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Infectious Disease: COVID-19
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Total 5314 results found since Jan 2013.
Ischemic strokes in COVID-19: risk factors, obesity paradox, and distinction between trigger and causal association
ConclusionOur stroke occurrence rate is consistent with other population-based reports (range 0.34–2.7%). Prespecified peculiar clinical and radiological features allow the distinction between “IS caused by COVID-19” and “IS triggered by COVID-19.” Clinical history of vascular diseases and risk factors is crucial in determining the risk of IS in patients with COVID-19. However, the protective effect of a BMI > 30 kg/m2 seems to suggest an obesity paradox.
Source: Frontiers in Neurology - August 1, 2023 Category: Neurology Source Type: research
Protective effect of vaccination on the risk of cardiovascular disease after SARS-CoV-2 infection
ConclusionAlthough COVID-19 increased the CVD risk, the inverse association in the risk of CVDs according to vaccine doses was significant in a dose –response manner. Our findings suggest that ≥ second doses of the COVID-19 vaccine prevent the risk of CVDs after SARS-CoV-2 infection.Graphical abstractIn 2,146,130 infected adults ( ≥ 20 years), the inverse association in the short-term risk of cardiovascular diseases, including coronary heart disease and stroke, according to vaccine doses received was significant in a dose–response manner.
Source: Clinical Research in Cardiology - July 31, 2023 Category: Cardiology Source Type: research
E-086 The effect of covid-19 vaccines on stroke outcomes: a single-center study
ConclusionAlthough vaccination did not show any significant difference in stroke patient outcomes on follow-up, vaccines were associated with lower rates of morbidity and mortality at discharge among stroke patients during the pandemic.Abstract E-086 Table 1Comparison of outcomes between COVID-19-positive unvaccinated vs. fully vaccinated patients presenting with stroke.*Adjusted for hypertension, atrial fibrillation, PVD, admission NIHSS, ASPECTS, tandem occlusion, and thrombectomy Unvaccinated Vaccinated Effect Variable Unadjusted Value (95% CI ) Unadjusted p-value Adjusted Value (95% CI )* Adjusted p-value* Primary Out...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: El Naamani, K., Amllay, A., Chen, C., Capone, S., Abbas, R., Sioutas, G., Munoz, A., Yudkoff, C., Carreras, A., Samabngi, A., Hunt, A., Jain, P., Stine, E., Sathe, A., Smit, R., Yazbeck, F., Tjoumakaris, S., Gooch, M., Herial, N., Rosenwasser, R., Zarzour Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-129 Trends in demographic and geographic disparities of stroke-related mortality in older adults in the United States from 1999 to 2020
Stroke is a leading cause of mortality and morbidity in the United States. Many risk factors are controversial, and their relative importance is not fully understood. Elucidating the association between demographic and geographic disparities and stroke-related mortality in older adults will guide policy to alleviate stroke burden. This retrospective cohort study characterizes stroke-related mortality among individuals aged 55 and older in the United States from January 1999 to December 2020 using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Segmented regressio...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: McCandless, M., Powers, A., Baker, K., Strickland, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-132 Successful mechanical thrombectomy in an 11-year-old patient with emergent large vessel occlusion acute ischemic stroke related to congenital complete heart block and recent covid-19 infection
ConclusionsThis is a first known report of a successful mechanical thrombectomy in a pediatric patient due to a large vessel occlusion related to congenital complete heart block and recent COVID-19 infection.Disclosures J. Ansari: None. D. Mata Canadas: None. M. Ayub: None. J. Caskey: None. P. Simoncini: None. R. Riel-Romero: None. P. Sharma: None. D. Jordan: None. H. Cuellar: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ansari, J., Mata Canadas, D., Ayub, M., Caskey, J., Simoncini, P., Riel-Romero, R., Sharma, P., Jordan, D., Cuellar, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-145 Mortality following mechanical thrombectomy for ischemic stroke in patients with COVID-19
ConclusionOverall, this study indicates that COVID-19 is a predictor of mortality among mechanical thrombectomy. This finding is likely multifactorial but may be related to multisystem inflammation, hypercoagulability, and re-occlusion seen in COVID-19 patients. Treatment-related factors, such as delays in care, may also play a role. Additional research would be needed to further delineate these findings.Disclosures J. Dallas: None. T. Wenger: None. K. Liu: None. L. Ding: None. B. Hopkins: None. F. Attenello: None. W. Mack: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Dallas, J., Wenger, T., Liu, K., Ding, L., Hopkins, B., Attenello, F., Mack, W. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-164 Symptomatic developmental venous anomaly thrombosis associated with covid-19 infection
We describe a milder case of DVA thrombosis in the setting of COVID-19 infection presenting with unilateral hemiparesis requiring medical management alone. A 41-year-old female with hypertension who presented with left hemiparesis. Non-contrast computed tomography (CT) of head revealed linear calcifications in the right centrum semiovale consistent with DVA. Magnetic resonance imaging (MRI) revealed an acute ischemic stroke in the right corona radiata adjacent to the vascular abnormality. Extensive workup for other causes of ischemic stroke was unrevealing. Cerebral angiography ruled out arteriovenous shunting and did not ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Eby, B., Khasawneh, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-166 The effect of covid-19 on treatment and outcomes following ischemic stroke: a national assessment
ConclusionThis study identified a relationship between COVID-19 diagnosis and worse outcomes for each metric assessed. Most notably, even when controlling for disease-related factors, patients with COVID-19 were significantly less likely to undergo mechanical thrombectomy. Further, COVID-19 was associated with increased in-hospital mortality and worsened discharge disposition, although the exact causal relationship of this is unclear. Several factors might underly this, ranging from systemic/multisystem inflammation and worsened disease severity to logistical barriers to treatment caused by COVID-19. Further research is ne...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Dallas, J., Liu, K., Wenger, T., Lin, M., Ding, L., Attenello, F., Mack, W. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-177 Treatment of ischemic stroke in patients diagnosed with covid-19: a matched analysis of the national inpatient sample
ConclusionsIn this matched NIS analysis of patients treated for ischemic stroke with a concomitant COVID diagnosis, we demonstrate that EVT trends towards, although nonsignificant, higher rates of favorable functional outcomes when compared to medically managed patients.Abstract E-177 Table 1Patients with COVID and Acute Ischemic Stroke Comparing medical management vs EVT 1:1 Nearest Neighbor Matching for EVT based on Age, NIHSS, Gender, and Comorbidities Medically Managed N = 495 1 Endovascular ThrombectomyN = 495 1 p-value 2 Age in years at admission 66.82 ± 16.98 (19.00-90.00), (1.77) 65.67 ± 14.81 (28...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Heskett, C., Fry, L., Brake, A., De Stefano, F., Morey, K., Lei, C., Alkiswani, A., Le, K., Peterson, J., Ebersole, K. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
RECREATE: a study protocol for a multicentre pilot cluster randomised controlled trial (cRCT) in UK stroke services evaluating an intervention to reduce sedentary behaviour in stroke survivors (Get Set Go) with embedded process and economic evaluations
This study is a pragmatic, multicentre, two-arm, external pilot cluster randomised controlled trial with embedded process and economic evaluations. UK-based stroke services will be randomised 1:1 to the intervention (usual care plus Get Set Go) or control (usual care) arm. Fifteen stroke services will recruit 300–400 stroke inpatient and carer participants, with follow-up at 6, 12 and 24 months. The proposed primary endpoint is stroke survivor self-reported Nottingham Extended Activities of Daily Living scale at 12 months. Endpoint analyses will be exploratory and provide preliminary estimates of intervention effect....
Source: BMJ Open - July 30, 2023 Category: General Medicine Authors: Airlie, J., Burton, L.-J., Copsey, B., English, C., Farrin, A., Fitzsimons, C. F., Holloway, I., Horrocks, J., Johansson, J. F., Mead, G., Moreau, L. A., Ozer, S., Patel, A., Yaziji, N., Forster, A., on behalf of the RECREATE Programme Management Group, A Tags: Open access, Rehabilitation medicine Source Type: research
E-223 Improved time to diagnosis with portable MR imaging
ConclusionPortable MRI is a promising innovation with the aim to expand patient access and improve diagnostic times so that critical and potential lifesaving imaging diagnoses can be promptly treated with the urgency that is required. While initial analysis provides evidence that portable MRI has advantages over conventional MRI systems including workflow efficiency and improved patient imaging times, this will need to be compared to the unfortunate negative drawbacks of lessened image resolution and limited imaging sequences that come with the convenience of portable MRI systems. If the hypothesis is further corroborated,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Richardson, O., Richardson, A., Mukherjee, S. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
E-241 Clinicopathologic analysis of COVID-19 associated thrombi in the setting of large vessel occlusion: a prospective case control study
ConclusionThrombi retrieved from COVID-19 positive stroke patients demonstrated RBC predominance. This finding requires further investigation using appropriate immunohistochemical techniques in a larger cohort of patients.Abstract E-241 Figure 1Abstract E-241 Figure 2COVID-19 positive patient thrombus; stained with H&E demonstrating predominantly RBCs (solid yellow arrow) with interspersed fibrin (solid black arrow) and platelets. Original magnification X100Disclosures R. Floresca: None. F. Sheriff: None. J. Lavezo: None. M. Chaudhury: None. G. Colina: None. R. Regenhardt: None. V. Gupta: None. G. Rodriguez: None. A. Maud: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Floresca, R., Sheriff, F., Lavezo, J., Chaudhury, M., Colina, G., Regenhardt, R., Gupta, V., Rodriguez, G., Maud, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
P-028 Impact of the covid-19 pandemic on the intracranial aneurysm treatment and associated outcomes: a propensity score matching study
Conclusions and RelevanceThe COVID-19 pandemic has significantly impacted the healthcare system and has led to changes in the treatment of various neurological conditions, including ICAs. The pandemic resulted in a shift in the treatment of SAH and an increase in endovascular procedures over open surgical clipping. COVID-19 infection has been associated with an increased risk of ischemic stroke and worsened outcomes for stroke patients. Further research is necessary to understand the long-term effects of the pandemic on the healthcare system and patient outcomes.Disclosures A. Ghaith: None. M. Ghanem: None. E. Greco: None....
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ghaith, A., Ghanem, M., Greco, E., Rios-Zermeno, J., Bon Nieves, A., Kashyap, S., Tawk, R., Bydon, M. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research
E-069 Covid-19 and mechanical thrombectomy: confounder or contributor
ConclusionLate in the pandemic, mortality rates remain very high for patients with COVID-19 undergoing mechanical thrombectomy. This is significant in that later circulating variants appear to cause less severe disease.Disclosures C. Houk: None. N. Ellens: None. G. Kohli: None. D. Schartz: None. D. Proper: None. T. Bhalla: None. M. Bender: None. T. Mattingly: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Houk, C., Ellens, N., Kohli, G., Schartz, D., Proper, D., Bhalla, T., Bender, M., Mattingly, T. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research
