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Condition: Thrombosis
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Total 15499 results found since Jan 2013.
High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging
CONCLUSION: The superior PA signal of Se@PPy nanomaterials can identify the extent of atherosclerotic carotid lesions, demonstrating the feasibility of PA imaging technology in diagnosing carotid thrombosis lesion formation. This study demonstrates nanocomposites and PA techniques for imaging and diagnosing carotid thrombosis in vivo.PMID:37520300 | PMC:PMC10377622 | DOI:10.2147/IJN.S404743
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: Fengbing He Wenzhong Hou Yintao Lan Weijian Gao Mengyu Zhou Jinghang Li Shutong Liu Bin Yang Jian Zhang Source Type: research
D-dimer to fibrinogen ratio predicts early neurological deterioration in ischemic stroke with atrial fibrillation
The D-dimer to fibrinogen ratio (DFR) is a good indicator of clot-producing activity in thrombotic disease, but its clinical usefulness in stroke patients with nonvalvular atrial fibrillation (NVAF) has not been studied. We evaluated the association between the DFR and early neurological deterioration (END) in acute ischemic stroke (AIS) patients with NVAF.
Source: Thrombosis Research - July 31, 2023 Category: Hematology Authors: Ki-Woong Nam, Chi Kyung Kim, Sungwook Yu, Kyungmi Oh, Jong-Won Chung, Oh. Young Bang, Gyeong-Moon Kim, Jin-Man Jung, Tae-Jin Song, Yong-Jae Kim, Bum Joon Kim, Sung Hyuk Heo, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon- Tags: Full Length Article Source Type: research
The onset of cerebral infarction may be affected by differences in atmospheric pressure distribution patterns
ConclusionsCerebral embolism and cerebral thrombosis exhibited significant differences in APDPs on the day of onset. Dehydration particularly in the other high-pressure type or in the anticyclone belt type should be prevented. Further investigation should focus on the other meteorological factors.
Source: Frontiers in Neurology - July 31, 2023 Category: Neurology Source Type: research
E-093 Carotid webs and stroke: a comprehensive overview of clinical characteristics, risk factors, and treatment modalities
ConclusionThis is the largest systematic review of CWs to date. This study provides novel information not only about risk factors and common treatment modalities for CWs, but also the relationship between CWs and stroke. This data may aid physicians in diagnosis of CWs in younger patients who present with stroke-like symptoms and no cardiovascular risk factors. Furthermore, medical treatment alone may not be as effective as stenting or surgical options.Disclosures N. Gupta: None. V. Kasulla: None. A. Shahbandi: None. J. Gendreau: None. R. Singh: None. N. Brown: None. J. Catapano: None. V. Srinivasan: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gupta, N., Kasulla, V., Shahbandi, A., Gendreau, J., Singh, R., Brown, N., Catapano, J., Srinivasan, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-097 Acute ischemic stroke thrombus proteome is associated with time since last known well
ConclusionsThis study points, for the first time, to differences in the proteomic landscapes between thrombi from AIS patients that are related to time since symptom onset. Taken together, the present data support a view of the stroke thrombus as a living, dynamic microenvironment with increasing intracellular protein and RNA processing with increased tLKW. More work is required to further characterize early and late stroke thrombi, as a changing clot landscape may directly underlie responsiveness to treatment.Disclosures S. Akkipeddi: None. R. Rahmani: None. N. Ellens: None. G. Kohli: None. D. Schartz: None. S. Chittaranj...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Akkipeddi, S., Rahmani, R., Ellens, N., Kohli, G., Schartz, D., Chittaranjan, S., Bhalla, T., Mattingly, T., Morrell, C., Bender, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
Introduction
Dear SNIS 20th Annual Meeting Attendee,The editorial board of the Journal of NeuroInterventional Surgery (JNIS) is pleased to provide this supplement containing abstracts of the state-of-the-art neurointerventional research that will be presented at this year’s annual meeting.The abstracts in this supplement represent the best scientific work in the neurointerventional field. The JNIS editorial board hopes that these abstracts serve as a catalyst for further endovascular research and improvements in patient care. This year’s supplement features a variety of abstracts pertaining to contemporary issues. These inc...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Tags: Introduction Source Type: research
O-010 Tigertriever in the treatment of acute ischemic stroke in patients with underlying intracranial atherosclerotic disease
ConclusionTigertriever exerts a higher radial force that can be manually tailored to achieve better recanalization in patients with LVO due to ICAD.ReferenceGupta R, Saver JL, Levy E, et al. New class of radially adjustable stentrievers for acute ischemic stroke: primary results of the multicenter TIGER trial. Stroke. May 2021;52(5):1534-1544. doi:10.1161/strokeaha.121.034436Abstract O-010 Figure 1(A) A right Ml occlusion due to underlying ICAD (arrowhead). (B) The Tigertriever is deployed across the stenosis. The device ‘massages’ the thrombus and exerts an increased radial force in stenotic lesions due to ICA...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ojeda, D., Sanchez, S., Miller, J., Almajali, M., Koul, P., Noboa, L., Ghannam, M., Samaniego, E. Tags: SNIS 20th annual meeting oral abstracts Source Type: research
O-012 Relationship between clot composition and procedural results for ischemic stroke aspiration thrombectomy: subset analysis from the INSIGHT registry
ConclusionsClot removed during neuroendovascular procedures can differ in consistency and removability, leading to an increased focus on thrombus composition as a crucial variable for improving outcomes of ischemic stroke. In this study, good final revascularization (mTICI 2b-3 at the final angiogram) occurred after aspiration thrombectomy regardless of clot composition. Ongoing analysis of collected specimens is expected to provide valuable information regarding thrombus biology and etiology and to aid in diagnosis, prognosis, and drug development.Abstract O-012 Table 1Clot composition vs procedural results for ischemic s...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kellner, C., Dabney, A., Baltan, S., Sohrabji, F., Pennypacker, K., Nanda, A., Woodward, K., Rivet, D., Fraser, J. Tags: SNIS 20th annual meeting oral abstracts Source Type: research
O-016 Thrombus permeability is associated with distinct proteomic features and differential susceptibility to adamts13 thrombolysis
ConclusionThrombus permeability is associated with distinguishable proteomics features, including greater abundance of platelet-related proteins in highly permeable clots and monocyte/macrophages in less permeable clots. These findings also suggest that highly pervious thrombi may be differentially susceptible to ADAMTS13 augmented thrombolysis.Disclosures D. Schartz: None. S. Akkipeddi: None. N. Ellens: None. R. Rahmani: None. G. Kohli: None. R. Ismail: None. S. Chittaranjan: None. K. Welle: None. T. Bhalla: None. T. Mattingly: None. C. Morrell: None. M. Bender: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Schartz, D., Akkipeddi, S., Ellens, N., Rahmani, R., Kohli, G., Ismail, R., Chittaranjan, S., Welle, K., Bhalla, T., Mattingly, T., Morrell, C., Bender, M. Tags: SNIS 20th annual meeting oral abstracts Source Type: research
O-035 Endovascular treatment of cerebral venous thrombosis involving the deep venous system
ConclusionsAlthough deep venous involvement of CVT is uncommon, these patients are at risk of quickly becoming critically ill with an elevated rate of death or dependency. Although these patients may develop stroke, hemorrhage, or neurologic decline prompting consideration of endovascular therapy, the deep cerebral venous system is not easily accessible with catheters due to small lumens and risk of perforation. It has been proposed that deep cerebral veins may have a higher chance of recanalization if venous thrombus burden is reduced in other parts of the dural venous sinuses. Current literature has not fully explored th...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Morel, B., Hoffman, J., Folzenlogen, Z., Roark, C., Seinfeld, J., Case, D. Tags: SNIS 20th annual meeting oral abstracts Source Type: research
P-003 The zoomTMRDL radial access system for neurointervention: an early single-center experience
ConclusionsThe use of Zoom RDLTM Radial Access System is technically feasible and effective for complex neurointerventional procedures with low complication rates.Disclosures R. Morsi: None. S. Kothari: None. S. Thind: None. H. Desai: None. S. Polster: None. F. Goldenberg: None. E. Coleman: None. J. Brorson: None. S. Mendelson: None. A. Mansour: None. S. Prabhakaran: None. T. Kass-Hout: 2; C; Brainomix: Consultant, Cerenovus: Consultant, Imperative Care: Consultant, Medtronic Inc.: Consultant, Microvention: Consultant, Stryker Neurovascular: Consultant.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Morsi, R., Kothari, S., Thind, S., Desai, H., Polster, S., Goldenberg, F., Coleman, E., Brorson, J., Mendelson, S., Mansour, A., Prabhakaran, S., Kass-Hout, T. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research
E-006 U.S. health care system-wide transition from alteplase to tenecteplase before mechanical thrombectomy: functional outcomes, early reperfusion rates, intracranial bleeding and femoral access site complications
ConclusionsThe first-year experience demonstrates the effectiveness and safety of the transitioning from TPA to TNK. The higher early recanalization rates with TNK are striking. Additional studies are required to investigate whether TNK is superior to TPA in the setting of LVO stroke.Disclosures M. Collins: None. C. Schirmer: None. G. Weiner: None. O. Goren: None. I. Melamed: None. S. Dalal: None. M. Kole: None. A. Noto: None. P. Hendrix: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Collins, M., Schirmer, C., Weiner, G., Goren, O., Melamed, I., Dalal, S., Kole, M., Noto, A., Hendrix, P. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-027 Managing unruptured cerebral aneurysms detected during mechanical thrombectomy of acute ischemic stroke: considerations for treatment decisions
ConclusionAneurysm rupture during mechanical thrombectomy is associated with significant mortality and morbidity. Although rare, spontaneous aneurysm thrombosis is a potential mechanism of stroke and can carry an increased risk of aneurysmal rupture. Mechanisms of procedural rupture include stentriever or wire manipulation in an occult aneurysm and tractional forces in areas of aneurysm adhesion. Aspiration alone and the use of J shaped wires are technical considerations that can potentially decreased the possibility of aneurysm rupture in mechanical thrombectomy.Disclosures Y. Radaideh: None. K. Joshi: None. J. Gerzenshte...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Radaideh, Y., Joshi, K., Gerzenshtein, J., Chen, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-033 Optimization of endovascular treatment for patients with acute carotid plaque rupture and free- floating thrombus by use of two overlapping closed-cell stents with different radial force
ConclusionUse of the Carotid Wallstent as the first stent to secure the free-floating thrombus allows save delivery of the Xact stent which then adds a second closed-cell mesh layer as well as the needed radial force to expand the stent construct. This approach may decrease if not eliminate the need for post-stent angioplasty in the acute setting thus decreasing risk of thromboembolic complication.Disclosures A. Kuhn: None. J. Singh: None. S. Sarid: None. M. Garcia: None. A. Puri: 1; C; NIH, Microvention, Cerenovus, Medtronic Neurovascular and Stryker Neurovascular. 2; C; Medtronic Neurovascular, Stryker NeurovascularBalt,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Sarid, S., Garcia, M., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-049 Complications of middle meningeal artery embolization - a systematic review
ConclusionThe published literature suggests that MMA embolization is a generally well-tolerated procedure, but with a low risk of significant complications, including, but not limited to stroke, seizures, visual obscurations, and facial palsy. Further studies and sub-analyses are needed to fully characterize the incidence of such complications.Disclosures J. Gerstl: None. M. Shafi: None. S. Badikol: None. N. Nawabi: None. R. Mekary: None. M. Sukumaran: None. A. Kappel: None. A. Feroze: None. T. Smith: None. M. Aziz-Sultan: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gerstl, J., Shafi, M., Badikol, S., Nawabi, N., Mekary, R., Sukumaran, M., Kappel, A., Feroze, A., Smith, T., Aziz-Sultan, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
