Filtered By:
Source: Molecular Medicine Reports
This page shows you your search results in order of date. This is page number 15.
Order by Relevance | Date
Total 425 results found since Jan 2013.
Effects of varying radiation dosages on MMP1 expression, and MMP1 knockdown on the viability and migration of SW620 cells.
Authors: Ju F, Li N, Wang W, Yuan H
Abstract
Colorectal cancer (CRC), also known as bowel cancer, is one of the leading causes of cancer‑associated mortality worldwide at present. The aim of the present study was to detect the effects of matrix metalloproteinase 1 (MMP1) on the viability and migration of a CRC cell line in the presence or absence of variation X‑ray radiation doses. The CRC cell line, SW620, was cultured and treated with different X‑ray doses (0, 0.1, 0.5, 1, 3 and 6 Gy). MMP1 expression was downregulated via the application of a specific small interfering (si)‑RNA. The viability and migra...
Source: Molecular Medicine Reports - February 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
LncRNA ‑NEF is involved the regulation of gastric carcinoma cell proliferation by targeting RUNX1.
LncRNA‑NEF is involved the regulation of gastric carcinoma cell proliferation by targeting RUNX1.
Mol Med Rep. 2019 Jan 16;:
Authors: Wang X, Jiang X, Zhou L, Wang Z, Huang H, Wang M
Abstract
Neighboring enhancer of FOXA2 (NEF) is a newly discovered long non‑coding RNA (lncRNA) that serves an oncogenic function in the metastasis of hepatocellular carcinoma, while its involvement in other types of cancer and in tumor cell proliferation remain unknown. In the present study, tumor tissues and adjacent healthy tissues were obtained from patients with gastric carcinoma, and blood was extracted from pati...
Source: Molecular Medicine Reports - January 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Bioinformatics analysis of sex differences in arrhythmogenic right ventricular cardiomyopathy.
Authors: Chen LT, Jiang CY
Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease that exhibits sex differences on clinical presentation. The present study aimed to investigate the sex differences associated with ARVC by conducting an integrated bioinformatics analysis. The GSE29819 gene expression dataset was downloaded from the Gene Expression Omnibus database. The online analytical tool GEO2R was then used to screen for differentially expressed genes (DEGs), which were subsequently processed using enrichment analysis and protein‑protein interaction (PPI) network construction. F...
Source: Molecular Medicine Reports - January 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Knockdown of ACTA2 ‑AS1 promotes liver cancer cell proliferation, migration and invasion.
Knockdown of ACTA2‑AS1 promotes liver cancer cell proliferation, migration and invasion.
Mol Med Rep. 2019 Jan 15;:
Authors: Zhou RJ, Lv HZ
Abstract
Long noncoding RNAs (lncRNAs) are important regulators of various cellular and biological processes. The present study aimed to investigate the functions of a novel lncRNA, ACTA2‑AS1:4, a transcript variant of smooth muscle α‑actin 2‑antisense 1 (ACTA2‑AS1), in regulating liver cancer progression. Expression of lncRNAs in liver cancer tissues and cell lines were analyzed by reverse transcription quantitative polymerase chain reaction (RT‑qPCR)...
Source: Molecular Medicine Reports - January 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Weighted gene co ‑expression network analysis for identifying hub genes in association with prognosis in Wilms tumor.
Weighted gene co‑expression network analysis for identifying hub genes in association with prognosis in Wilms tumor.
Mol Med Rep. 2019 Jan 21;:
Authors: Wang X, Song P, Huang C, Yuan N, Zhao X, Xu C
Abstract
Wilms tumor (WT) is the most common type of renal malignancy in children. Survival rates are low and high‑risk WT generally still carries a poor prognosis. To better elucidate the pathogenesis and tumorigenic pathways of high‑risk WT, the present study presents an integrated analysis of RNA expression profiles of high‑risk WT to identify predictive molecular biomarkers, for the improvement ...
Source: Molecular Medicine Reports - January 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide ‑induced lung injury.
Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung injury.
Mol Med Rep. 2019 Jan 02;:
Authors: Deng W, Li CY, Tong J, He J, Zhao Y, Wang DX
Abstract
Epithelial sodium channel (ENaC) provides the driving force for the removal of edema from the alveolar spaces in acute lung injury (ALI). Our previous study reported that insulin increased the expression of α‑ENaC, possibly via the serum/glucocorticoid‑inducible kinase‑1 (SGK1) pathway in ALI; however, the upstream regulator of SGK1 activi...
Source: Molecular Medicine Reports - January 12, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Pain polymorphisms and opioids: An evidence based review.
Authors: Vieira CMP, Fragoso RM, Pereira D, Medeiros R
Abstract
Despite the various different candidate genetic polymorphisms of potential clinical relevance, there is not enough understanding of the inter‑individual variability in analgesic administration. The cytochrome P450 2D6 (CYP2D6) genotype is thought to be one of the most studied. The aim of the present evidence‑based review was to determine if there is now sufficient evidence to make clinical recommendations based on a specific genomic profile. The data sources utilized were as follows: PubMed (NLM) database, Evidence Based Medicine Guidelines and Goo...
Source: Molecular Medicine Reports - December 31, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma.
Long non‑coding RNA DLX6‑AS1 is associated with malignant progression and promotes proliferation and invasion in esophageal squamous cell carcinoma.
Mol Med Rep. 2018 Dec 21;:
Authors: Wang M, Li Y, Yang Y, Liu X, Zang M, Li Y, Yang K, Yang W, Zhang S
Abstract
Despite being one of the most prevalent and fatal types of cancer worldwide, the biological details of esophageal squamous cell carcinoma (ESCC) remain unknown. Recent studies have demonstrated the crucial roles of long non‑coding RNAs (lncRNAs) in diverse biological processes including cancer initiation, progression and metastasis. The aim...
Source: Molecular Medicine Reports - December 31, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Bioinformatics analysis of the interactions among lncRNA, miRNA and mRNA expression, genetic mutations and epigenetic modifications in hepatocellular carcinoma.
Authors: Lin C, Yuan G, Hu Z, Zeng Y, Qiu X, Yu H, He S
Abstract
The present study aimed to investigate the regulatory networks involving long noncoding RNA (lncRNA), microRNA (miRNA), mRNA, genetic mutations and epigenetic modifications in hepatocellular carcinoma (HCC) by analyzing datasets from The Cancer Genome Atlas (TCGA) database. TCGA was mined, and miRNAs, lncRNAs and mRNAs that were differentially expressed in HCC were identified using R software. A gene regulatory network was constructed using Cytoscape software. Representative genes were selected for functional enrichment analysis using Gene Ontology an...
Source: Molecular Medicine Reports - December 12, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression via HMGB1 suppression.
Authors: Zhang C, Yu W, Huang C, Ding Q, Liang C, Wang L, Hou Z, Zhang Z
Abstract
High‑mobility group box chromosomal protein (HMGB‑1) contributes to osteoarthritis (OA) by modulating various oxidative, inflammatory and apoptotic signaling pathways. The effect of chrysin (CH), a natural plant flavonoid, and its functional interaction with HMGB‑1, was investigated in a chondrocyte model of OA. Human chondrocytes were pre‑treated with CH, and then subsequently treated with IL‑1β to induce the formation of chondrocytes similar to those found in OA joints. Next, the expression level of HMGB‑1 was determine...
Source: Molecular Medicine Reports - December 12, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Inhibition of lactate dehydrogenase A suppresses inflammatory response in RAW 264.7 macrophages.
Authors: Song YJ, Kim A, Kim GT, Yu HY, Lee ES, Park MJ, Kim YJ, Shim SM, Park TS
Abstract
Lactate is an important metabolite in cellular metabolism and fluctuates in certain disease conditions including cancer and immune diseases. It was hypothesized that a decrease in lactate would modulate the inflammatory response elicited by lipopolysaccharides (LPS) in macrophages. When RAW 264.7 macrophages were treated with FX11, a specific lactate dehydrogenase (LDHA) inhibitor, the expression of the cytokines, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX‑2) was downregulated due to reduced cellular l...
Source: Molecular Medicine Reports - December 1, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Activation of the Notch ‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells.
Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells.
Mol Med Rep. 2018 Nov 09;:
Authors: Jiao W, Ji J, Li F, Guo J, Zheng Y, Li S, Xu W
Abstract
Diabetic retinopathy (DR) occurs in almost all patients with diabetes and remains as one of the major causes of vision loss worldwide. Nevertheless, the molecular mechanisms underlying the pathogenesis of DR remain elusive. The present study aimed to investigate the role and association of Notch signaling and NADPH oxidase 4 (Nox4)‑mediated oxidative stress in...
Source: Molecular Medicine Reports - November 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long noncoding RNA TSLNC8 suppresses cell proliferation and metastasis and promotes cell apoptosis in human glioma.
Authors: Chen D, Yu X
Abstract
Glioma is among the most common primary brain tumors and one of the most aggressive and lethal forms of human cancer. Long noncoding RNAs (lncRNAs) have demonstrated great importance in the development and progression of cancer. The present study aimed to investigate the role of the novel tumor suppressive lncRNA on Chromosome 8p12 (TSLNC8), in cell proliferation, metastasis and apoptosis in human glioma. It was initially reported that the relative transcript levels of TSLNC8 were significantly decreased in human glioma tissues and cultured glioma cells, as evidenced by RT‑qPCR. Amo...
Source: Molecular Medicine Reports - November 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Lentiviral ‑mediated inducible silencing of TLR4 attenuates neuropathic pain in a rat model of chronic constriction injury.
In conclusion, TLR4 may serve a significant role in neuropathy and the results of the present study provide an inducible lentivirus‑mediated siRNA against TLR4 that may serve as a potential novel strategy to be applied in gene therapy for NP in the future.
PMID: 30365084 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 27, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis.
Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis.
Mol Med Rep. 2018 Oct 16;:
Authors: Huang W, Huang L, Wen M, Fang M, Deng Y, Zeng H
Abstract
Sepsis is characterized by systemic inflammatory responses. In the present study, the role of deleted in liver cancer 1 (DILC), interleukin (IL)‑6, signal transducer and activator of transcription 3 (STAT3), and Toll‑like receptor 4 (TLR4) in the pathogenesis of sepsis was investigated. Reverse transcription‑quantitative...
Source: Molecular Medicine Reports - October 27, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
