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Drug: Insulin
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Total 393 results found since Jan 2013.
Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Comprehensive Physiology - June 26, 2023 Category: Physiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis
Hum Reprod Update. 2023 Jun 23:dmad015. doi: 10.1093/humupd/dmad015. Online ahead of print.ABSTRACTBACKGROUND: Current knowledge about the consequences of PCOS during the late reproductive years and after menopause is limited.OBJECTIVE AND RATIONALE: We performed a systematic review and meta-analysis of data on the pathophysiology, clinical manifestations, diagnosis, prognosis, and treatment of women ≥45 years of age-peri- or postmenopausal-with PCOS.SEARCH METHODS: Studies published up to 15 April 2023, identified by Entrez-PubMed, EMBASE, and Scopus online facilities, were considered. We included cross-sectional or pro...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Mercedes Mill án-de-Meer Manuel Luque-Ram írez L ía Nattero-Chávez H éctor F Escobar-Morreale Source Type: research
Applying a nutrition security lens to the Dietary Guidelines for Americans to address metabolic health
Front Nutr. 2023 Apr 21;10:1141859. doi: 10.3389/fnut.2023.1141859. eCollection 2023.ABSTRACTNutrition security - access to food that promotes well-being and prevents or treats disease, particularly among racial and ethnic minority populations, lower income populations, and rural and remote populations - is a national priority. Leading causes of death and disability in America, such as heart disease, stroke, cancer, and diabetes that disproportionately affect minorities are linked to preventable diet-related risk factors. Mounting evidence indicates that adherence to a lower-carbohydrate dietary pattern is associated with ...
Source: Rural Remote Health - May 8, 2023 Category: Rural Health Authors: Jeff S Volek Jonathan Clinthorne William S Yancy Source Type: research
