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Source: Annals of Clinical and Laboratory Science

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Total 13244 results found since Jan 2013.

Unique Hemoglobinopathy Pattern Following Treatment with Voxelotor
CONCLUSIONS: Unique pattern of hemoglobin fractionation analysis following therapy with voxelotor has potential as a tool for the assessment of response and/or compliance to voxelotor for the treatment of SCD.PMID:37625829
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Izmarie Poventud-Fuentes Tania Platero Portillo Lily Olayinka Andrea N Marcogliese Ven ée N Tubman Sridevi Devaraj Source Type: research

C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis
CONCLUSIONS: The low expression of CLEC4G is potentially correlated with LSEC capillarization and the appearance of micro-vessels. Such a phenomenon may serve as a reliable diagnostic marker for hepatocellular carcinoma.PMID:37625828
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Xiang Chen Sheng Li Zui-Ming Jiang Min Gu Bin Feng Zhi-Qin Xie Mei-Yuan Huang Zhu Chen Man-Ling Tang Source Type: research

RBM15-Mediated m6A Modification of K17 Affects Keratinocytes Response to IL-17A Stimulation in Psoriasis
CONCLUSION: This study revealed that RBM15 knockdown suppressed proliferation and inflammation by mediating m6A modification of K17 to reduce K17 stability in IL-17A-induced keratinocytes. Our findings may provide novel idea for improving the treatment of psoriasis.PMID:37625827
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Manni Fu Bei Zhou Nian Shi Rongjing Dong Yongjun Chen Source Type: research

Evaluation of the Alinity hq Automated Hematologic Analyzer and Determination of Reference Ranges for Novel Red Blood Cell Parameters
CONCLUSIONS: The Alinity hq presented good analytical performance and showed good correlation compared with other hematology analyzers and manual differential counts.PMID:37625826
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Seon Young Kim Jimyung Kim Gye Cheol Kwon Source Type: research

< em > Letter to the Editor: < /em > CD1d Expression on Human Monocytes of Adults with Allergic Asthma or Rhinoconjunctivitis
Ann Clin Lab Sci. 2023 Jul;53(4):673-675.NO ABSTRACTPMID:37625825
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Tamar A Smith-Norowitz Jonathan I Silverberg Haram Abdelmajid Rauno Joks Stephan Kohlhoff Source Type: research

Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3
CONCLUSION: Taken together, circ_0038632 promotes breast carcinogenesis through the miR-520a-3p/CDCA3 regulatory cascade, indicating that circ_0038632 may be a potential target for BC treatment.PMID:37625824
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Huayi Zhang Yaqin Zheng Lei Yu Meiya Liu Yongmei Zhang Source Type: research

Suppression of Autophagy Can Augment PIK3 Inhibitor Induced Apoptosis in T Lymphoblastic Leukemia Cell Lines
CONCLUSIONS: The results demonstrated that 3-MA could suppress PI3K inhibitor-mediated activation of autophagy to promote the apoptosis of tumor cells. This discovery provided experimental support for constituting a promising strategy for T-cell acute lymphoblastic leukemia (T-ALL) therapy.PMID:37625845
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Yu Qing Dong Ni Sun Xiang Chou Yang Mu Qing He He Huang Wen Jian Guo Xiao Ji Lin Source Type: research

Linkage of Blood MALT1 with CD4+ T Cell Subset, Inflammation, Lipid, and Its Potency as a Biomarker for Predicting Major Adverse Cardiovascular Events in Coronary Heart Disease Patients
CONCLUSION: Blood MALT1 links with unbalanced CD4+ T-cell subset, elevated inflammation, and coronary-artery stenosis serving as a candidate biomarker for predicting MACE risk in CHD patients.PMID:37625844
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Lina Zhang Jianwei Li Zhijia Yang Shaowei Wang Jinjun Liu Shaohua Luan Gang Tian Source Type: research

A Case of X-Linked Adrenal Hypoplasia Congenital (AHC) Due to Large Deletion of < em > NR0B1 < /em > ( < em > DAX1 < /em > ) and Contiguous Gene
Ann Clin Lab Sci. 2023 Jul;53(4):667-670.ABSTRACTX-linked adrenal hypoplasia congenita (AHC) is caused predominantly by mutations in the NR0B1 (DAX1) gene. Among these, X-linked AHC due to a large deletion of NR0B1 is extremely rare. In Korea, the first case was reported in 2005, and there have been no further documented cases since then. Herein, we report a unique case of X-linked AHC caused by an entire gene deletion that includes the NR0B1 gene and seven other genes. A seven-day-old boy presented to a pediatric endocrine clinic with prolonged postnatal jaundice, skin hyperpigmentation, hyponatremia, and hyperkalemia, su...
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Chungwoo Shin Sung Eun Kim Cheong Jun Moon Il Han Yoo Jisook Yim Won-Kyong Cho Myungshin Kim Jung Hyun Lee Source Type: research

SHP2 Contributes to Resistance of KRAS p.G12C-Driven Lung Cancer Cells to MRTX849 by Regulating β-catenin/c-MYC Axis
CONCLUSION: SHP2 contributes to resistance of KRAS G12C-driven lung cancer cells to MRTX849 by regulating β-catenin/c-MYC axis.PMID:37625842
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Wenli Li Ya Wu Lili Dai Wei Wang Lei Zhao Source Type: research

Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy Resistance for Patients with Hepatocellular Carcinoma
CONCLUSION: CircRNA-SMARCA5 is significantly increased in HCC tissues and promotes radiotherapy resistance. More importantly, higher expression level of cSMARCA5 is related to a poorer 3-year OS for patients with HCC.PMID:37625840
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Zhexing Chang Yuguo Song Fangyue Luo Xinlei Yang Yanqiu Cai Hao Guo Source Type: research

< em > Letter to Editor: < /em > Observations of Deception in Urine Drug Testing
CONCLUSION: Deception can be identified using the metabolite/parent drug ratio.PMID:37625839
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research

Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression
CONCLUSION: This study demonstrated that circ_0088212 impedes OS progression by regulating the miR-576-5p/FKBP1A axis. These findings provide a comprehensive understanding of the role of circ_0088212 in OS tumorigenesis.PMID:37625838
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Xuan Yang Peng Sun Source Type: research

Role of MEG3 in Cellular Physiology of Atherosclerosis
CONCLUSION: Expression of MEG3 is downregulated in the patients with AS and foam cells. Overexpressed MEG3 may act as an anti-atherosclerotic factor by reducing lipid accumulation and accelerating cholesterol efflux through the miR-200b-3p/ABCA1 axis.PMID:37625837
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Yu-Ting Wu Zhi-Jun Guo Jiang-Bin Li Zhi-Rong Ye Guo-Xin Zhang Cong-Min Hong Ming Li Xin-Wen Wang Wei-Feng Xu Guan-Tao Liang Hui-Qin Lin Source Type: research

Elevated Expression of NOP16 as a Novel Prognostic Biomarker of Prostate Cancer
CONCLUSION: NOP16 may be expected to be a novel biomarker for predicting the occurrence and development of PCa, and may become a target for the treatment of PCa.PMID:37625836
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Tong Yang Fengliang Sun Changwen Zhang Zhen Wang Kuo Yang Yong Xu Qian Liu Source Type: research