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Specialty: Cancer & Oncology
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Total 129106 results found since Jan 2013.
Which Patients With Rhabdomyosarcoma Need Radiotherapy? Analysis of the Radiotherapy Strategies of the CWS-96 and CWS-2002P Studies and SoTiSaR Registry
CONCLUSION: RT can be omitted in patients with IRS I eRMS. RT improves LCS and EFS in IRS II and III. RT improves OS in patients with HN-PM, with proton RT comparable with photon RT. Doses of 32 Gy (HART) or 36 and 41.4 Gy (CFRT) had comparable efficacy in patients with favorable risk profiles and 44.8 Gy (HART) or 50.4 and 55.8 Gy (CFRT) in the unfavorable groups.PMID:37725766 | DOI:10.1200/JCO.22.02673
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Ewa Koscielniak Beate Timmermann Marc M ünter Jadwiga Weclawek-Tompol Ruth Ladenstein Felix Niggli Gustaf Ljungman Ines B Brecht Bernd Blank Erika Hallmen Monika Scheer Joerg Fuchs Guido Seitz Claudia Blattmann Monika Sparber-Sauer Thomas Klingebiel Source Type: research
Time trends in systemic treatment for patients with metastatic prostate cancer: a national cohort study
CONCLUSIONS: An increasing proportion of patients received systemic treatment during the period 2010-18. However, less than 50% of patients in our study received systemic treatment. In accordance with updated guidelines, Docetaxel was introduced after 2015 with an increasing proportion of patients receiving systemic treatment as mHSPC. Further studies should address the disease course and treatment given to patients who do not receive systemic treatment.PMID:37725527 | DOI:10.1080/0284186X.2023.2257876
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Anne Holck Stor ås Kaitlyn Tsuruda Sophie Dorothea Foss å Bettina Kulle Andreassen Source Type: research
Working Memory Training for Children Using the Adaptive, Self-Select, and Stepwise Approaches to Setting the Difficulty Level of Training Activities: Protocol for a Randomized Controlled Trial
CONCLUSIONS: This trial will determine whether the adaptive approach to setting the difficulty of training activities maximizes cognitive training outcomes for children. This trial has several strengths: it adopts best practices for cognitive training studies (design, methods, and analysis plan); uses a range of measures to detect discrete levels of transfer; has a 6-month postintervention assessment; is appropriately powered; and uses an experimental working memory training intervention based on our current understanding of the cognitive mechanisms of training. Findings will inform future research and design of cognitive ...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Regine Cassandra Lau Peter John Anderson Joshua F Wiley Derek Huang Faisha Surjatin Paul McIntosh Susan Gathercole Megan Spencer-Smith Source Type: research
Ranitidine Use and Incident Cancer in a Multinational Cohort
CONCLUSIONS AND RELEVANCE: In this cohort study, ranitidine use was not associated with an increased risk of cancer compared with the use of other H2RAs. Further research is needed on the long-term association of ranitidine with cancer development.PMID:37725377 | DOI:10.1001/jamanetworkopen.2023.33495
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Seng Chan You Seung In Seo Thomas Falconer Chen Yanover Talita Duarte-Salles Sarah Seager Jose D Posada Nigam H Shah Phung-Anh Nguyen Yeesuk Kim Jason C Hsu Mui Van Zandt Min-Huei Hsu Hang Lak Lee Heejoo Ko Woon Geon Shin Nicole Pratt Rae Woong Park Chris Source Type: research
Suppression of TBCK enhances TRAIL-mediated apoptosis by causing the inactivation of the akt signaling pathway in human renal carcinoma Caki-1 cells
CONCLUSIONS: These data suggest that TBCK could potentially have a crucial function in influencing the effects of anti-cancer drugs including TRAIL by modulating the signaling pathway involving Akt and PDK1 in human renal cancer cells.PMID:37725269 | DOI:10.1007/s13258-023-01453-y
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Cho-Young Park Ji-Hoon Jang In-Hwan Song Joo-Young Kim Kyung-Oh Doh Tae-Jin Lee Source Type: research
Therapeutic potential of rWnt5A in curbing < em > Leishmania donovani < /em > infection
Infect Immun. 2023 Sep 19:e0026723. doi: 10.1128/iai.00267-23. Online ahead of print.ABSTRACTIn view of the antagonism of Wnt5A signaling toward microbial pathogens, we were interested in evaluating the therapeutic potential of recombinant Wnt5A (rWnt5A) in curbing Leishmania donovani infection. Initially, using L. donovani-infected RAW 264.7 and peritoneal macrophages, we demonstrated that application of rWnt5A as opposed to the vehicle control to the infected cells significantly dampens L. donovani infection. Inhibition of infection was associated with increase in cell-associated reactive oxygen species (ROS), and blocke...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Shreyasi Maity Soham Sengupta Malini Sen Source Type: research
Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-associated Immunity in Lynch Syndrome
CONCLUSIONS: Together these data have important implications for cancer interception in LS, and document for the first-time biological effects of exercise in the immune system of a target organ in patients at-risk for cancer.PMID:37724990 | DOI:10.1158/1078-0432.CCR-23-0088
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Nan Deng Laura Reyes-Uribe Johannes F Fahrmann Whittney S Thoman Mark F Munsell Jennifer B Dennison Eunice Murage Ranran Wu Ernest T Hawk Selvi Thirumurthi Patrick M Lynch Christina M Dieli-Conwright Alexander J Lazar Sonali Jindal Khoi Chu Manoj Chelvana Source Type: research
Evaluation of genetic variants in ferroptosis-related genes and house dust mite-induced allergic rhinitis risk
CONCLUSIONS: These findings suggest that the genetic variants in ferroptosis-related genes ENPP2 and EPAS1 may increase HDM-induced AR risk and serve as potential predictors of HDM-induced AR susceptibility.PMID:37724950 | DOI:10.1016/j.intimp.2023.109707
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Yi-Fan Yang Rui Zheng Xiang Gu Fang Gao Min Chen Mu-Long Du Zheng-Dong Zhang Mei-Ping Lu Lei Cheng Source Type: research
A Predictive Model for the Early Death of Breast Cancer With Synchronous Liver Metastases: A Population-Based Study
CONCLUSIONS: Valuable insights into the prognosis of BCLM patients were provided, and important prognostic factors for early death were identified. The developed nomogram can assist clinicians in identifying high-risk patients for early death and inform treatment decisions.PMID:37724916 | DOI:10.1177/10732748231202851
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Shaochun Liu Yingxue Jia Jiaying Chai Han Ge Runze Huang Anlong Li Huaidong Cheng Source Type: research
Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Nanoscale. 2023 Sep 19. doi: 10.1039/d3nr02816j. Online ahead of print.ABSTRACTLocalized heat generation from manganese iron oxide nanoparticles (MIONPs) conjugated with chemotherapeutics under the exposure of an alternating magnetic field (magneto-chemotherapy) can revolutionize targeted breast cancer therapy. On the other hand, the lack of precise control of local temperature and adequate MIONP distribution in laboratory settings using the conventional two-dimensional (2D) cellular models has limited its further translation in tumor sites. Our current study explored advanced 3D in vitro tumor models as a promising altern...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Satish S Phalake Sandeep B Somvanshi Syed A M Tofail Nanasaheb D Thorat Vishwajeet M Khot Source Type: research
Effect of interferon- α on COVID-19 in-hospital mortality: a large-scale propensity score-matched study
CONCLUSION: Our findings indicate that subcutaneous administration of IFN-α, with or without remdesivir, does not have any significant impact on COVID-19 mortality and ICU admission. Future clinical trials considering the time, subtype, and form of IFN-α administration are warranted to investigate the potential therapeutic effects of IFN-α on COVID-19.PMID:37724852 | DOI:10.1684/ecn.2023.0485
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Mohamad Amin Pourhoseingholi Amirreza Rafiei Javazm Naghmeh Asadimanesh Fatemeh Shojaeian Mehdi Azizmohammad Looha Seyed Amir Ahmad Safavi-Naini Benyamin Mohammadzadeh Parnian Jamshidi Fatemeh Gholampoor Omid Yazdani Nadia Zameni Zahra Azizan Amirhossein Source Type: research
Qualitative study of Oncology Clinicians' Perceptions of Barriers to Offering Clinical Trials to Underserved Populations
CONCLUSION: Findings reveal multi-level barriers to offering cancer clinical trials to underrepresented patients. Targeted solutions, including system level changes to support clinicians, patient financial support, and implementation of clinical trial navigation programs were recommended to help reduce access barriers and increase enrollment of underrepresented patients into cancer clinical trials.PMID:37724824 | DOI:10.1177/10732748231187829
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Giselle K Perez Anjali R Oberoi Lucy Finkelstein-Fox Elyse R Park Ryan D Nipp Beverly Moy Source Type: research
Effectiveness of integrated approach of yoga therapy versus usual care in management on chronic low back pain patients: A randomized controlled pilot study
CONCLUSION: IAYT therapy helped in addressing the psychological components of pain and improved quality of life patients with chronic low back pain compared with usual care.PMID:37724772 | DOI:10.1111/papr.13296
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Spoorthi Poojari Deepanshu Dhiman Babita Ghai Deepali Mathur Kashinath Metri Ketan Kataria Akshay Anand Source Type: research
Impact of Photon-Counting Detector Computed Tomography on Image Quality and Radiation Dose in Patients With Multiple Myeloma
CONCLUSION: Whole-body PCD-CT provides significantly higher subjective and objective image quality at significantly reduced radiation doses than the current clinical standard EID-CT protocols, along with readily available multi-spectral data, facilitating the potential for further advanced post-processing.PMID:37724589 | DOI:10.3348/kjr.2023.0211
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Alexander Rau Jakob Neubauer Laetitia Taleb Thomas Stein Till Schuermann Stephan Rau Sebastian Faby Sina Wenger Monika Engelhardt Fabian Bamberg Jakob Weiss Source Type: research
Comparative Analysis of First-Line FOLFOX Treatment With and Without Anti-VEGF Therapy in Metastatic Colorectal Carcinoma: A Real-World Data Study
CONCLUSION: Our real-world data analysis suggests that the addition of anti-VEGF to FOLFOX offers limited and short-lived benefits in the context of mCRC and may provide differential survival benefit based on tumor sidedness.PMID:37724508 | DOI:10.1177/10732748231202470
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Ronen Brenner Shlomit Amar-Farkash Avital Klein-Brill Keren Rosenberg-Katz Dvir Aran Source Type: research
