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Therapy: Antibiotic Therapy
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Total 6680 results found since Jan 2013.
Bacterial metabolism and susceptibility to cell wall-active antibiotics
Adv Microb Physiol. 2023;83:181-219. doi: 10.1016/bs.ampbs.2023.04.002. Epub 2023 May 16.ABSTRACTBacterial infections are increasingly resistant to antimicrobial therapy. Intense research focus has thus been placed on identifying the mechanisms that bacteria use to resist killing or growth inhibition by antibiotics and the ways in which bacteria share these traits with one another. This work has led to the advancement of new drugs, combination therapy regimens, and a deeper appreciation for the adaptability seen in microorganisms. However, while the primary mechanisms of action of most antibiotics are well understood, the ...
Source: Advances in Microbial Physiology - July 28, 2023 Category: Microbiology Authors: Megan Renee Keller Tobias D örr Source Type: research
Hidden consequences: Uncovering belimumab's role in the development of < em > Pneumocystis jirovecii < /em > pneumonia in a lupus patient
DISCUSSION: Our report demonstrates the first confirmed case of pneumocystis jirovecii pneumonia in a patient with B cell depletion due to chronic maintenance therapy with belimumab. Our patient's diagnosis of PJP was unexpected, given her normal CD4+ count and the use of such a low dose of prednisone. We attribute her susceptibility to PJP infection to her profound B cell depletion in response to her belimumab therapy, supporting previous research indicating the importance of CD4+ T cells and B cells in the protective immune response against PJP. This case may help shape future clinical guidelines concerning PJP prophylax...
Source: Lupus - July 27, 2023 Category: Rheumatology Authors: Maria Ng Meggan Mackay Pranisha Gautam-Goyal Sameer Goyal Praveen Kumar Vikraman Source Type: research
Experience with the Biofire FilmArray ® for infectious meningitis/encephalitis in a high complexity institution in Bogota, Colombia
CONCLUSIONS: The result of the FAME panel for testing in CSF has a high impact on antimicrobial therapeutic decisions within 24 hours of clinical assessment. However, it must be interpreted with the clinical context, local epidemiology and other diagnostic studies.PMID:37489856 | DOI:10.33588/rn.7704.2023082
Source: Revista de Neurologia - July 25, 2023 Category: Neurology Authors: C A Romero-Hern ández J L Zuleta-Motta N M Zapa-P érez J D Mart ínez-Lemus Source Type: research
