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Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research

Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system
Ageing Res Rev. 2023 Jul 31;90:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the curre...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research

Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research

Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 6, 2022 Category: Surgery Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research

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