explore the potential mechanism of HSYA. Results from CCK-8 showed that 10μM HSYA restored the cell viability after OGD 2 h/R 24 h. HSYA reduced the levels of malondialdehyde and ROS, while improved the levels of superoxide dismutase and glutathione peroxidase. Furthermore, apoptosis was inhibited and the expression of brain-derived neurotrophic factor was improved after HSYA treatment. In addition, the expression levels of amyloid-β peptides (Aβ) and BACE1 were decreased by HSYA, as well as the expression levels of...
Source: Cell Research - February 3, 2023 Category: Cytology Authors: Hui-Han Ma Jun-Ru Wen Hao Fang Shan Su Can Wan Chao Zhang Fang-Mei Lu Ling-Ling Fan Guang-Liang Wu Zi-Yi Zhou Lijun Qiao Shi-Jie Zhang Ye-Feng Cai Source Type: research
Neurotrophic factor-based pharmacological approaches in neurological disorders
Neural Regen Res. 2023 Jun;18(6):1220-1228. doi: 10.4103/1673-5374.358619.ABSTRACTAging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer's disease, Parkinson's disease, and ischemic stroke. The incidence of all these pathologies increases exponentially with age. Research on aging biology has currently focused on elucidating molecular mechanisms leading to the development of those pathologies. Cognitive deficit and neurodegeneration, common features of agin...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Margherita Alfonsetti Michele d'Angelo Vanessa Castelli Source Type: research
Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides
Neural Regen Res. 2023 Jun;18(6):1165-1178. doi: 10.4103/1673-5374.357903.ABSTRACTT cells are essential for a healthy life, performing continuously: immune surveillance, recognition, protection, activation, suppression, assistance, eradication, secretion, adhesion, migration, homing, communications, and additional tasks. This paper describes five aspects of normal beneficial T cells in the healthy or diseased brain. First, normal beneficial T cells are essential for normal healthy brain functions: cognition, spatial learning, memory, adult neurogenesis, and neuroprotection. T cells decrease secondary neuronal degeneration,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Mia Levite Source Type: research
β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
In this study, we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral artery. We found that β2M levels in the cerebral spinal fluid, serum, and brain tissue were significantly increased in the acute period but gradually decreased during the recovery period. RNA interference was used to inhibit β2M expression in the acute period of cerebral stroke. Tissue staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreased β2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao Source Type: research
Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models
Cell Mol Neurobiol. 2022 Aug 2. doi: 10.1007/s10571-022-01264-x. Online ahead of print.ABSTRACTStroke is a common cerebrovascular disease with high morbidity, mortality, and disability worldwide. Post-stroke dysfunction is related to the death of neurons and impairment of synaptic structure, which results from cerebral ischemic damage. Currently, transcranial magnetic stimulation (TMS) techniques are available to provide clinically effective interventions and quantitative diagnostic and prognostic biomarkers. The development of TMS has been 40 years and a range of repetitive TMS (rTMS) protocols are now available to regula...
Source: Cellular and Molecular Neurobiology - August 2, 2022 Category: Cytology Authors: Ying Xing Yuqian Zhang Congqin Li Lu Luo Yan Hua Jian Hu Yulong Bai Source Type: research
