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Source: Molecular Medicine Reports
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Total 425 results found since Jan 2013.
CD-PLLD co-delivering docetaxel and MMP-9 siRNA plasmid for nasopharyngeal carcinoma therapy in vivo.
CD-PLLD co-delivering docetaxel and MMP-9 siRNA plasmid for nasopharyngeal carcinoma therapy in vivo.
Mol Med Rep. 2017 Jun 07;:
Authors: Liu T, Wu X, Wang Y, Hou X, Jiang G, Wu T, Xie H, Xie M
Abstract
The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interfering RNA, via CD‑PLLD/DOC/MMP‑9 complexes, into mice implanted with HN...
Source: Molecular Medicine Reports - October 29, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Autophagy is essential for flavopiridol ‑induced cytotoxicity against MCF‑7 breast cancer cells.
Autophagy is essential for flavopiridol‑induced cytotoxicity against MCF‑7 breast cancer cells.
Mol Med Rep. 2017 Oct 17;:
Authors: Wang S, Wang K, Wang H, Han J, Sun H
Abstract
Flavopiridol (FP) exerts antitumoral effects by triggering tumor cell cycle arrest and cytotoxicity in human breast cancer cell lines. The potent antitumor activity of FP is through its inhibition of cyclin‑dependent kinases; however, this may not be the only mechanism of action. The present study aimed to investigate whether FP is able to induce autophagy and to examine the effects of autophagy on cell death in FP‑trea...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Downregulation of caspase ‑3 alleviates Mycoplasma pneumoniae‑induced apoptosis in alveolar epithelial cells.
Downregulation of caspase‑3 alleviates Mycoplasma pneumoniae‑induced apoptosis in alveolar epithelial cells.
Mol Med Rep. 2017 Oct 12;:
Authors: Shi S, Liu X, Li H
Abstract
Mycoplasma pneumoniae (M. pneumoniae) infection is closely associated with pneumonia in children. Apoptosis of alveolar epithelial cells is involved in the development of pneumonia in children. The present study aimed to examine how caspase‑3 influences apoptosis rates in M. pneumoniae‑infected alveolar epithelial cells. A549 alveolar epithelial cells were treated with M. pneumoniae, and cells and culture supernatant we...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Oxidized low density lipoprotein facilitates tumor necrosis factor ‑α mediated chondrocyte death via autophagy pathway.
Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway.
Mol Med Rep. 2017 Oct 13;:
Authors: Shen P, Zhu Y, Zhu L, Weng F, Li X, Xu Y
Abstract
We aimed to investigate the role of oxidized low density lipoprotein (ox‑LDL) in tumor necrosis factor‑α (TNF‑α) mediated chondrocyte death and explore the mechanisms. Ten osteoarthritis (OA) and normal control cartilage tissue and synovial fluid (SF) samples were collected, and the expression of lectin‑like ox‑LDL receptor‑1 (LOX‑1) and ox‑LDL level was examined by real time quan...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Co ‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Mol Med Rep. 2017 Oct 11;:
Authors: Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, Guo R, Cai Y, Liu Y, Li Y
Abstract
The therapeutic options available for the treatment of advanced non-small cell lung cancer have increased over the past decade. Small molecule gene therapy has emerged as an effective therapy for the treatment of lung cancer in vitro and in vivo although it has not been tested in a clinical setting. In particular, therapies that target the negative feedback loop between p53 an...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SiRNA directed against NF ‑κB inhibits mononuclear macrophage cells releasing proinflammatory cytokines in vitro.
SiRNA directed against NF‑κB inhibits mononuclear macrophage cells releasing proinflammatory cytokines in vitro.
Mol Med Rep. 2017 Oct 04;:
Authors: Wu C, Zhao J, Zhu G, Huang Y, Jin L
Abstract
Acute lung injury (ALI) is a condition of acute respiratory failure, characterized by diffuse pulmonary infiltrates and severe hypoxemia. During ALI, the acute phase of inflammation induces the recruitment of activated inflammatory cells, including macrophages and lymphocytes, to the damaged lesions. Nuclear factor (NF)‑κB is a key protein in many signal transduction pathways, over‑activation of which i...
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Effect of miR ‑146a‑5p on tumor growth in NSCLC using chick chorioallantoic membrane assay and bioinformatics investigation.
Effect of miR‑146a‑5p on tumor growth in NSCLC using chick chorioallantoic membrane assay and bioinformatics investigation.
Mol Med Rep. 2017 Oct 04;:
Authors: Huang WT, Cen WL, He RQ, Xie Y, Zhang Y, Li P, Gan TQ, Chen G, Hu XH
Abstract
Our previous study demonstrated that the expression of miR‑146a‑5p was downregulated in non‑small cell lung cancer (NSCLC) tissue, which affected the progression and prognosis of patients with NSCLC. Thus, the present study was conducted to investigate the functional mechanism of miR‑146a‑5p in tumorigenesis and angiogenesis in NSCLC. Following the constr...
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Diagnostic and prognostic value of serum interleukin ‑16 in patients with gastric cancer.
In conclusion, the current results indicate that serum IL‑16 levels may have diagnostic and prognostic value for patient with GC.
PMID: 28990054 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Direct binding of RNF8 to SUMO2/3 promotes cell survival following DNA damage.
Authors: Liang L, Zhang Z, Li J, Wu J, Wang L, Huang W, Gao S
Abstract
Ring finger protein 8 (RNF8), an FHA/RING domain containing E3 ubiquitin ligase, is critical in supporting genome integrity by facilitating the assembly of multiple DNA repair proteins at DNA lesions following DNA damage. In the present study, a search for novel binding partners of RNF8 was performed using a yeast two‑hybrid screening assay, and small ubiquitin‑like modifier (SUMO)2/3 was identified as one of the major RNF8‑binding candidates. GST pull‑down and immunoprecipitation assays revealed that RNF8 bound directly and noncovalentl...
Source: Molecular Medicine Reports - October 7, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Mol Med Repjournal; +111 new citations
111 new pubmed citations were retrieved for your search.
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Mol Med Rep[journal]
These pubmed results were generated on 2017/09/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Molecular Medicine Reports - September 27, 2017 Category: Molecular Biology Tags: Report Source Type: research
Mol Med Repjournal; +117 new citations
117 new pubmed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:
Mol Med Rep[journal]
These pubmed results were generated on 2017/09/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Molecular Medicine Reports - September 14, 2017 Category: Molecular Biology Tags: Report Source Type: research
Mol Med Repjournal; +183 new citations
183 new pubmed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:
Mol Med Rep[journal]
These pubmed results were generated on 2017/08/31PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Molecular Medicine Reports - August 31, 2017 Category: Molecular Biology Tags: Report Source Type: research
TRPC1 stimulates calcium ‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells.
TRPC1 stimulates calcium‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells.
Mol Med Rep. 2017 Aug 04;:
Authors: Qu YY, Wang LM, Zhong H, Liu YM, Tang N, Zhu LP, He F, Hu QH
Abstract
Store‑operated Ca2+ entry (SOCE) via store‑operated Ca2+ channels (SOCC), encoded by transient receptor potential canonical (TRPC) channel proteins, is an important underlying mechanism regulating intracellular Ca2+ concentration ([Ca2+]i) and various intracellular functions in endothelial cells (ECs). TRPC1, the probable candidate for SOCC, is expressed in ECs. Ca...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer.
Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer.
Mol Med Rep. 2017 Aug 03;:
Authors: Su JC, Hu XF
Abstract
Breast cancer is one of the most frequently occurring malignancies in female cancers worldwide, however, its detailed mechanism of tumorigenesis remains to be elucidated. Long non-coding RNAs (LncRNAs) have previously been demonstrated to be important in multiple cancers, including breast cancer. The present study aimed to elucidate the molecular mechanism of the effects of the novel Lnc RNA HOXA11‑AS, on cell proliferation and metastasis in br...
Source: Molecular Medicine Reports - August 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Suppression of TAFI by siRNA inhibits invasion and migration of breast cancer cells.
Authors: Yu C, Luan Y, Wang Z, Zhao J, Xu C
Abstract
Human thrombin activatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2), is a procarboxypeptidase enzyme. The purpose of the present study was to observe the expression of TAFI in breast cancer (BC) and breast cancer cell (BCC) lines and to investigate the effect of TAFI suppression by small interfering (si)RNA gene silencing on invasion and migration of BCC lines. A significant increase in TAFI level was identified by immunohistochemical analysis in BC tissues compared with normal breast tissues. TAFI suppression also inhibited cell vi...
Source: Molecular Medicine Reports - August 4, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
