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Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

The technique of superselective ophthalmic artery chemotherapy for retinoblastoma: The Garrahan Hospital experience.
Conclusion SOAC is a safe technique with a very low complication rate. PMID: 29119878 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - November 10, 2017 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India
Conclusions: IAC is an effective therapy for globe preservation in eyes with intraocular RB, in the setting of a developing country like India. Larger studies with longer follow-up are required to validate these results.
Source: Indian Journal of Ophthalmology - May 17, 2017 Category: Opthalmology Authors: Pukhraj Rishi Tarun Sharma Minal Sharma Aditya Maitray Abhinav Dhami Vishvesh Aggarwal Saravanan Munusamy R Ravikumar Satheesh Ramamurthy Source Type: research

Retinoblastoma Control With Primary Intra-arterial Chemotherapy: Outcomes Before and During the Intravitreal Chemotherapy Era
Conclusions:The current era of retinoblastoma management using intra-arterial chemotherapy plus additional intravitreal chemotherapy (as needed for vitreous seeding) has improved globe salvage in eyes with advanced retinoblastoma.[J Pediatr Ophthalmol Strabismus. 2016;53(5):275 –284.]
Source: Journal of Pediatric Ophthalmology and Strabismus - September 20, 2016 Category: Opthalmology Source Type: research

Cerebral Vasoconstriction Triggered By Sympathomimetic Drugs During Intra-atrerial Chemotherapy
In this report, we highlight the potential risk of reversible cerebral vasoconstriction in children administered vasoactive drugs and discuss its relevance during treatment of retinoblastoma by intraarterial chemotherapy.
Source: Pediatric Neurology - January 21, 2013 Category: Neurology Authors: Todd Abruzzo, Mario Patino, James Leach, Ralph Rahme, James Geller Tags: Case Reports Source Type: research