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Total 125 results found since Jan 2013.

The U.S. Death Rate Rose Significantly During the COVID-19 Pandemic
COVID-19 was the third-most-common cause of death in the U.S. in 2020, contributing to more than 375,000 deaths, and a 16% increase in the national death rate, according to provisional data published today by the U.S. Centers for Disease Control and Prevention (CDC). All told, more than 3.3 million people in the U.S. died in 2020, for a rate of about 829 deaths per 100,000 people. That’s up from about 715 deaths per 100,000 people in 2019. ( function() { var func = function() { var iframe = document.getElementById('wpcom-iframe-cc2cb8dfd195b43a5d43643e9ec19ffa') if ( iframe ) { iframe.onload =...
Source: TIME: Health - March 31, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news

Opportunities and limitations of risk adjustment of quality indicators based on inpatient administrative health data - a workshop report
DISCUSSION: Implementing specific risk adjustment models had only minor effects on the distribution of risk-adjusted mortality compared to the standard procedure, but the judgement of quality of care could change for a fifth of the hospitals in individual indicators. Concerning methodological and practical reasons, the task force recommends further development of risk adjustment methods for selected indicators. This should be accompanied by studies on the validity of inpatient administrative data for quality management as well as by efforts to improve the usefulness of these data for such purposes.PMID:34023246 | DOI:10.10...
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - May 23, 2021 Category: Health Management Authors: Daniel Schwarzkopf Ulrike Nimptsch Raphael Graf Jochen Schmitt Josef Zacher Ralf Kuhlen Source Type: research

Cardiovascular outcomes and rates of fractures and falls among patients with brand-name versus generic L-thyroxine use
ConclusionsWe found no significant differences in cardiovascular outcomes and rates of falls and fractures for patients who filled brand versus generic L-thyroxine.
Source: Endocrine - June 5, 2021 Category: Endocrinology Source Type: research

Relationship of higher-level functional capacity with long-term mortality in Japanese older people: NIPPON DATA90
CONCLUSION: Impaired HLFC was associated with a high risk of all-cause mortality among community-dwelling older people with independent BADL. In particular, social role in men and IADL and intellectual activity in women were associated with long-term mortality risk.PMID:34248110 | DOI:10.2188/jea.JE20210077
Source: Journal of Epidemiology - July 12, 2021 Category: Epidemiology Authors: Hideki Nagata Katsuyuki Miura Sachiko Tanaka Aya Kadota Takehito Hayakawa Keiko Kondo Akira Fujiyoshi Naoyuki Takashima Yoshikuni Kita Akira Okayama Tomonori Okamura Hirotsugu Ueshima Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Couple and family interventions for high mortality health conditions: A strategic review (2010 –2019)
AbstractThe earliest publications in the field of marriage and family therapy introduced interventions conducted with families experiencing complex health conditions. This strategic review captures an evaluation of efficacy for 87 couple and family interventions published between 2010 and 2019 with a focus on the leading causes of mortality in the United States. These health conditions include chromosomal anomalies and accidents with infants aged 0 –4 years; accidents and cancer among children aged 5–14; accidents among adolescents aged 15–24; and heart disease, cancer, accidents, chronic lower respiratory diseases,...
Source: Journal of Marital and Family Therapy - November 6, 2021 Category: Psychiatry & Psychology Authors: Angela L. Lamson, Jennifer L. Hodgson, Keeley J. Pratt, Tai J. Mendenhall, Alison G. Wong, Erin M. Sesemann, Braden J. Brown, Erika S. Taylor, Jacqueline M. Williams ‐Reade, Daniel J. Blocker, Jennifer Harsh Caspari, Max Zubatsky, Matthew P. Tags: ORIGINAL ARTICLE Source Type: research

Association of nutritional support with survival-time in hospitalized older patients with dysphagia: a retrospective study
Dysphagia results from age-related changes in swallowing physiology and contributes to various health status changes, including higher risks for malnutrition, pneumonia, and mortality [1, 2]. It also occurs in age-related diseases, including stroke [3] and cancer [4], and progressive neurological diseases, such as dementia [5] and Parkinson ’s disease [6]. These associations, and global aging, have increased the importance of dysphagia management. Artificial nutrition can support patients with dysphagia caused by various clinical conditions. Percutaneous endoscopic gastrostomy (PEG) is an artificial nutrition method that...
Source: Annals of Nutrition and Metabolism - July 13, 2022 Category: Nutrition Source Type: research

Variable Clinical Features in a Large Family With Diamond Blackfan Anemia Caused by a Pathogenic Missense Mutation in RPS19
Discussion: This large family with DBA demonstrates the heterogeneity of phenotypes that can be seen within the same genotype. Most family members presented with steroid-responsive anemia in infancy and subtle congenital malformations, findings consistent with recent genotype-phenotype studies of RPS DBA. However, two family members were relatively unaffected, underscoring the importance of further studies to assess modifier genes, and epigenetic and/or environmental factors which may result in normal erythropoiesis despite underlying ribosome dysfunction. This large, multigenerational family highlights the need for indivi...
Source: Frontiers in Genetics - July 18, 2022 Category: Genetics & Stem Cells Source Type: research

U.S. FDA Approves TECVAYLI ™ (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
HORSHAM, Pa., October 25, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) approved TECVAYLI™ (teclistamab-cqyv) for the treatment of adult patients with relapsed or refractory multiple myeloma, who previously received four or more prior lines of therapy, including a proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.1 TECVAYLI™ is a first-in-class, bispecific T-cell engager antibody that is administered as a subcutaneous treatment.1 This off-the-shelf (or ready to use) therapy uses innovative science to ac...
Source: Johnson and Johnson - October 25, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

On prioritising global health ' s triple crisis of sepsis, COVID-19 and antimicrobial resistance: a mixed-methods study from Malawi.
Conclusion Our analysis revealed strong relationships between in-hospital mortality and hospital case volume in hospitals treating a small number of cases. The nonlinearity and nonm onotonicity of the estimated relationships indicate that studies applying conventional statistical approaches like logistic regression should consider these relationships adequately.
Source: Current Awareness Service for Health (CASH) - December 14, 2022 Category: Consumer Health News Source Type: news