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Viruses, Vol. 12, Pages 1189: Are Viral Vectors Any Good for RNAi Antiviral Therapy?
m RNA interference (RNAi) represents a novel approach for alternative antiviral therapy. However, issues related to RNA delivery and stability have presented serious obstacles for obtaining good therapeutic efficacy. Viral vectors are capable of efficient delivery of RNAi as short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA). Efficacy in gene silencing for therapeutic applications against viral diseases has been demonstrated in various animal models. Rotavirus (RV) miR-7 can inhibit rotavirus replication by targeting the RV nonstructural protein 5. Viral gene silencing by targeting the RNAi ...
Source: Viruses - October 20, 2020 Category: Virology Authors: Kenneth Lundstrom Tags: Editorial Source Type: research

Retinoic acid receptor β, a potential therapeutic target in the inhibition of adenovirus replication
In this study, a time-course transcriptome analysis of HAdV-infected human lung epithelial cells (A549 cells) was performed to investigate virus–host interactions, and several key host molecules involved in the HAdV infection process were identified. The RARβ (retinoic acid receptor β) molecule, one of the upstream regulatory factors of differentially expressed genes (DEGs), played important roles in HAdV replication. The results of reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting showed that RARβ mRNA and protein were downregulated by HAdV infection in the A549 cells. The knockdown of...
Source: Antiviral Therapy - February 6, 2018 Category: Virology Source Type: research

Enhanced suppression of adenovirus replication by triple combination of anti-adenoviral siRNAs, soluble adenovirus receptor trap sCAR-Fc and cidofovir
Publication date: August 2015 Source:Antiviral Research, Volume 120 Author(s): Tanja Pozzuto , Carsten Röger , Jens Kurreck , Henry Fechner Adenoviruses (Ad) generally induce mild self-limiting respiratory or intestinal infections but can also cause serious disease with fatal outcomes in immunosuppressed patients. Antiviral drug therapy is an important treatment for adenoviral infections but its efficiency is limited. Recently, we have shown that gene silencing by RNA interference (RNAi) is a promising new approach to inhibit adenoviral infection. In the present in vitro study, we examined whether the efficiency of an R...
Source: Antiviral Therapy - June 2, 2015 Category: Virology Source Type: research

Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery
Publication date: June 2012 Source:Antiviral Research, Volume 94, Issue 3 Author(s): Doris Kneidinger , Mirza Ibrišimović , Thomas Lion , Reinhard Klein Human adenoviruses are a common threat to immunocompromised patients, e.g., HIV-positive individuals or solid-organ and, in particular, allogeneic stem cell transplant recipients. Antiviral drugs have a limited effect on adenoviruses, and existing treatment modalities often fail to prevent fatal outcome. Silencing of viral genes by short interfering RNAs (siRNAs) holds a great promise in the treatment of viral infections. The aim of the present study was to identify ad...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research