Query: stroke

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Total 5726 results found since Jan 2013.

Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors
ConclusionsDespite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
Source: Advances in Medical Sciences - July 11, 2018 Category: Biomedical Science Source Type: research

A review of 500 patients with acute stroke admitted to the University Hospital of Saudi Arabia. Similarities and differences compared with the published literature.
Authors: Zafar A Abstract Published studies have shown differences in types and underlying mechanisms of stroke between different regions of the world. There is a lack of published literature describing the characteristics of acute stroke in Saudi Arabia. The aim of this study was to identify different types and associated risk factors among acute stroke patients in Saudi Arabia. In this descriptive study, records of 500 patients with acute stroke were included. Acute stroke was classified as ischemic stroke, intracerebral hemorrhage, cerebral venous sinus thrombosis or subarachnoid hemorrhage. The TOAST classifica...
Source: Functional Neurology - July 11, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Endovascular management of extracranial occlusions at the hyperacute phase of stroke with tandem occlusions
ConclusionsCervical occlusion with coils and thrombectomy with stent-retrievers may be relevant to prevent early embolic recurrence in cervical occlusions with intraluminal thrombus. Stent-retrievers should be further assessed as a first-line approach, since delayed stroke may occur following occlusion with coils. Medical treatment alone may be sufficient when no cervical intraluminal thrombus is present, the Willis polygon is effective, and the cervical occlusion can be crossed easily to perform the intracranial thrombectomy.
Source: Journal of Neuroradiology - July 11, 2018 Category: Radiology Source Type: research

The importance of atrial fibrillation and selected echocardiographic parameters for the effectiveness and safety of thrombolytic therapy in patients with stroke
ConclusionsThe presence of atrial fibrillation worsens the patient's prognosis in terms of the functional status and survival during the acute period of stroke in patients treated with intravenous thrombolysis.Higher NIHSS and CHA2DS2VASc scores and reduced EF in patients with stroke treated with thrombolysis are the predictors of unfavorable short-term prognosis.
Source: Polish Journal of Neurology and Neurosurgery - July 10, 2018 Category: Neurosurgery Source Type: research

Noninfectious complications of acute stroke and their impact on hospital mortality in patients admitted to a stroke unit in Warsaw from 1995 to 2015
ConclusionsOver the last two decades Polish urban stroke units may have achieved a significant reduction of the occurrence of some noninfectious complications (i.e. MI, exacerbated CHF and DVT). However, the list of conditions associated with stroke unit mortality includes not only MI and exacerbated CHF but also PE, gastrointestinal bleeding and recurrent stroke.
Source: Polish Journal of Neurology and Neurosurgery - July 10, 2018 Category: Neurosurgery Source Type: research

Mobile Stroke Unit Reduces Time to Image Acquisition and Reporting INTERVENTIONAL
SUMMARY: Timely administration of thrombolytic therapy is critical to maximizing the likelihood of favorable outcomes in patients with acute ischemic stroke. Although emergency medical service activation overall improves the timeliness of acute stroke treatment, the time from emergency medical service dispatch to hospital arrival unavoidably decreases the timeliness of thrombolytic administration. Our mobile stroke unit, a new-generation ambulance with on-board CT scanning capability, reduces key imaging time metrics and facilitates in-the-field delivery of IV thrombolytic therapy.
Source: American Journal of Neuroradiology - July 9, 2018 Category: Radiology Authors: Nyberg, E. M., Cox, J. R., Kowalski, R. G., Vela-Duarte, D., Schimpf, B., Jones, W. J. Tags: INTERVENTIONAL Source Type: research

Noninfectious complications of acute stroke and their impact on hospital mortality in patients admitted to a stroke unit in Warsaw from 1995 to 2015
ConclusionsOver the last two decades Polish urban stroke units may have achieved a significant reduction of the occurrence of some noninfectious complications (i.e. MI, exacerbated CHF and DVT). However, the list of conditions associated with stroke unit mortality includes not only MI and exacerbated CHF but also PE, gastrointestinal bleeding and recurrent stroke.
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

The importance of atrial fibrillation and selected echocardiographic parameters for the effectiveness and safety of thrombolytic therapy in patients with stroke
ConclusionsThe presence of atrial fibrillation worsens the patient's prognosis in terms of the functional status and survival during the acute period of stroke in patients treated with intravenous thrombolysis.Higher NIHSS and CHA2DS2VASc scores and reduced EF in patients with stroke treated with thrombolysis are the predictors of unfavorable short-term prognosis.
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Neuroinflammatory responses in experimental and human stroke lesions
Neuroinflammation has been suggested as an attractive treatment target in stroke, since it offers a broader therapeutic window in comparison to currently established thrombolytic approaches. Inflammatory cells of both the innate and the adaptive immune system have been identified in experimental as well as human stroke lesions. In animal models, various therapeutic strategies targeting neuroinflammation have shown beneficial effects, however, translation to human disease has so far been disappointing.
Source: Journal of Neuroimmunology - July 6, 2018 Category: Allergy & Immunology Authors: Isabella Wimmer, Tobias Zrzavy, Hans Lassmann Tags: Review Source Type: research

Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors
ConclusionsDespite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
Source: Advances in Medical Sciences - July 6, 2018 Category: Biomedical Science Source Type: research

Endovascular management of extracranial occlusions at the hyperacute phase of stroke with tandem occlusions
ConclusionsCervical occlusion with coils and thrombectomy with stent-retrievers may be relevant to prevent early embolic recurrence in cervical occlusions with intraluminal thrombus. Stent-retrievers should be further assessed as a first-line approach, since delayed stroke may occur following occlusion with coils. Medical treatment alone may be sufficient when no cervical intraluminal thrombus is present, the Willis polygon is effective, and the cervical occlusion can be crossed easily to perform the intracranial thrombectomy.
Source: Journal of Neuroradiology - July 5, 2018 Category: Radiology Source Type: research

Successful recanalization using the Embolus Retriever with Interlinked Cage for acute stroke due to calcified cerebral emboli.
We describe a case of a mechanical thrombectomy with the Embolus Retriever with Interlinked Cage (ERIC) device in a patient with an acute ischemic stroke due to calcified cerebral emboli in the middle cerebral artery. The procedure was done after a failed recanalization attempt with manual aspiration thrombectomy. An 82-year-old woman presented to the emergency department with a sudden onset of right-sided weakness. A computed tomographic angiography showed left middle cerebral (M1 branch) calcified emboli. After the administration of an intravenous thrombolytic agent, the patient was transferred to the angiographic suite ...
Source: Interventional Neuroradiology - July 5, 2018 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
CONCLUSIONS: The present study demonstrates for the first time a graded relation between TMAO levels and the risk of subsequent cardiovascular events in patients with recent prior ischemic stroke. Our data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAO levels. PMID: 29976769 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 5, 2018 Category: Cardiology Authors: Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, Zhu W, Bavendiek U, Hazen SL, Endres M, Landmesser U Tags: Arterioscler Thromb Vasc Biol Source Type: research

The potential dangers of neck manipulation & risk for dissection and devastating stroke: An illustrative case & review of the literature.
The potential dangers of neck manipulation & risk for dissection and devastating stroke: An illustrative case & review of the literature. Biomed Res Rev. 2018;2(1): Authors: Turner RC, Lucke-Wold BP, Boo S, Rosen CL, Sedney CL Abstract Chiropractic cervical manipulation is a common practice utilized around the world. Most patients are never cleared medically for manipulation, which can be devastating for those few who are at increased risk for dissections. The high velocity thrust used in cervical manipulation can produce significant strain on carotid and vertebral vessels. Once a dissection h...
Source: Biomed Res - June 30, 2018 Category: Research Authors: Turner RC, Lucke-Wold BP, Boo S, Rosen CL, Sedney CL Tags: Biomed Res Rev Source Type: research

Pentraxin-3 in Thrombolytic Therapy for Acute Ischemic Stroke: No Relation with Curative Effect and Prognosis.
CONCLUSIONS PTX3 is not suitable to serve as an indicator of thrombolytic efficacy and had no association with long-term prognosis in stroke patients receiving thrombolytic therapy. PMID: 29949524 [PubMed - in process]
Source: Medical Science Monitor - June 29, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Fibrinolysis: Strategies to enhance the treatment of acute ischemic stroke.
This article is protected by copyright. All rights reserved. PMID: 29953716 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 28, 2018 Category: Hematology Authors: Henderson SJ, Weitz JI, Kim PY Tags: J Thromb Haemost Source Type: research

Letter by Singh et al Regarding Article, “Imaging Characteristics of Venous Parenchymal Abnormalities” Letter to the Editor
Source: Stroke - June 25, 2018 Category: Neurology Authors: Ravinder-Jeet Singh, Girish Baburao Kulkarni Tags: Cerebrovascular Disease/Stroke, Thrombosis Letters to the Editor Source Type: research

Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives Basic Sciences
Conclusions—The results indicate that detoxification of acrolein by NAC derivatives is caused through glutathione conjugation with acrolein catalyzed by glutathione S-transferases, which can be stabilized by NAC derivatives. This is a new concept of acrolein detoxification by NAC derivatives.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Takeshi Uemura, Kenta Watanabe, Kenta Ko, Kyohei Higashi, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Koichi Takao, Yoshiaki Sugita, Akihiko Sakamoto, Yusuke Terui, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi Tags: Animal Models of Human Disease, Ischemia, Oxidant Stress, Ischemic Stroke Original Contributions Source Type: research

Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage Brief Report
Background and Purpose—Intracerebral hemorrhage is a considerable source of morbidity and mortality. This 3-center study describes outcomes of pediatric intracerebral hemorrhage and identifies 2-year neurological outcome predictors.Methods—Children 29 days to 18 years of age presenting with intracerebral hemorrhage from March 2007 to May 2015 were enrolled prospectively. Exclusion criteria included trauma; intracranial tumor; hemorrhagic transformation of arterial ischemic stroke or cerebral sinovenous thrombosis; isolated subdural, epidural, or subarachnoid hemorrhage; and abnormal baseline neurological function. Intr...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Giulia S. Porcari, Lauren A. Beslow, Rebecca N. Ichord, Daniel J. Licht, Jonathan T. Kleinman, Lori C. Jordan Tags: Pediatrics, Prognosis, Mortality/Survival, Intracranial Hemorrhage Brief Reports Source Type: research

Effects of Stroke Unit Care in Acute Ischemic Stroke Patient Ineligible for Thrombolytic Treatment.
Conclusion: The stroke unit increases the survival rate among stroke patient compared with the general medical ward and have less complication. PMID: 29911837 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - June 21, 2018 Category: General Medicine Tags: J Med Assoc Thai Source Type: research

Depressive symptoms in stroke patients treated and non-treated with intravenous thrombolytic therapy: a 1-year follow-up study
Conclusions(1) Thrombolysed and non-thrombolysed stroke survivors had similar frequency of depressive symptoms although the thrombolysed patients had more severe neurological deficits in the acute phase. It can be assumed that if thrombolysis had not been used, depressive symptoms would have been more frequent. (2) Lack of the rt-PA treatment was associated with three-time greater odds of screening for PSD at 3  months post-stroke, after adjustment for other PSD correlates. (3) Therefore, thrombolytic therapy seems to have a positive, but indirect, effect on patients’ mood, especially in the first months after stroke. (...
Source: Journal of Neurology - June 18, 2018 Category: Neurology Source Type: research

Dietary Intake of Energy and Nutrients from Breakfast and Risk of Stroke in The Japanese Population: The Circulatory Risk in Communities Study (CIRCS).
CONCLUSIONS: A higher intake of energy from breakfast, primarily saturated or monounsaturated fat, was associated with a reduced risk of intracerebral hemorrhage in Japanese men. PMID: 29899172 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - June 16, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding.
CONCLUSIONS: The study identifies lymphopenia as a previously unrecognized risk factor for secondary hemorrhagic transformation in mice after severe ischemic stroke. T cells prevent hemorrhagic transformation by their capacity to bind platelets through P-selectin. The results highlight the role of T cells in bridging immunity and hemostasis in ischemic stroke. PMID: 29903733 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 14, 2018 Category: Cardiology Authors: Salas-Perdomo A, Miró-Mur F, Urra X, Justicia C, Gallizioli M, Zhao Y, Brait VH, Laredo C, Tudela R, Hidalgo A, Chamorro Á, Planas AM Tags: Arterioscler Thromb Vasc Biol Source Type: research

The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.
CONCLUSIONS In patients with acute ischemic stroke, mechanical cerebral artery thrombectomy resulted in a good clinical outcome in 47% of cases, with and without intravenous thrombolysis therapy. PMID: 29887594 [PubMed - in process]
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Multicentric Experience in Distal-to-Proximal Revascularization of Tandem Occlusion Stroke Related to Internal Carotid Artery Dissection INTERVENTIONAL
CONCLUSIONS: Endovascular treatment of internal carotid dissection–related tandem occlusion stroke using the distal-to-proximal recanalization strategy appears to be feasible, with low complication rates and considerable rates of successful recanalization.
Source: American Journal of Neuroradiology - June 13, 2018 Category: Radiology Authors: Marnat, G., Bühlmann, M., Eker, O. F., Gralla, J., Machi, P., Fischer, U., Riquelme, C., Arnold, M., Bonafe, A., Jung, S., Costalat, V., Mordasini, P. Tags: INTERVENTIONAL Source Type: research

Dl-3-n-Butylphthalide (NBP) :A Promising Therapeutic Agent for Ischemic Stroke.
Dl-3-n-Butylphthalide (NBP):A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets. 2018 Jun 12;: Authors: Wang S, Ma F, Huang LJ, Zhang Y, Peng YC, Xing CH, Feng YP, Wang XL, Peng Y Abstract Stroke is a leading cause of morbidity and mortality in both developed and developing countries all over the world. The only drug for ischemic stroke approved by FDA is recombinant tissue plasminogen activator (rtPA). However, only 2-5% stroke patients receive rtPAs treatment due to its strict therapeutic time window. As ischemic stroke is a complex disease involving in multiple mecha...
Source: CNS and Neurological Disorders Drug Targets - June 12, 2018 Category: Drugs & Pharmacology Authors: Wang S, Ma F, Huang LJ, Zhang Y, Peng YC, Xing CH, Feng YP, Wang XL, Peng Y Tags: CNS Neurol Disord Drug Targets Source Type: research

Factor VIII, Protein C and Cardiovascular Disease Risk: The REasons for Geographic and Racial Differences in Stroke Study (REGARDS).
CONCLUSION:  Higher FVIII was associated with both CHD and stroke risk and the risk potentiated by low PC for CHD. Findings demonstrate that risks for cardiovascular diseases conferred by adverse levels of haemostasis biomarkers may be augmented by levels of other biomarkers. PMID: 29890521 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 11, 2018 Category: Hematology Authors: Zakai NA, Judd SE, Kissela B, Howard G, Safford MM, Cushman M Tags: Thromb Haemost Source Type: research

Safety profile of an 8F femoral arteriotomy closure using the Angio-Seal device in thrombolysed acute stroke patients undergoing thrombectomy.
Conclusion Use of the Angio-Seal closure device for 8F femoral access is safe in acute stroke patients. Intravenous thrombolysis prior to endovascular thrombectomy does not significantly alter femoral access site complication rate if this approach is used. PMID: 29871562 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - June 8, 2018 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Mean Platelet Volume, C-Reactive Protein, and Prognosis in Patients with Acute Ischemic Stroke Following Intravenous Thrombolytic Treatment.
CONCLUSIONS MPV and CRP values were significantly associated with improvement in the NIH Stroke Scale and MRS scores in AIS when patients were treated with IV thrombolytic therapy within 4.5 hours of the onset of symptoms. PMID: 29869620 [PubMed - in process]
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Rivaroxaban in the cardiovascular world: a direct anticoagulant useful to prevent stroke, and venous and arterial thromboembolism.
Authors: Seoane L, Cortés M, Aris Cancela ME, Furmento J, Baranchuk A, Conde D Abstract INTRODUCTION: Until recently, vitamin K antagonists were the only drugs available for long-term anticoagulation. The use of these drugs is laborious due to their variable pharmacokinetics and pharmacodynamics. The advent of direct oral anticoagulants has produced a paradigm shift due to their low incidence of drug interactions, their stable plasma levels and their lack of monitoring. Rivaroxaban, a factor Xa inhibitor, has been tested in different clinical scenarios and has proved to be effective and safe, even increasing the s...
Source: Expert Review of Cardiovascular Therapy - June 6, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence.
Abstract Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges between vascular sub-endothelial collagen and platelets. The rationale for vWF as a potential target in stroke comes from four bodies of evidence. (1) Animal models which recapitulate the pathogenesis of stroke and validate the concept of targeting vWF for stroke prevention and the use of the...
Source: Thrombosis and Haemostasis - May 31, 2018 Category: Hematology Authors: Buchtele N, Schwameis M, Gilbert JC, Schörgenhofer C, Jilma B Tags: Thromb Haemost Source Type: research

A Change of Heart: Yield of Cardiac Imaging in Acute Stroke Workup
This case report describes a patient who experienced a recurrent ischemic stroke within 24 h. Dual-energy computed tomography (DECT) angiography on admission showed 2 intracardiac thrombi, 1 in the left ventricle and 1 in the left atrial appendage. Following the second ischemic event, repeated DECT angiography showed that the ventricular thrombus had considerably diminished, suggesting that the recurrent brain infarction was caused by cardioembolism. This case emphasizes (1) the potential benefit of cardiac evaluation through CT angiography in the acute stroke setting, and (2) the use of DECT angiography for the detection ...
Source: Case Reports in Neurology - May 30, 2018 Category: Neurology Source Type: research

Knowledge about Stroke in Belo Horizonte, Brazil: A Community-Based Study Using an Innovative Video Approach
Conclusion: Female sex and a family history of stroke increased the odds of recognizing the signs of stroke. Knowledge about the clinical manifestations, risk factors, and management of stroke was low in the studied population.Cerebrovasc Dis Extra 2018;8:60 –69
Source: Cerebrovascular Diseases Extra - May 30, 2018 Category: Neurology Source Type: research

Abbott ’s Amplatzer Stroke Reduction Data Is Strong at EuroPCR
Abbott Laboratories’ Amplatzer Amulet left atrial appendage (LAA) occlusion device has been shown at one year to reduce stroke by 57% as compared to the predicted stroke risk. The data also showed it was able to make this reduction without the need for lifetime blood thinners.  The Abbott Park IL-based company released the data at EuroPCR, the annual meeting of the European Association of Percutaneous Cardiovascular Interventions in Paris, and simultaneously published in EuroIntervention. More than 1,078 patients suffering from atrial fibrillation (Afib) were in the study with one-year-follow up. “The Amulet is a devi...
Source: MDDI - May 24, 2018 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Source Type: news

Dynamic Changes of CHA2DS2-VASc Score and the Risk of Ischaemic Stroke in Asian Patients with Atrial Fibrillation: A Nationwide Cohort Study.
CONCLUSION:  In AF patients, stroke risk as assessed by the CHA2DS2-VASc score is dynamic and changes over time. Rates of ischaemic stroke increased when patients accumulated risk factors, and were re-classified into higher CHA2DS2-VASc score categories. Stroke risk assessment is needed at every patient contact, as accumulation of risk factors with increasing CHA2DS2-VASc score translates to greater stroke risks over time. PMID: 29723875 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 3, 2018 Category: Hematology Authors: Yoon M, Yang PS, Jang E, Yu HT, Kim TH, Uhm JS, Kim JY, Pak HN, Lee MH, Lip GYH, Joung B Tags: Thromb Haemost Source Type: research

Antibodies against HDL Components in Ischaemic Stroke and Coronary Artery Disease.
In this study, we investigated whether antibodies against HDL components had additional value to conventional cardiovascular risk factors for the diagnosis of ischaemic stroke (IS) and coronary artery disease (CAD). Cross-sectional study was conducted on 53 patients with IS, 51 with CAD and 55 healthy controls, and in vitro studies to validate findings of the clinical study. We determined serum immunoglobulin G (IgG) antibodies against HDL (aHDL), apolipoproteins (aApoA-I, aApoA-II and aApoC-I) and paraoxonase-1 (aPON1) as well as PON1 activity (PON1a), total antioxidant capacity and biomarkers of endothelial activation (s...
Source: Thrombosis and Haemostasis - May 3, 2018 Category: Hematology Authors: Batuca JR, Amaral MC, Favas C, Justino GC, Papoila AL, Ames PRJ, Alves JD Tags: Thromb Haemost Source Type: research

Established and potential echocardiographic markers of embolism and their therapeutic implications in patients with ischemic stroke.
Abstract Cardiogenic strokes comprised 11% of all strokes and 25% of ischemic strokes. An accurate identification of the cause of stroke is necessary in order to prepare an adequate preventive strategy. In this review the confirmed and potential causes of embolic strokes are presented, which can be detected in echocardiography in the context of present treatment guidelines and gaps in evidence. There remains a need for further studies assessing the meaning of potential cardiac sources of embolism and establishment of rules for optimal medical prevention (antiplatelet therapy [APT] vs. oral anticoagulation [OAC]) a...
Source: Cardiology Journal - May 2, 2018 Category: Cardiology Authors: Gąsiorek PE, Banach M, Maciejewski M, Głąbiński A, Paduszyńska A, Rysz J, Bielecka-Dąbrowa A Tags: Cardiol J Source Type: research

An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke.
Conclusions: In conclusion, our analysis supports that EBT, regardless of format (e.g., ET or IAT), is superior to the best medical therapy alone (e.g., IVT) in terms of mRS score in patients with AIS. In addition, the safety of EBT is similar to IVT. PMID: 29707581 [PubMed - in process]
Source: Biomed Res - May 1, 2018 Category: Research Authors: Chen SY, Zhang XR, Chen J, Ge WQ, Wang WW, Wang XS, Xie CL Tags: Biomed Res Int Source Type: research

Recognizing cerebral venous thrombosis in adults
Abstract: Cerebral venous thrombosis is an underrecognized but serious thrombotic disorder that affects cerebral veins and sinuses. Clinical presentation varies based on extent and location of thrombosis within the cerebral venous system, and can include headache, focal neurologic deficits, focal or generalized seizures, stroke, and coma. Diagnosis is confirmed by brain and cerebral vascular imaging. Treatment focuses on anticoagulation, and outcomes are generally favorable.1,2
Source: Nursing Critical Care - May 1, 2018 Category: Nursing Tags: Feature: Stroke Spotlight Source Type: research

Tenecteplase: Thrombolytic of Choice in Stroke? Tenecteplase: Thrombolytic of Choice in Stroke?
The EXTEND-IA TNK trial suggesting better outcomes with tenecteplase than alteplase in the treatment of acute ischemic stroke has now been published in the New England Journal of Medicine.Medscape Medical News
Source: Medscape Critical Care Headlines - April 26, 2018 Category: Intensive Care Tags: Neurology & Neurosurgery News Source Type: news

Prevention and Management of Stroke in Obstetrics and Gynecology
The objective of this review is to provide an evidence-based summary of stroke incidence, risk factors, prevention, and treatment of stroke in pregnancy. The impact of postpartum contraceptive use can on stroke risk is summarized.
Source: Clinical Obstetrics and Gynecology - April 26, 2018 Category: OBGYN Tags: The Prevention and Management of Thrombosis in Obstetrics and Gynecology Source Type: research

tPA in Stroke: ' The Facts Are Clear ' tPA in Stroke: ' The Facts Are Clear '
Thrombolytic treatment for stroke remains controversial among specialties. Here, a neurologist argues for its use.Medscape Neurology
Source: Medscape Today Headlines - April 20, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Expert Column Source Type: news

Understanding delays in acute stroke care: a systematic review of reviews
ConclusionThis review provides a wide overview of factors influencing acute stroke pathway. Since it was observed that the identified factors were interrelated, they needed to be analyzed in a systematic way. We hence created a synthetic framework that combines several categories of factors while assuming that factor weight varies from a study context to another. Better knowledge on underlying mechanisms between factors would provide crucial improvement of the interventions aiming at reducing delays in both pre-hospital and inhospital stages. For future research, we recommend adopting a systemic perspective on factors infl...
Source: The European Journal of Public Health - April 20, 2018 Category: General Medicine Source Type: research

Is von Willebrand factor associated with stroke and death at mid-term in patients with non-valvular atrial fibrillation?
CONCLUSIONS: High vWF plasma concentrations may discriminate patients with NVAF at greater risk of stroke or all-cause death. PMID: 29685722 [PubMed - as supplied by publisher]
Source: Archives of Cardiovascular Diseases - April 20, 2018 Category: Cardiology Authors: Ancedy Y, Berthelot E, Lang S, Ederhy S, Boyer-Chatenet L, Di Angelantonio E, Soulat-Dufour L, Etienney A, Adavane-Scheublé S, Boccara F, Cohen A Tags: Arch Cardiovasc Dis Source Type: research

Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures: A Scientific Statement From the American Heart Association.
Abstract Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeuti...
Source: Circulation - April 19, 2018 Category: Cardiology Authors: Eskey CJ, Meyers PM, Nguyen TN, Ansari SA, Jayaraman M, McDougall CG, DeMarco JK, Gray WA, Hess DC, Higashida RT, Pandey DK, Peña C, Schumacher HC, American Heart Association Council on Cardiovascular Radiology and Intervention and Stroke Council Tags: Circulation Source Type: research

Varicella-Associated Stroke
A previously healthy, unimmunized 11-month-old boy presented with acute right-sided weakness. On the day of presentation, his mother noted that his right arm and leg seemed to be weak when she woke him from his usual afternoon nap. Evaluation at an urgent care center confirmed right-sided facial weakness, decreased strength and movement of his right upper and lower extremities, and a lack of right-sided support in a sitting position. Computed tomography of the head without contrast was normal. He was transferred to a regional care center where head magnetic resonance imaging and magnetic resonance angiography demonstrated ...
Source: The Journal of Pediatrics - April 19, 2018 Category: Pediatrics Authors: Surabhi B. Vora, Catherine Amlie-Lefond, Francisco A. Perez, Ann J. Melvin Tags: Insights and Images Source Type: research

The Case Against Thrombolytic Therapy in Stroke The Case Against Thrombolytic Therapy in Stroke
A New York Times article siding with neurologists in their debate with emergency medicine over the benefits of tPA in ischemic stroke prompted Dr Mandrola to take a closer look at the data.theheart.org on Medscape
Source: Medscape Today Headlines - April 13, 2018 Category: Consumer Health News Tags: Cardiology Expert Column Source Type: news

Reversal of dabigatran using idarucizumab: single center experience in four acute stroke patients
AbstractDabigatran is a direct thrombin inhibitor and a non-vitamin-K-antagonizing oral anticoagulant, approved for the prevention of stroke and systemic embolization in atrial fibrillation. Idarucizumab is a humanized monoclonal antibody that was recently approved for antagonizing the anticoagulant effects of dabigatran. Here, we report the use of idarucizumab in four acute stroke patients treated with dabigatran in order to enable intravenous thrombolysis in three patients and emergent trepanation in one patient with space occupying subdural hematoma. Since experience on the optimal management of acute stroke patients un...
Source: Journal of Thrombosis and Thrombolysis - April 9, 2018 Category: Hematology Source Type: research

Using light microscopy for diagnosing the cause of a case of acute stroke
A 60-year-old febrile man was transferred to the emergency department after being found alone and unconscious in a park. No medical history was available. Brain CT revealed a hyperdense lesion in the basilar artery (figure, A) suggesting a thromboembolic occlusion, which was subsequently thromboaspirated (figure, B and C). The fresh thrombus was retrieved (figure, D) and urgently analyzed using light microscopy, which revealed colonies of gram-positive bacilli (figure, E). A cardiac echogram showed severe mitral valve insufficiency and vegetations on its anterior leaflet (figure, F). After mitral valve repair and a long co...
Source: Neurology Clinical Practice - April 9, 2018 Category: Neurology Authors: Hajdu, S. D., Maillard, M., Antiochos, P., Saliou, G. Tags: Stroke in young adults, All Infections, Embolism Case Source Type: research