Filtered By:
Source: Annals of Clinical and Laboratory Science

This page shows you your search results in order of date. This is page number 17.

Order by Relevance | Date

Total 13244 results found since Jan 2013.

SHP2 Contributes to Resistance of KRAS p.G12C-Driven Lung Cancer Cells to MRTX849 by Regulating β-catenin/c-MYC Axis
CONCLUSION: SHP2 contributes to resistance of KRAS G12C-driven lung cancer cells to MRTX849 by regulating β-catenin/c-MYC axis.PMID:37625842
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Wenli Li Ya Wu Lili Dai Wei Wang Lei Zhao Source Type: research

Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy Resistance for Patients with Hepatocellular Carcinoma
CONCLUSION: CircRNA-SMARCA5 is significantly increased in HCC tissues and promotes radiotherapy resistance. More importantly, higher expression level of cSMARCA5 is related to a poorer 3-year OS for patients with HCC.PMID:37625840
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Zhexing Chang Yuguo Song Fangyue Luo Xinlei Yang Yanqiu Cai Hao Guo Source Type: research

< em > Letter to Editor: < /em > Observations of Deception in Urine Drug Testing
CONCLUSION: Deception can be identified using the metabolite/parent drug ratio.PMID:37625839
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Agnes Cua Kevin Krock Richard Thomas Amadeo Pesce Source Type: research

Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression
CONCLUSION: This study demonstrated that circ_0088212 impedes OS progression by regulating the miR-576-5p/FKBP1A axis. These findings provide a comprehensive understanding of the role of circ_0088212 in OS tumorigenesis.PMID:37625838
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Xuan Yang Peng Sun Source Type: research

Role of MEG3 in Cellular Physiology of Atherosclerosis
CONCLUSION: Expression of MEG3 is downregulated in the patients with AS and foam cells. Overexpressed MEG3 may act as an anti-atherosclerotic factor by reducing lipid accumulation and accelerating cholesterol efflux through the miR-200b-3p/ABCA1 axis.PMID:37625837
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Yu-Ting Wu Zhi-Jun Guo Jiang-Bin Li Zhi-Rong Ye Guo-Xin Zhang Cong-Min Hong Ming Li Xin-Wen Wang Wei-Feng Xu Guan-Tao Liang Hui-Qin Lin Source Type: research

Elevated Expression of NOP16 as a Novel Prognostic Biomarker of Prostate Cancer
CONCLUSION: NOP16 may be expected to be a novel biomarker for predicting the occurrence and development of PCa, and may become a target for the treatment of PCa.PMID:37625836
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Tong Yang Fengliang Sun Changwen Zhang Zhen Wang Kuo Yang Yong Xu Qian Liu Source Type: research

miR-152-3p Inhibits Proliferation, Invasion and Autophagy in UMUC3 and TCCSUP Bladder Cancer Cell Lines via Suppressing HMGA2 Expression
CONCLUSION: miR-152-3p inhibited malignant phenotype of bladder cancer cell lines via suppressing HMGA2 expression.PMID:37625835
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Shouchun Li Minjie Pan Xiaopeng Wu Yu Bai Minjun Qi Jiasheng Chen Li Zuo Source Type: research

Acyl-CoA Medium-Chain Synthetase-3 (ACSM3) Is Regulated by Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) and Inhibits Proliferation, Motility and Stem Cell Properties of Breast Invasive Carcinoma
CONCLUSION: We found that ACSM3 was regulated by IGF2BP3 and attenuated BRCA proliferation, invasion and stem cell properties. The role of ACSM3 in BRCA was first revealed, which provides a novel target for treatment.PMID:37625834
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Wenjing Zhu Xiuxing Wei Meijiao Fang Source Type: research

miR-122-3p Alleviates LPS-Induced Pyroptosis of Macrophages via Targeting NLRP1
CONCLUSIONS: These results confirmed that miR-122-3p plays a crucial role in the inhibition of sepsis by suppressing macrophage pyroptosis in an NLRP1-dependent manner. Therefore, miR-122-3p presents as a promising therapeutic target for sepsis.PMID:37625833
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Min Li Longhui Hu Qiao Ke Chujun Ruan Xiaoran Liu Source Type: research

Benign Biphasic Tumors of the Mullerian Tract - a Mimic of Phyllodes Tumor. A Clinical-Pathologic Description of 21 Cases
CONCLUSION: This series adds to the growing body of literature affirming the existence of benign biphasic Mullerian polyps encountered in the endometrium and cervix that fall short of the Mullerian adenosarcoma diagnosis.PMID:37625832
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Jonathan Wawire C James Sung M Ruhul Quddus Source Type: research

Histopathologic "Evolution" in Pediatric Primary Intracranial High-Grade Sarcoma - a Key that Unlocked the Correct Diagnosis
We present a case of a 13-year-old female with a right-sided frontal hemorrhagic mass. Pathological work-up revealed an intra-cranial high-grade sarcoma, not otherwise specified (NOS). Despite receiving chemo-radiation, the lesion recurred after 9 months. This time, the sarcoma had evolved, showing distinct focal rhabdomyoblastic differentiation. Next-generation sequencing (NGS) based assay revealed variants p.E1705V, p.Y1417Ter in DICER1, and other mutations in KRAS and TP53 genes. The lesion was then diagnosed as spindle cell sarcoma with rhabdomyosarcoma-like features, DICER1 mutant. We propose that upfront molecular st...
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Udit Naik Manish Shah David I Sandberg Rohan Samant Angshumoy Roy Meenakshi Bidwai Bhattacharjee Source Type: research

LipidR - a Commentary on a Lipidomics Software Platform Useful for Potential Liquid Biopsies Data Analysis
Ann Clin Lab Sci. 2023 Jul;53(4):503-506.ABSTRACTLipidR is a recent software platform that uses R. This commentary briefly reviews the data published in the literature using this new tool for data mining and analyzing lipidomics datasets. This software is maintained by the R Foundation specifically for Statistical Computing. The R language is widely used among statisticians and data miners for developing statistical software and data analysis. LipidR is a novel open-source R package with enormous functionalities. LipidR filled three significant gaps in lipidomics. First, LipidR has the potential to mine public lipidomics d...
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Fan Shen Consolato M Sergi Source Type: research

Unique Hemoglobinopathy Pattern Following Treatment with Voxelotor
CONCLUSIONS: Unique pattern of hemoglobin fractionation analysis following therapy with voxelotor has potential as a tool for the assessment of response and/or compliance to voxelotor for the treatment of SCD.PMID:37625829
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Izmarie Poventud-Fuentes Tania Platero Portillo Lily Olayinka Andrea N Marcogliese Ven ée N Tubman Sridevi Devaraj Source Type: research

C-type Lectin Domain Family 4 Member G (CLEC4G) Is a Negative Marker for CD34 in the Evolution of Liver Pathogenesis
CONCLUSIONS: The low expression of CLEC4G is potentially correlated with LSEC capillarization and the appearance of micro-vessels. Such a phenomenon may serve as a reliable diagnostic marker for hepatocellular carcinoma.PMID:37625828
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Xiang Chen Sheng Li Zui-Ming Jiang Min Gu Bin Feng Zhi-Qin Xie Mei-Yuan Huang Zhu Chen Man-Ling Tang Source Type: research

RBM15-Mediated m6A Modification of K17 Affects Keratinocytes Response to IL-17A Stimulation in Psoriasis
CONCLUSION: This study revealed that RBM15 knockdown suppressed proliferation and inflammation by mediating m6A modification of K17 to reduce K17 stability in IL-17A-induced keratinocytes. Our findings may provide novel idea for improving the treatment of psoriasis.PMID:37625827
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Manni Fu Bei Zhou Nian Shi Rongjing Dong Yongjun Chen Source Type: research