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MicroRNA ‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim.
MicroRNA‑25‑3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim. Mol Med Rep. 2020 Sep 02;: Authors: Zhao Z, Zheng J, Ye Y, Zhao K, Wang R, Wang R Abstract Intervertebral disc degeneration (IDD) is a degenerative disease of the spine originating from the intervertebral disc. MicroRNAs (miRNAs or miRs) are a group of endogenous small non‑coding RNAs that act on target genes and play a critical role in numerous biological processes. However, the underlying mechanism of miR‑25‑3p in IDD remains unclear. Therefore, the present ...
Source: Molecular Medicine Reports - September 10, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll ‑like receptor 2/4 signaling pathways.
RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll‑like receptor 2/4 signaling pathways. Mol Med Rep. 2020 Jun 16;: Authors: Huang W, Yang J, He C, Yang J Abstract The revascularization of blood vessels after myocardial infarction can lead to serious myocardial damage. Previous studies showed that radioprotective 105 kDa protein (RP105) is a specific negative regulator of myocardial ischemia reperfusion injury (MIRI). RP105 can modulate the Toll‑like receptor (TLR)2/TLR4 signaling pathways. However, the synergistic effect of TLR2/4 regulated by RP1...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA ‑34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression.
MicroRNA‑34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression. Mol Med Rep. 2020 Jun 15;: Authors: Yin W, Gao F, Zhang S Abstract MicroRNAs (miRs) are potential therapeutic targets for tumors. The aims of the present study were to investigate the regulatory effects of miR‑34a on the proliferation, apoptosis and chemosensitivity of retinoblastoma (RB) cells, and to identify the possible underlying mechanism involving Notch1. It was found that miR‑34a was downregulated, and Notch1 was upregulated in HXO‑RB44 and Y79 cells. In...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Troxerutin attenuates oxygen ‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes.
Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes. Mol Med Rep. 2020 Jun 03;: Authors: Yu ZP, Yu HQ, Li J, Li C, Hua X, Sheng XS Abstract Myocardial ischemia‑reperfusion (MI/R) injury is a complex pathological process that occurs when tissues are reperfused following a prolonged period of ischemia. Troxerutin has been reported to have cardioprotective functions. However, the underlying mechanism by which troxerutin protects against MI/R injury has not been fully ...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Downregulation of miR ‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2.
Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2. Mol Med Rep. 2020 Apr 24;: Authors: Wu W, Shang Y, Dai S, Yu C, Wang J Abstract The increased proliferation and migration of vascular smooth muscle cells (VSMCs) are critical in the progression of atherosclerosis (AS). Platelet‑derived growth factor type BB (PDGF‑BB) may induce VSMC proliferation and migration. miR‑142‑5p plays a critical role in various biological processes, including tumorigenesis, angiogenesis and inflammation. However, whether miR‑142‑5p is involved ...
Source: Molecular Medicine Reports - July 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis.
In conclusion, CDK1, BUB1, BUB1B, CENPA and GNG3 were found to be potential biomarkers for GBM. Additionally, 'cell cycle' and 'γ‑aminobutyric acid signaling' pathways may serve a significant role in the pathogenesis of GBM. PMID: 32467990 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - May 31, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

HIF ‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions.
HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions. Mol Med Rep. 2020 Apr 01;: Authors: Zhang Z, Huang C, Wang P, Gao J, Liu X, Li Y, Yan S, Shi Y Abstract Preeclampsia (PE) is a pregnancy-specific syndrome that has severe implications on perinatal mortality and morbidity. Excessive apoptosis of trophoblasts induced by hypoxia may be associated with the development of PE, but the exact pathogenesis is unknown. Forkhead box O transcription factor 3a (FOXO3a) is activated under hypoxic conditions. Furthermore, hypoxia‑inducib...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Circular RNA Circ100084 functions as sponge of miR ‑23a‑5p to regulate IGF2 expression in hepatocellular carcinoma.
Circular RNA Circ100084 functions as sponge of miR‑23a‑5p to regulate IGF2 expression in hepatocellular carcinoma. Mol Med Rep. 2020 Apr 10;: Authors: Yang J, Li Y, Yu Z, Zhou Y, Tu J, Lou J, Wang Y Abstract Hepatocellular carcinoma (HCC) has become a major cause of cancer‑related mortality worldwide. Circular RNAs (circRNAs) are non‑coding RNAs that serve important roles in multiple cancers. However, the role of circRNAs in HCC remains largely unknown. In the present study, a circRNA microarray dataset of HCC samples, GSE97332, was downloaded from the gene expression omnibus database. Followi...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mechanisms of impaired pancreatic β‑cell function in high‑fat diet‑induced obese mice: The role of endoplasmic reticulum stress.
Authors: Yi X, Cai X, Wang S, Xiao Y Abstract The aim of the study was to examine whether there was excessive endoplasmic reticulum stress (ERs) in the islets of high‑fat diet (HFD)‑induced obese mice, as well as the effects of ERs on β‑cell function. Male C57BL/6J mice were fed a HFD for 16 weeks. Pancreatic β‑cell function was evaluated using intraperitoneal glucose tolerance and insulin release tests, and via electron microscopy. The expression of activating transcription factor 6 (ATF6) and phosphorylated (p)‑eukaryotic initiation factor 2α (eIF2α) were detected via immunofluorescence staining to...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in  vitro.
AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in vitro. Mol Med Rep. 2020 Jan 31;: Authors: Zong L, Zhao J, Wu W, Wang J, Huang D, Liu M Abstract The underlying mechanism involved in auditory neuropathy spectrum disorder (ANSD) remains largely unclear. It has been previously reported that mutations in the apoptosis‑inducing factor (AIF) gene are associated with auditory neuropathy and delayed peripheral neuropathy, which can eventually cause ANSD. In the present study, the regulatory effects of AIF knockdown on the cellular functions of spiral gangl...
Source: Molecular Medicine Reports - April 24, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

In  vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy.
In vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy. Mol Med Rep. 2020 Jan 31;: Authors: Zhao L, Sun L, Zheng X, Liu J, Zheng R, Yang R, Wang Y Abstract The mechanism underlying the potential risk associated with in vitro fertilization and embryo transfer (IVF‑ET) has been previously investigated but remains to be fully elucidated. As the placenta is a critical organ that sustains and protects the fetus, this is an important area of research. The aim of the present study was to determine the difference in trophoblast cell function in th...
Source: Molecular Medicine Reports - April 24, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

PDGFD induces ibrutinib resistance of diffuse large B ‑cell lymphoma through activation of EGFR.
PDGFD induces ibrutinib resistance of diffuse large B‑cell lymphoma through activation of EGFR. Mol Med Rep. 2020 Mar 12;: Authors: Jin J, Wang L, Tao Z, Zhang J, Lv F, Cao J, Hu X Abstract Ibrutinib, an FDA approved, orally administered BTK inhibitor, has demonstrated high response rates to diffuse large B‑cell lymphoma (DLBCL), however, complete responses are infrequent and acquired resistance to BTK inhibition can emerge. The present study investigated the role of the platelet‑derived growth factor D (PDGFD) gene and the ibrutinib resistance of DLBCL in relation to epidermal growth factor rece...
Source: Molecular Medicine Reports - March 19, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway.
In conclusion, laminin α5 could modulate fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway. PMID: 32016453 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - February 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF ‑κB signaling pathway in glomerular mesangial cells.
In conclusion, BAFF enhanced the expression of fibroblast factors in the kidneys by activating the TRAF6/NF‑κB signaling pathway. PMID: 31974601 [PubMed - in process]
Source: Molecular Medicine Reports - January 26, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of hub genes and key pathways of dietary advanced glycation end products ‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments.
Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020 Feb;21(2):685-694 Authors: Wang J, Liu H, Xie G, Cai W, Xu J Abstract Non‑alcoholic fatty liver disease (NAFLD) is a common chronic liver disease. Advanced glycation end products (AGEs) negatively affect the liver and accelerate NAFLD progression; however, the underlying mechanisms remain unclear. The present study aimed to examine the effect and mechanism of dietary AGEs on the mouse liver using bioi...
Source: Molecular Medicine Reports - January 26, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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