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Total 12097 results found since Jan 2013.
Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease
CONCLUSION: Our findings suggest that the investigated OMLs are associated with high-risk coronary plaque features and progression over time in CVD patients.TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov. Unique identifier: NCT01621594.FUNDING: This work was supported by the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health Intramural Research Program. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript f...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Alexander V Sorokin Christin G Hong Angel M Aponte Elizabeth M Florida Jingrong Tang Nidhi Patel Irina N Baranova Haiou Li Philip M Parel Vicky Chen Sierra R Wilson Emily L Ongstad Anna Coll én Martin P Playford Thomas L Eggerman Marcus Y Chen Kazuhiko K Source Type: research
Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in type 1 diabetes and type 2 diabetes: Lipid goal attainment in a large German-Austrian diabetes registry
CONCLUSION: Approximately 2 years after publication of the guidelines, LDL-C and non-HDL-C goal attainment was rarely achieved in patients with T1D and T2D with a high or very high cardiovascular risk.PMID:37694759 | DOI:10.1111/dom.15264
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Julia Brandts Sascha R Tittel Peter Bramlage Thomas Danne Johanna M Brix Stefan Zimny Christoph H J Heyer Reinhard W Holl Dirk M üller-Wieland Source Type: research
Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis
Mol Ther Methods Clin Dev. 2023 Aug 22;30:558-572. doi: 10.1016/j.omtm.2023.08.018. eCollection 2023 Sep 14.ABSTRACTCoronary artery venous bypass grafts typically fail because of atherosclerosis driven by lipid and macrophage accumulation. Therapy for vein-graft atherosclerosis is limited to statin drugs, which are only modestly effective. We hypothesized that transduction of vein-graft endothelium of fat-fed rabbits with a helper-dependent adenovirus expressing apolipoprotein AI (HDAdApoAI) would reduce lipid and macrophage accumulation. Fat-fed rabbits received bilateral external jugular vein-to-carotid artery interposit...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Lianxiang Bi Bradley K Wacker Kaushik Komandur Nicole Sanford David A Dichek Source Type: research
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, In Vivo Efficacy, and Safety Assessment
In this study, we conducted a screening of drug combinations, including sorafenib (SOR) with simvastatin (SIM), phenethyl isothiocyanate, and trigonelline, in MDA-MB-231, A549, and HeLa cells to assess their cytotoxicity. The SOR-SIM combination exhibited a synergistic effect in MDA-MB-231, A549, and HeLa cells, with calculated CI values of ~ 0.66, 0.53, and 0.59, respectively. Furthermore, co-treatment with ferrostatin-1 resulted in a concentration-dependent increase in the IC50 values. Additionally, SOR + SIM demonstrated a significant reduction in GSH levels, an increase in MDA levels, and mitochondrial membrane depolar...
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Kaushik Kuche Vivek Yadav Meet Patel Rohan Ghadi Sanyog Jain Source Type: research
Statins improve endothelial function via suppression of epigenetic-driven EndMT
Nat Cardiovasc Res. 2023 May;2(5):467-485. doi: 10.1038/s44161-023-00267-1. Epub 2023 May 8.ABSTRACTThe pleiotropic benefits of statins in cardiovascular diseases that are independent of their lipid-lowering effects have been well documented, but the underlying mechanisms remain elusive. Here we show that simvastatin significantly improves human induced pluripotent stem cell-derived endothelial cell functions in both baseline and diabetic conditions by reducing chromatin accessibility at transcriptional enhanced associate domain elements and ultimately at endothelial-to-mesenchymal transition (EndMT)-regulating genes in a ...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Chun Liu Mengcheng Shen Wilson L W Tan Ian Y Chen Yu Liu Xuan Yu Huaxiao Yang Angela Zhang Yanxia Liu Ming-Tao Zhao Mohamed Ameen Mao Zhang Eric R Gross Lei S Qi Nazish Sayed Joseph C Wu Source Type: research
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, In Vivo Efficacy, and Safety Assessment
In this study, we conducted a screening of drug combinations, including sorafenib (SOR) with simvastatin (SIM), phenethyl isothiocyanate, and trigonelline, in MDA-MB-231, A549, and HeLa cells to assess their cytotoxicity. The SOR-SIM combination exhibited a synergistic effect in MDA-MB-231, A549, and HeLa cells, with calculated CI values of ~ 0.66, 0.53, and 0.59, respectively. Furthermore, co-treatment with ferrostatin-1 resulted in a concentration-dependent increase in the IC50 values. Additionally, SOR + SIM demonstrated a significant reduction in GSH levels, an increase in MDA levels, and mitochondrial membrane depolar...
Source: AAPS PharmSciTech - September 11, 2023 Category: Drugs & Pharmacology Authors: Kaushik Kuche Vivek Yadav Meet Patel Rohan Ghadi Sanyog Jain Source Type: research
Administration of andexanet alfa for traumatic intracranial hemorrhage in the setting of massive apixaban overdose: A case report
CONCLUSION: This case suggests that andexanet alfa may have a role in the management of traumatic hemorrhage in the setting of an acute massive apixaban overdose. Use of andexanet alfa, PCC, and aPCC in this context requires further research.PMID:37688311 | DOI:10.1093/ajhp/zxad215
Source: American Journal of Health-System Pharmacy : AJHP - September 9, 2023 Category: Drugs & Pharmacology Authors: Daniel Jenniches Abigail F Kerns John DelBianco Matthew P Stripp Allan S Philp Source Type: research
Use of Apolipoprotein B in the Era of Precision Medicine: Time for a Paradigm Change?
J Clin Med. 2023 Sep 3;12(17):5737. doi: 10.3390/jcm12175737.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and the risk of a major cardiovascular event is highest among those with established disease. Ongoing management of these patients relies on the accurate assessment of their response to any prescribed therapy, and their residual risk, in order to optimize treatment. Recent international guidelines and position statements concur that the plasma concentration of apolipoprotein B (apoB) is the most accurate measure of lipoprotein associated ASCVD risk. This is especia...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Justine Cole Rafael Zubir án Anna Wolska Ishwarlal Jialal Alan T Remaley Source Type: research
Targeting pharmacotherapies for inflammatory and cardiorenal endpoints in kidney disease
J Cardiovasc Pharmacol. 2023 Sep 5. doi: 10.1097/FJC.0000000000001482. Online ahead of print.ABSTRACTInflammation is an important contributor to excess cardiovascular risk and progressive renal injury in people with CKD. Dysregulation of the innate and adaptive immune system is accelerated by CKD and results in increased systemic inflammation, a heightened local vascular inflammatory response leading to accelerated atherosclerosis, and dysfunction of the cardiac and renal endothelium and microcirculation. Understanding and addressing the dysregulated immune system is a promising approach to modifying cardiorenal outcomes i...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Daniel M Huck Leo F Buckley Anil Chandraker Ron Blankstein Brittany Weber Source Type: research
Elucidation of the melitidin biosynthesis pathway in pummelo
This study establishes a biosynthetic pathway for melitidin, which provides genetic resources for the breeding and genetic improvement of pummelo aimed at fortifying the content of biologically active metabolites. This article is protected by copyright. All rights reserved.PMID:37675654 | DOI:10.1111/jipb.13564
Source: Journal of Integrative Plant Biology - September 7, 2023 Category: Biology Authors: Shuangqian Shen Shouchuang Wang Chenkun Yang Chao Wang Qianqian Zhou Shen Zhou Ran Zhang Yufei Li Zixuan Wang Liupan Dai Wenjv Peng Yingchen Hao Hao Guo Guangping Cao Xianqing Liu Fan Yao Qiang Xu Alisdair R Fernie Jie Luo Source Type: research
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
In this study, we determined cryo-EM structures of human OATP1B1 bound with representative endogenous metabolites (bilirubin and estrone-3-sulfate), a clinical drug (simeprevir), and a fluorescent indicator (2',7'-dichlorofluorescein), in both outward- and inward-open states. These structures reveal major and minor substrate binding pockets and conformational changes during transport. In combination with mutagenesis studies and molecular dynamics simulations, our work comprehensively elucidates the transport mechanism of OATP1B1 and provides the structural basis for DDI predictions involving OATP1B1, which will greatly pro...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Ziyang Shan Xuemei Yang Huihui Liu Yafei Yuan Yuan Xiao Jing Nan Wei Zhang Wenqi Song Jufang Wang Feiwen Wei Yanqing Zhang Source Type: research
Bempedoic Acid can Reduce Cardiovascular Events in Combination with Statins or As Monotherapy: A Systematic Review and Meta-analysis
ConclusionBempedoic acid may reduce the risk of cardiovascular events regardless of whether the patient is taking stains or not.Registration: PROSPERO registration number CRD42023422932.
Source: American Journal of Cardiovascular Drugs - September 6, 2023 Category: Cardiology Source Type: research
