Query: stroke

Filtered By:
Condition: Thrombosis

This page shows you your search results in order of date. This is page number 2.

Order by Relevance | Date

Total 5743 results found since Jan 2013.

Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm? EXTRACRANIAL VASCULAR
We report a series of 6 patients with COVID-19 with acute ischemic stroke due to intraluminal carotid artery thrombus presenting during an 8-day period. Six patients were included (5 men) with a mean age of 65.8 years (range, 55–78 years). COVID-19 was diagnosed by detection of Severe Acute Respiratory Syndrome coronavirus 2 in 5 patients and was presumed due to typical clinical and imaging findings in 1 patient. All patients had vascular risk factors including diabetes (83%), hyperlipidemia (100%), and smoking (17%). Four patients presented with large infarcts with initial NIHSS scores of 24–30. During their h...
Source: American Journal of Neuroradiology - September 9, 2020 Category: Radiology Authors: Mohamud, A. Y., Griffith, B., Rehman, M., Miller, D., Chebl, A., Patel, S. C., Howell, B., Kole, M., Marin, H. Tags: EXTRACRANIAL VASCULAR Source Type: research

Closure Device-Related Thrombosis After Anticoagulation With Dabigatran in Patients Undergoing Percutaneous Left Atrial Appendage Closure: Case Reports and Literature Review
We presented four rare cases of thrombosis formation on the occluder device. After the LAAC operation was successfully performed on patients, they followed a course of anticoagulation with dabigatran (110 mg b.i.d.), and device-related thrombosis (DRT) occurred as indicated by a transesophageal echocardiogram (TEE) during the follow-up period. Regressions were achieved after replacing dabigatran with rivaroxaban or warfarin for more than 1 month. No thrombosis or bleeding-related complications occurred in subsequent follow-ups.
Source: Frontiers in Pharmacology - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

A Novel Hybrid Membrane VAD as First Step Toward Hemocompatible Blood Propulsion.
P, Potapov E, Falk V, Mazza E Abstract Heart failure is a raising cause of mortality. Heart transplantation and ventricular assist device (VAD) support represent the only available lifelines for end stage disease. In the context of donor organ shortage, the future role of VAD as destination therapy is emerging. Yet, major drawbacks are connected to the long-term implantation of current devices. Poor VAD hemocompatibility exposes the patient to life-threatening events, including haemorrhagic syndromes and thrombosis. Here, we introduce a new concept of artificial support, the Hybrid Membrane VAD, as a first-of-its...
Source: Annals of Biomedical Engineering - September 8, 2020 Category: Biomedical Engineering Authors: Ferrari A, Giampietro C, Bachmann B, Bernardi L, Bezuidenhhout D, Ermanni P, Hopf R, Kitz S, Kress G, Loosli C, Marina V, Meboldt M, Pellegrini G, Poulikakos D, Rebholz M, Schmid Daners M, Schmidt T, Starck C, Stefopoulos G, Sündermann S, Thamsen B, Zill Tags: Ann Biomed Eng Source Type: research

Impact of different anticoagulation management strategies on outcomes in atrial fibrillation: Dutch and Belgian results from the GARFIELD-AF registry.
CONCLUSIONS: In GARFIELD-AF, despite similar characteristics, patients on anticoagulants were treated differently in NL and BE. Although the rate of major bleeding was 33% higher in NL, variations in bleeding, mortality and TE rates were not statistically significant. PMID: 32886853 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 4, 2020 Category: Hematology Authors: Seelig J, Hemels MEW, Xhaët O, Bongaerts MCM, de Wolf A, Groenemeijer BE, Heyse A, Hoogslag P, Voet J, Herrman JR, Vervoort G, Hermans W, Wollaert B, Boersma LVA, Hermans K, Lucassen A, Verstraete S, Adriaansen HJ, Mairesse GH, Terpstra WF, Faes D, Piete Tags: J Thromb Haemost Source Type: research

Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation
Publication date: Available online 2 September 2020Source: PhytomedicineAuthor(s): Tao-Fang Cheng, Jing Zhao, Qiu-Lin Wu, Hua-Wu Zeng, Yu-Ting Sun, Yu-Hao Zhang, Rui Mi, Xiao-Po Qi, Jing-Tao Zou, Ai-Jun Liu, Hui-Zi Jin, Wei-Dong Zhang
Source: Phytomedicine - September 2, 2020 Category: Drugs & Pharmacology Source Type: research

Cerebral Venous Thrombosis: A Comprehensive Review
Conclusion: CSVT is a potentially fatal neurological condition that is often under-diagnosed due to its nonspecific presentation. Timely diagnosis and treatment can reduce morbidity and mortality, remarkably improving the outcome in affected individuals.Eur Neurol
Source: European Neurology - September 2, 2020 Category: Neurology Source Type: research

Inhibition of PI3Kγ by AS605240 plus low-dose tissue plasminogen activator (tPA) combination improves thrombolytic therapy in a rat model of embolic stroke
Publication date: Available online 31 August 2020Source: Neuroscience LettersAuthor(s): Rong Jin, Wei Zhong, Shan Liu, Min Wang, Guohong Li
Source: Neuroscience Letters - September 2, 2020 Category: Neuroscience Source Type: research

Usefulness of Carotid Ultrasonography for Risk Stratification of Cerebral and Cardiovascular Disease.
Authors: Nezu T, Hosomi N Abstract Carotid ultrasonography is useful for the assessments of the risk stratification for stroke or coronary artery disease, because it is a simple, repeatable, and noninvasive procedure. The carotid intima-media thickness (IMT), which is assessed using carotid ultrasonography, is a widely used surrogate marker for the severity of atherosclerosis. Several large clinical studies showed that increased carotid IMT is associated with the future stroke or cardiovascular events. In addition, in many clinical trials, it has been adopted for surrogate markers of clinical endpoints of medical i...
Source: Journal of Atherosclerosis and Thrombosis - September 1, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Spontaneous echo contrast, left atrial appendage thrombus and stroke in patients undergoing transcatheter aortic valve implantation.
CONCLUSIONS: SEC and LAAT were detected in a relevant number of patients undergoing TAVI. SEC may represent an important risk factor for intraprocedural stroke and increased mortality was observed in patients with LAAT. PMID: 32863242 [PubMed - as supplied by publisher]
Source: EuroIntervention - August 31, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Selective inhibition of carboxypeptidase U may reduce microvascular thrombosis in rat experimental stroke.
CONCLUSIONS: A pronounced activation of the CPU system was observed during tMCAO in rats. Selective inhibition of CPU with AZD9684 was able to reduce fibrinogen deposition and brain edema, suggesting a reduction of MT but without a significant effect on final infarct volume. PMID: 32869423 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 31, 2020 Category: Hematology Authors: Mertens JC, Boisseau W, Leenaerts D, Di Meglio L, Loyau S, Lambeir AM, Ducroux C, Jandrot-Perrus M, Michel JB, Mazighi M, Hendriks D, Desilles JP Tags: J Thromb Haemost Source Type: research

Response to Comment on "Effect of Glycemic Index, Glycemic Load on Atherosclerotic Stenosis and Stroke".
Authors: Peng M, Li X, Liu Y, Zou M, Xia Y, Xu G PMID: 32848111 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 29, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effect of Glycemic Index and Glycemic Load on Atherosclerotic Stenosis and Stroke.
Authors: Yuan M, Zhou HY PMID: 32848110 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 29, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Correlation between left atrial spontaneous echocardiographic contrast and 5-year stroke/death in patients with non-valvular atrial fibrillation.
CONCLUSIONS: In this retrospective monocentric study, the presence of moderate/severe LASEC was an independent predictor of stroke/death at 5-year follow-up in patients with NVAF. The inclusion of LASEC in stroke risk scores could modestly improve risk stratification. PMID: 32873521 [PubMed - as supplied by publisher]
Source: Archives of Cardiovascular Diseases - August 29, 2020 Category: Cardiology Authors: Soulat-Dufour L, Lang S, Etienney A, Ederhy S, Ancedy Y, Adavane S, Chauvet-Droit M, Nhan P, Di Angelantonio E, Boccara F, Cohen A Tags: Arch Cardiovasc Dis Source Type: research

Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis
The coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 29, 2020 Category: Neurology Authors: Mai Yamakawa, Toshiki Kuno, Takahisa Mikami, Hisato Takagi, Gary Gronseth Source Type: research

The resolution of carotid arterial thrombus by oral anticoagulation after IV thrombolysis for chemotherapy-induced stroke: A case report
Rationale: Cancer-related stroke has been regarded as an emerging subtype of ischemic event. Acute treatment for this subtype may include the antiplatelet agents, anticoagulants, or endovascular intervention. Patient concerns: A 63-year-old woman with sudden-onset right hemiparesis and conscious change was sent to our emergency department. The patient had underlying sigmoid adenocarcinoma and received chemotherapy FOLFIRI (FOL, folinic acid; F, fluorouracil; and IRI, irinotecan) with targeted therapy cetuximab following lower anterior resection since the diagnosis was made. Diagnoses: Brain magnetic resonance angio...
Source: Medicine - August 28, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The 4S-AF Scheme (Stroke Risk; Symptoms; Severity of Burden; Substrate): A Novel Approach to In-Depth Characterization (Rather than Classification) of Atrial Fibrillation.
Abstract Atrial fibrillation (AF) is a complex condition requiring holistic management with multiple treatment decisions about optimal thromboprophylaxis, symptom control (and prevention of AF progression), and identification and management of concomitant cardiovascular risk factors and comorbidity. Sometimes the information needed for treatment decisions is incomplete, as available classifications of AF mostly address a single domain of AF (or patient)-related characteristics. The most widely used classification of AF based on AF episode duration and temporal patterns (that is, the classification to first-diagnos...
Source: Thrombosis and Haemostasis - August 24, 2020 Category: Hematology Authors: Potpara TS, Lip GYH, Blomstrom-Lundqvist C, Boriani G, Van Gelder IC, Heidbuchel H, Hindricks G, Camm AJ Tags: Thromb Haemost Source Type: research

Stress hyperglycemia is predictive of worse outcome in patients with acute ischemic stroke undergoing intravenous thrombolysis
In conclusion, we demonstrated that stress hyperglycemia, as measured by the GAR index, is associated to worse outcome in AIS patients undergoing IVT.
Source: Journal of Thrombosis and Thrombolysis - August 24, 2020 Category: Hematology Source Type: research

Acute Ischemic Stroke and COVID-19: Experience From a Comprehensive Stroke Center in Midwest US
Conclusion: AIS in the setting of COVID-19 is associated with worse outcomes, especially among African-American and Latino populations. Large vessel disease with ESUS was common suggesting an increased risk of coagulopathy and endothelial dysfunction as a potential etiology.
Source: Frontiers in Neurology - August 20, 2020 Category: Neurology Source Type: research

Atrial Fibrillation After Ischemic Stroke Detected by Chest Strap-Style 7-Day Holter Monitoring and the Risk Predictors: EDUCATE-ESUS.
CONCLUSIONS: In recent ESUS patients, the detection rate of AF using the 7-day Holter monitoring was 6.8% (95% CI 4.1%-11.1%). Brain natriuretic peptide, APC count, and APC short runs in the standard clinical workup seemed to be predictors of covert AF. PMID: 32801289 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 19, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Thrombolytic therapy in ischemic stroke patients with pre-stroke depression in the telestroke vs non-telestroke
This study aims to examine clinical risk factors associated with inclusion or exclusion for rtPA in acute ischemic stroke populations with pre-stroke depression in the telestroke versus a non-telestroke setting.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Robyn Moraney, Nicolas Poupore, Rachel Shugart, Mandy Tate, Ashley Snell, Katherine Brown, Thomas I. Nathaniel Source Type: research

Encephalopathy only stroke codes (EoSC) do not result in rt-PA treatments
Isolated mental status changes as a presenting sign (EoSC+), are not uncommon stroke code triggers. As stroke alerts, they still require the same intensive resources be applied. We previously showed that EoSC+ strokes (EoSC+ Stroke+) account for 0.1 –0.2% of all codes. Whether these result in thrombolytic treatment (rt-PA), and the characteristics/ risk factor profiles of EoSC+ Stroke+ patients, have not been reported.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Patrick M Chen, Dawn M Meyer, Brett C Meyer Source Type: research

Progressive thrombosis of cervical and intracranial arteries related to Ponatinib treatment for Chronic Myeloid Leukemia
Ponatinib is a third-generation Tyrosine Kinase Inhibitor (TKI), approved as first-line treatment for Chronic Myeloid Leukaemia (CML) chronic phase.Here we describe a CML patient with a history of subsequent TIAs and an ischemic stroke during Ponatinib treatment. Patient was admitted for a 3-day history of sudden onset left hemiparesis due to an acute ischemic stroke. MRI showed bilaterally the almost total absence of signal in the intracranial tract of anterior circulation and low signal of cerebral posterior circulation.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: E Spina, R Renna, LA Lanterna, ML Colleoni, V Andreone Tags: Case Report Source Type: research

An Autopsy Case of Lambl's Excrescences with Trousseau Syndrome that Caused Cardioembolic Stroke.
Authors: Hirayama T, Morioka H, Fujiwara H, Iwamoto K, Kiyozuka T, Takeo H, Ikeda K, Kano O Abstract The frequency and risk of embolism by Lambl's excrescences (LEs) remain unclear. We herein report an autopsy case of LEs that caused cardioembolic stroke. A 74-year-old man with colon cancer was hospitalized for ischemic stroke. His D-dimer levels were elevated. Thus, a diagnosis of ischemic stroke with Trousseau syndrome was made. At the autopsy, we found LEs in the aortic valves and thromboembolism of the brain blood vessels. This finding demonstrated that fibrin clots had adhered to the LEs because of coagulation...
Source: Internal Medicine - August 14, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Cholesterol Crystal in Thrombus Removed by Mechanical Thrombectomy Should be a Strong Marker for Aortogenic Embolic Stroke
Aortogenic embolic stroke (AES) is an important stroke mechanism. However, as many stroke patients have aortic atheromatous lesions, it is unclear whether these lesions are the cause of these strokes. Cholesterol crystals are the solid, crystalline form of cholesterol that is found in atherosclerosis, but not in cardiac diseases such as atrial fibrillation, valvular diseases, and cardiomyopathy. Therefore, if a cholesterol crystal is found in a thrombus removed by mechanical thrombectomy (MT), this makes it possible to diagnose a patient as having an atheromatous lesion.
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2020 Category: Neurology Authors: Noriko Matsumoto, Mizuho Takahashi, Takehiro Katano, Akihito Kutsuna, Takuya Kanamaru, Yuki Sakamoto, Kentaro Suzuki, Junya Aoki, Yasuhiro Nishiyama, Shinobu Kunugi, Akira Shimizu, Kazumi Kimura Tags: Case Report Source Type: research

Evaluation of the Effectiveness of Treatment with Botulinum Toxin on Sleep Quality in Stroke-Related Spasticity
Stroke is one of the most common causes of mortality and neurological disability worldwide.1 Spasticity is one of the most common findings of hemiplegia after stroke and the rate of spasticity after stroke is 40%.2 Spasticity is defined as sensory-motor control disorder, arising from intermittent or continuous involuntary activation of muscles resulting from upper motor neuron lesion.3 Although spasticity has benefits such as contributing to standing and walking, preventing osteoporosis, deep vein thrombosis and contributing to blood circulation, it is a complex disorder that causes serious disability in daily life activit...
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2020 Category: Neurology Authors: Hulya Deveci Source Type: research

Cerebral venous thrombosis in Argentina: clinical presentation, predisposing factors, outcomes and   literature review
Cerebral venous thrombosis (CVT) is an uncommon medical condition that primarily affects young individuals.  Previous studies suggest an annual incidence rate of 1-12/1,000,000 cases, representing 0.5% to 3% of all stroke.1-4 CVT is more common in childbearing women, usually associated with a transient prothrombotic state (e.g. pregnancy, puerperium, exposure to oral contraceptives).5
Source: Journal of Stroke and Cerebrovascular Diseases - August 12, 2020 Category: Neurology Authors: Mat ías Alet, Celina Ciardi, Alberto Alemán, Lucrecia Bandeo, Pablo Bonardo, Clarisa Cea, Juan Cirio, Jerónimo Cossio, María Cuculic, María Martha Esnaola, Fernando García-Pérez, Federico Giner, Maia Gómez-Schneider, Cristian Isaac, Sandra Lepera, Source Type: research

Venous Thromboembolism Research Priorities: A Scientific Statement From the American Heart Association and the International Society on Thrombosis and Haemostasis.
rsing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; and the International Society on Thrombosis and Haemostasis Abstract Venous thromboembolism is a major cause of morbidity and mortality. The impact of the US Surgeon General's The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism in 2008 has been lower than expected given the public health impact of this disease. This scientific statement highlights future research priorities in venous thromboembolism, developed by experts and a crowdsourcing survey across 16 scientific organizations. At the fundame...
Source: Circulation - August 11, 2020 Category: Cardiology Authors: Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS, American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke N Tags: Circulation Source Type: research

Computed tomography perfusion in patients of stroke with left ventricular assist device
AbstractLeft ventricular assist devices (LVAD) are widely applied for patients with severe heart failure as a bridge to heart transplantation as well as destination therapy. Patients with implanted LVAD have an increased risk of cerebral thrombosis and computed tomographic perfusion (CTP) has the potential to be performed for early diagnosis and treatment of acute ischemic stroke (AIS), including interventional thrombectomy. Here, we report our series of CTP examination in patients having suspected AIS after LVAD implantation. We retrospectively investigated 33 contrast-enhanced CTPs from January 2017 to December 2018 whic...
Source: Heart and Vessels - August 10, 2020 Category: Cardiology Source Type: research

Stroke: causes and clinical features
Stroke is a clinically defined syndrome of acute, focal neurological deficit attributed to vascular injury (infarction, haemorrhage) of the central nervous system. Stroke is the second leading cause of death and disability worldwide. Stroke is not a single disease but can be caused by a wide range of risk factors, disease processes and mechanisms. Hypertension is the most important modifiable risk factor for stroke, although its contribution differs for different subtypes. Most (85%) strokes are ischaemic, predominantly caused by small vessel arteriolosclerosis, cardioembolism and large artery athero-thromboembolism.
Source: Medicine - August 6, 2020 Category: Internal Medicine Authors: Stephen JX. Murphy, David J. Werring Tags: Acute neurology Source Type: research

Malignant Cerebral Ischemia in A COVID-19 Infected Patient: Case Review and Histopathological Findings
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is responsible for an unprecedented worldwide pandemic that has severely impacted the United States. As the pandemic continues, a growing body of evidence suggests that infected patients may develop significant coagulopathy with resultant thromboembolic complications including deep vein thrombosis, pulmonary embolism, myocardial infarction, and ischemic stroke. However, this data is limited and comes from recent small case series and observational studies on stroke types, mechanisms, and outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2020 Category: Neurology Authors: Smit D. Patel, Ryan Kollar, Patrick Troy, Xianyuan Song, Mohammad Khaled, Augusto Parra, Mubashir Pervez Source Type: research

Ischemic Stroke Caused by Carotid Stump at the Common Carotid Artery.
Authors: Hashimoto G, Wada S, Morita T, Tomohara S, Hara K, Kumabe M, Matsushima T, Kadowaki M, Hamaguchi M, Kuwashiro T, Yasaka M, Okada Y Abstract An 84-year-old man developed motor aphasia and right hemiparesis on postoperative day 1 after orchiectomy for suspected malignant lymphoma. He had a history of thoracic endovascular aortic repair for aortic aneurysm using a bypass graft from the right subclavian artery to the left common carotid artery (CCA); however, the graft had become occluded six months later. Brain magnetic resonance imaging revealed acute cerebral infarctions in the left frontal lobe. Carotid ul...
Source: Internal Medicine - August 1, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Free Fatty Acids in CSF and Neurological Clinical Scores: Prognostic Value for Stroke Severity in ICU.
Conclusion: FFA in CSF may serve as an independent prognostic biomarker for assessing the prognosis of acute ischemic stroke and the clinical outcome. It might be a useful biomarker for early detection of high-risk patients for poor outcome and hence more aggressive treatment. PMID: 32724675 [PubMed]
Source: Critical Care Research and Practice - July 31, 2020 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

The Value of ADAMTS13 in Predicting Clinical Outcomes in Patients With Acute Ischemic Stroke Receiving Thrombolysis
Conclusion: In our cohort, blood ADAMTS13 antigen level before rt-PA therapy could not be used as an independent biomarker in predicting clinical outcomes of AIS patients at 90 days.
Source: Frontiers in Neurology - July 31, 2020 Category: Neurology Source Type: research

Ischemic Stroke and Intracranial Hemorrhages During Impella Cardiac Support
Impella is a percutaneously placed, ventricular assist device for short-term cardiac support. We aimed to study acute neurologic complications during short-term cardiac support with Impella. We reviewed prospectively collected data of 79 consecutive persons implanted with Impella at a single tertiary center. Acute neurologic events (ANE) were defined as ischemic strokes or intracranial hemorrhages. Among those with ANE, specific causes of ischemic and hemorrhagic events were collected and discussed. Of 79 persons with Impella with median 8 days of support (range 1–33 days), six (7.5%) developed ANE at a median of 5 days ...
Source: ASAIO Journal - July 30, 2020 Category: Medical Devices Tags: Case Report Source Type: research

A Successful Quality Improvement Project for Detection and Management of Acute Stroke in Hospitalized Patients
CONCLUSION: The new IHS protocol has led to a marked increase in cases identified, rapid evaluation, and high utilization rate of acute stroke therapies.
Source: Journal of Neuroscience Nursing - July 30, 2020 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis.
Conclusion: Ischemic stroke might not be associated with portal vein thrombosis in liver cirrhosis. PMID: 32714987 [PubMed - in process]
Source: Biomed Res - July 29, 2020 Category: Research Authors: Zheng K, Guo X, Yi F, Wang L, Mancuso A, Qi X Tags: Biomed Res Int Source Type: research

Paradoxical Increase of Stroke in Patients with Defect of High Molecular Weight Multimers of the von Willebrand Factors following Transcatheter Aortic Valve Replacement.
CONCLUSION:  MLBCs and CT-ADP > 180 seconds were identified as predictors for ischemic stroke or TIA. The present study suggests that the defects of HMW multimers of the VWFs may contribute not only to bleeding events but also to thrombotic events. PMID: 32726854 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 29, 2020 Category: Hematology Authors: Matsushita K, Marchandot B, Trimaille A, Kibler M, Heger J, Peillex M, Hess S, Grunebaum L, Reydel A, Kindo M, Hoang MT, Sato C, De Poli F, Leddet P, Ohana M, Jesel L, Ohlmann P, Susen S, Morel O Tags: Thromb Haemost Source Type: research

Care for Patients with Stroke During the COVID-19 Pandemic: Physical Therapy and Rehabilitation Suggestions for Preventing Secondary Stroke
Infection with the novel severe acute respiratory syndrome coronavirus 2 causes the development of the novel 2019 coronavirus disease (COVID-19) and associated clinical symptoms, which typically presents as an upper respiratory syndrome such as pneumonia. Growing evidence indicates an increased prevalence of neurological involvement (e.g., in the form of stroke) during virus infection. COVID-19 has been suggested to be more than a lung infection because it affects the vasculature of the lungs and other organs and increases the risk of thrombosis.
Source: Journal of Stroke and Cerebrovascular Diseases - July 22, 2020 Category: Neurology Authors: Chien-Chih Wang, Jian-Kang Chao, Mong-Lien Wang, Yi-Ping Yang, Chien-Shiu Chien, Wei-Yi Lai, Yi-Chiang Yang, Yu-Hui Chang, Chen-Liang Chou, Chung-Lan Kao Source Type: research

Atrial Septal Aneurysm may Cause In-Hospital Recurrence of Cryptogenic Stroke.
CONCLUSIONS: The CHALLENGE ESUS/CS registry indicated that ASA was not rare in cryptogenic stroke, and ASA's clinical characteristics included higher age, reduced frequency of diabetes mellitus, and increased frequency of concomitant right-to-left shunt. ASA may be related to in-hospital stroke recurrence in cryptogenic stroke. PMID: 32684557 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - July 21, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Hemodynamics and Hemorrhagic Transformation After Endovascular Therapy for Ischemic Stroke
Hemorrhagic transformation remains a potentially catastrophic complication of reperfusion therapies for the treatment of large-vessel occlusion ischemic stroke. Observational studies have found an increased risk of hemorrhagic transformation in patients with elevated blood pressure as well as a high degree of blood pressure variability, suggesting a link between hemodynamics and hemorrhagic transformation. Current society-endorsed guidelines recommend maintaining blood pressure below a fixed threshold of 180/105 mmHg regardless of thrombolytic or endovascular intervention. However, given the high recanalization rates with ...
Source: Frontiers in Neurology - July 17, 2020 Category: Neurology Source Type: research

Apixaban for Stroke Prevention in Atrial Fibrillation: Why are Event Rates Higher in Clinical Practice than in Randomized Trials?-A Systematic Review.
CONCLUSION:  The higher risk profiles of patients in OSs versus RCTs, and higher rates of both bleeding and mortality not attributable to thromboembolism in patients treated with apixaban 2.5 versus 5 mg twice daily suggest that differences in patient characteristics are additional important contributors to the higher than expected thromboembolic event rates in clinical practice. PMID: 32668484 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 15, 2020 Category: Hematology Authors: de Vries TAC, Hirsh J, Xu K, Mallick I, Bhagirath VC, Eikelboom JW, Ginsberg JS, Kruger PC, Chan NC Tags: Thromb Haemost Source Type: research

Extracellular vesicles in atrial fibrillation and stroke
Atrial fibrillation (AF) is associated with a 5-fold increased risk of thromboembolic stroke. Extracellular vesicles (EVs) convey pathophysiological information and are possible biomarkers for risk of stroke.
Source: Thrombosis Research - July 15, 2020 Category: Hematology Authors: Åsa Thulin, Johan Lindbäck, Christopher B. Granger, Lars Wallentin, Lars Lind, Agneta Siegbahn Tags: Full Length Article Source Type: research

Efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke: a multicenter, randomized, double-blind, placebo-controlled trial
Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability and survival rates; however, to be effective, it must be given within 4.5  h of onset. Moreover, thromboly...
Source: BMC Neurology - July 14, 2020 Category: Neurology Authors: Jun Ni, Huisheng Chen, Guofang Chen, Yong Ji, Fei Yi, Zhuobo Zhang, Yi Yang, Jin Wu, Xueli Cai, Bei Shao, Jianfeng Wang, Yafang Liu, Deqin Geng, Xinhui Qu, Xiaohong Li, Yan Wei & hellip; Tags: Research article Source Type: research

Impact of the COVID-19 pandemic on hyperacute stroke treatment: experience from a comprehensive stroke centre in Singapore
AbstractThe Coronavirus disease 2019 (COVID-19) pandemic is rapidly evolving and affecting healthcare systems across the world. Singapore has escalated its alert level to Disease Outbreak Response System Condition (DORSCON) Orange, signifying severe disease with community spread. We aimed to study the overall volume of AIS cases and the delivery of hyperacute stroke services during DORSCON Orange. This was a single-centre, observational cohort study performed at a comprehensive stroke centre responsible for AIS cases in the western region of Singapore, as well as providing care for COVID-19 patients. All AIS patients revie...
Source: Journal of Thrombosis and Thrombolysis - July 13, 2020 Category: Hematology Source Type: research

COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature
We report the pooled incidence of AIS in COVID-19 patients to be 1.2%, with a high mortality rate. Elevatedd-dimer, fibrinogen and the presence of antiphospholipid antibodies appear to be prominent in COVID-19 patients with concomitant AIS, but further mechanistic studies are required to elucidate their role in pathogenesis.
Source: Journal of Thrombosis and Thrombolysis - July 13, 2020 Category: Hematology Source Type: research

Ponatinib-induced ischemic stroke in larval zebrafish for drug screening.
In this study, using Ponatinib as an inducer, we developed and characterized a zebrafish ischemic stroke model. This zebrafish ischemic stroke had the cerebral vascular endothelial injury, thrombosis, reduced blood flow, inflammation and apoptosis as well as the reduced motility. The zebrafish ischemic stroke model was validated with 6 known human therapeutic drugs of ischemic stroke (Aspirin, Clopidogrel, Naoxintong capsules, Edaravone, Xingnaojing injection, Shuxuening injection). The mRNA levels of the neovascularization-related gene (vegfaa) and vascular endothelial growth factor receptor gene (VEGFR), neurodevelopment...
Source: European Journal of Pharmacology - July 12, 2020 Category: Drugs & Pharmacology Authors: Zhu XY, Xia B, Ye T, Dai MZ, Yang H, Li CQ, Li P Tags: Eur J Pharmacol Source Type: research

Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke.
CONCLUSIONS: This study suggested a positive association between plasma TMAO and ischemic stroke. Further studies are required to explore the role of plasma TMAO concentrations in predicting stroke risk. PMID: 32641646 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - July 10, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

COVID-19 and Stroke: Casual or Causal Role?
We present a case of stroke in a 62-year-old COVID-19-positive patient, with multiple vascular risk factors. The patient arrived 1 h after onset of symptoms, was treated with recombinant tissue plasminogen activator (rtPA) with improvement of neurologic deficits, and later developed right foot arterial ischemia (recanalized by balloon catheter angioplasty) and left arm superficial venous thrombosis. A control computed tomography (CT) scan 7 days after onset showed hemorrhagic transformation of ischemic lesion without mass effect. However, respiratory and neurologic conditions improved so that the patient was discharged to ...
Source: Cerebrovascular Diseases - July 7, 2020 Category: Neurology Source Type: research

Management of Acute Ischemic Stroke-Specific Focus on Anesthetic Management for Mechanical Thrombectomy.
Abstract Acute ischemic stroke is a neurological emergency with a high likelihood of morbidity, mortality, and long-term disability. Modern stroke care involves multidisciplinary management by neurologists, radiologists, neurosurgeons, and anesthesiologists. Current American Heart Association/American Stroke Association (AHA/ASA) guidelines recommend thrombolytic therapy with intravenous (IV) alteplase within the first 3-4.5 hours of initial stroke symptoms and endovascular mechanical thrombectomy within the first 16-24 hours depending on specific inclusion criteria. The anesthesia and critical care provider may b...
Source: Anesthesia and Analgesia - July 7, 2020 Category: Anesthesiology Authors: Businger J, Fort AC, Vlisides PE, Cobas M, Akca O Tags: Anesth Analg Source Type: research

D1 receptor-mediated endogenous tPA upregulation contributes to blood-brain barrier injury after acute ischaemic stroke.
Abstract Blood-brain barrier (BBB) integrity injury within the thrombolytic time window is becoming a critical target to reduce haemorrhage transformation (HT). We have previously reported that BBB damage was initially damaged in non-infarcted striatum after acute ischaemia stroke. However, the underlying mechanism is not clear. Since acute ischaemic stroke could induce a significant increase of dopamine release in striatum, in current study, our aim is to investigate the role of dopamine receptor signal pathway in BBB integrity injury after acute ischaemia using rat middle cerebral artery occlusion model. Our dat...
Source: J Cell Mol Med - July 6, 2020 Category: Molecular Biology Authors: Wang Y, Wang X, Zhang X, Chen S, Sun Y, Liu W, Jin X, Zheng G Tags: J Cell Mol Med Source Type: research