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Role of bedside video-oculography in selecting neuroimaging in patients with acute vertigo and ataxia posterior fossa mass lesions
The acute vestibular syndrome ((AVS) is the sudden onset of continuous vertigo, nausea, vomiting and head motion intolerance [1]. The most common peripheral cause is a vestibular neuritis [2], and the most frequent central lesion associated with an AVS is an ischemic stroke in about 10 to 15% of cases [3 –5]; less frequently demyelinating plaques (multiple sclerosis (MS) and neuromyelitis optica (NMO)) [6], and inflammatory lesions associated with infectious and paraneoplastic disorders may be responsible.
Source: Journal of the Neurological Sciences - December 1, 2022 Category: Neurology Authors: Daniel Getz, Anusha Mangalampalli, Jeffrey Klopfenstein, Andrew Tsung, Jorge C. Kattah Source Type: research

Case report: Acute vestibular syndrome and cerebellitis in anti-Yo paraneoplastic syndrome
We report three patients evaluated over the past decade with an acute AVS along with subtle downbeat nystagmus (DBN), followed by dysarthria and progressive truncal and limb ataxia, as well as increasing DBN intensity.MethodsAll patients underwent neurologic examination, video-oculography, MRI, serum cancer markers, spinal fluid examination, paraneoplastic panel testing, and oncologic workup. With a consolidated diagnosis of cancer/paraneoplastic syndrome, we treated with plasma exchange (PLEX), high-dose steroids, surgery, and oncologic investigation. We additionally provided oncotherapy in one out of three patients.Resul...
Source: Frontiers in Neurology - August 26, 2022 Category: Neurology Source Type: research

Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature.
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of "definite PCD." We also carried out a systematic review of the literature in order to identify ...
Source: Cerebellum - August 28, 2019 Category: Neuroscience Authors: Vogrig A, Bernardini A, Gigli GL, Corazza E, Marini A, Segatti S, Fabris M, Honnorat J, Valente M Tags: Cerebellum Source Type: research

Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of “definite PCD.” We also carried out a systematic review of the literature in order to ident...
Source: The Cerebellum - August 28, 2019 Category: Neurology Source Type: research

Fatal Atypical Progressive Multifocal Leukoencephalopathy (PML) in an African American Female with Sarcoidosis Associated Lymphopenia (SAL). A Rare Case Report and Literature Review. (P2.317)
Conclusions:This is the first case of SAL presenting with medullary PML in an African-American patient not on immunosuppressive therapy. The role of SAL in PML pathogenesis or Sarcoidosis Associated Immunodeficiency is unclear. No guidelines for CD4/CD8 monitoring are available and needs further investigation. We suggest an aggressive diagnostic approach in evaluating Sarcoidosis with atypical neurologic manifestations and neuroimaging to reduce morbidity-mortality.Study Supported by: Not applicable.Disclosure: Dr. Rathore has nothing to disclose. Dr. Sweiss has nothing to disclose. Dr. Campanella has nothing to disclose. ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Rathore, J., Sweiss, N., Campanella, F., Andreoni, J., Wichter, M. Tags: HIV, HTLV-I, PML, Other Viral Infections, and CJD Source Type: research

Paraneoplastic Neurological Syndrome in Fallopian Tube Cancer.
We report on a rare case of paraneoplastic syndrome (PS) that was discovered on completion of diagnostic work-up to be an undifferentiated fallopian tube carcinoma. A 49-year-old Caucasian woman was admitted to neurology with vertigo, gait ataxia and dysarthria, transient ischaemic attack (TIA) and stroke were quickly excluded. Indicative for the further diagnosis of a paraneoplastic syndrome was the identification of onconeuronal antibodies the detection of which can be associated with certain tumour entities. The strongly positive anti-Yo antibody that is formed above all by breast and lung cancers as well as ovarian can...
Source: Geburtshilfe und Frauenheilkunde - December 12, 2015 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research