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Specialty: Allergy & Immunology
Cancer: Brain Cancers
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Total 35 results found since Jan 2013.
Microbiota, diet and the gut-brain axis in multiple sclerosis and acute stroke
This article is protected by copyright. All rights reserved.PMID:37470461 | DOI:10.1002/eji.202250229
Source: European Journal of Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Laura Diaz-Marugan Johan B Kantsj ö Andrina Rutsch Francesca Ronchi Source Type: research
Promoted Generation of T Helper 1-Like Regulatory T Cells After Transient Middle Cerebral Artery Occlusion in Type-2 Diabetic Mice
CONCLUSION: The generation of Th1-like Tregs was promoted in the brains of type 2 diabetic mice after stroke. Our study reveals significant Treg plasticity in diabetic stroke.Abbreviations: Foxp3: forkhead box P3; IFN-γ: interferon-γ; IL-10: interleukin-10; IL-12: interleukin-12; MCAO: middle cerebral artery occlusion; PBS: phosphate-buffered saline; STAT1: Signal transducer and activator of transcription 1; STAT5: Signal transducer and activator of transcription 1; T-bet: T-box expressed in T cells; TGF-β: transforming growth factor-β; Th1: T helper 1; TNF-α: tumor necrosis factor-α; Tregs: regulatory T cells. Foxp3...
Source: Immunological Investigations - April 19, 2023 Category: Allergy & Immunology Authors: Lei Jian Yanqi Hu Mingjie Gao Long Shu Source Type: research
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR- γ pathway after ischemic stroke
Cell Immunol. 2023 Mar 5;386:104704. doi: 10.1016/j.cellimm.2023.104704. Online ahead of print.ABSTRACTExploring regimens to facilitate microglia transformation from M1 to M2 phenotype is a feasible strategy to suppress neuroinflammation, therefore reinforcing functional recovery after ischemic stroke. Muscone easily crosses the blood brain barrier (BBB) and distributes throughout the brain. Here, the results illustrated the administration of 8 mg/kg muscone promoted functional recovery through reducing the infarct volume by 2,3,5-triphenyltetrazolium chloride (TTC) staining after ischemic stroke in mice. Then, the express...
Source: Cellular Immunology - March 15, 2023 Category: Allergy & Immunology Authors: Fei Liu Liwei Cao Shejing Hu Hongxiang Ye Qiang Wu Le Wu Source Type: research
