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Fatal Adverse Events of Dabigatran Combined With Aspirin in Elderly Patients: An Analysis Using Data From VigiBase
Conclusion: The fatal adverse events associated with the combined use of dabigatran and aspirin in elderly patients were mainly serious bleeding events, which often occurred within 1 month. Most of these cases had medication errors and most of the patients had multiple diseases, medications, or other conditions at the same time that increase the risk of bleeding. It is suggested that prescription of dabigatran and aspirin in elderly patients should go along with alertness for medication errors, care for correct dose or control of other bleeding risk factors, and the combined medication time should be as short as possible ...
Source: Frontiers in Pharmacology - December 22, 2021 Category: Drugs & Pharmacology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Risk of aspirin-related bleeding is higher in the over-75s
Conclusion This valuable cohort study helps to quantify the extent of bleeding risk in people taking aspirin for secondary prevention of cardiovascular disease. Aspirin is well known to carry bleeding risk – particularly in older adults – but this study suggests the risk may be higher than previously thought. The researchers say that for adults under the age of 75, the annual bleeding risk at around 1% is similar to that suggested by previous trials, as is the ratio of bleeds to the number of cardiovascular events. However, this risk increases for older adults, especially for major bleeds of the stomach and upper diges...
Source: NHS News Feed - June 14, 2017 Category: Consumer Health News Tags: Medication Older people Source Type: news

Low-gluten diet linked to heart attack risk
Conclusion This study has found that while overall gluten consumption in people without coeliac disease may not be related to heart disease risk, avoiding whole grains (wheat, barley and rye) in order to avoid gluten may be associated with increased heart disease risk. This study has several strengths, including its large size, the fact that data was collected prospectively and diet assessed at several time-points, the long period of follow up, and that it took into account a wide range of potential confounders. As with all studies of this type, it is possible that other factors may affect the results. However, the researc...
Source: NHS News Feed - May 4, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers.
Conclusions. Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H. pylori infection. PMID: 27579036 [PubMed]
Source: Gastroenterology Research and Practice - September 2, 2016 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Wholegrains, not just porridge, may increase life
Conclusion This analysis of two large prospective cohort studies from the US has found an association between higher wholegrain intake and a reduced risk of death during follow-up, particularly from heart disease. The study benefits from its large size (more than 100,000 participants) and long duration, as well as the thorough collection of information on the participants as the study progressed (prospective data collection). Our diets and lifestyles are very complex, and it is very difficult to entirely isolate the effect of one dietary component and remove the effect of all other factors. However, the researchers have ...
Source: NHS News Feed - January 6, 2015 Category: Consumer Health News Tags: Heart/lungs Food/diet Source Type: news

Nut eaters may have a longer life expectancy
Conclusion This study found that eating nuts is associated with a reduced risk of death from any cause, and that the more frequently nuts were eaten, the lower the risk of death. Eating 28g of nuts seven or more times per week was associated with a 20% reduced risk of death. The researchers say that previous studies found that increased nut intake was associated with a reduced risk of several diseases (including type 2 diabetes mellitus, colon cancer, high blood pressure and diverticulitis), and that nut consumption has been linked to reductions in various risk factors for chronic diseases. Seeing whether nut consumption w...
Source: NHS News Feed - November 21, 2013 Category: Consumer Health News Tags: Heart/lungs Food/diet Lifestyle/exercise Source Type: news

Health maintenance in women.
Abstract The health maintenance examination is an opportunity to focus on disease prevention and health promotion. The patient history should include screening for tobacco use, alcohol misuse, intimate partner violence, and depression. Premenopausal women should receive preconception counseling and contraception as needed, and all women planning or capable of pregnancy should take 400 to 800 mcg of folic acid per day. High-risk sexually active women should be counseled on reducing the risk of sexually transmitted infections, and screened for chlamydia, gonorrhea, and syphilis. All women should be screened for huma...
Source: American Family Physician - January 1, 2013 Category: Primary Care Authors: Riley M, Dobson M, Jones E, Kirst N Tags: Am Fam Physician Source Type: research