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Role of the NRP-1-mediated VEGFR2-independent pathway on radiation sensitivity of non-small cell lung cancer cells.
CONCLUSIONS: We demonstrated that when VEGFR2 was inhibited, NRP-1 appeared to regulate RAD51 expression through the VEGFR2-independent ABL-1 pathway, consequently regulating radiation sensitivity. In addition, the combined inhibition of VEGFR2 and NRP-1 appears to sensitize cancer cells to radiation. PMID: 29777301 [PubMed - indexed for MEDLINE]
Source: Clinical Lung Cancer - June 30, 2018 Category: Cancer & Oncology Authors: Hu C, Zhu P, Xia Y, Hui K, Wang M, Jiang X Tags: J Cancer Res Clin Oncol Source Type: research

Role of the NRP-1-mediated VEGFR2-independent pathway on radiation sensitivity of non-small cell lung cancer cells
ConclusionsWe demonstrated that when VEGFR2 was inhibited, NRP-1 appeared to regulate RAD51 expression through the VEGFR2-independent ABL-1 pathway, consequently regulating radiation sensitivity. In addition, the combined inhibition of VEGFR2 and NRP-1 appears to sensitize cancer cells to radiation.
Source: Journal of Cancer Research and Clinical Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

Abstract 3937: Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer
Conclusions: Radiation-induced up-regulation of Notch pathway and HIF-1α might provide therapeutic targets for more effective radiation therapy in NSCLC. Citation Format: Yasuyuki Ikezawa, Jun Sakakibara-Konishi, Hidenori Mizugaki, Satoshi Oizumi, Masaharu Nishimura. Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3937. doi:10.1158/1538-7445.AM2014-3937
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ikezawa, Y., Sakakibara-Konishi, J., Mizugaki, H., Oizumi, S., Nishimura, M. Tags: Tumor Biology Source Type: research

Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
Abstract: Radiotherapy is routinely used for the treatment of lung cancer. However, the mechanisms underlying ionizing radiation (IR)-induced senescence and its role in lung cancer treatment are poorly understood. Here, we show that IR suppresses the proliferation of human non-small cell lung cancer (NSCLC) cells via an apoptosis-independent mechanism. Further investigations reveal that the anticancer effect of irradiation correlates well with IR-induced premature senescence, as evidenced by increased senescence-associated β-glactosidase (SA-β-gal) staining, decreased BrdU incorporation and elevated expression of p16INK4...
Source: Lung Cancer - May 20, 2013 Category: Cancer & Oncology Authors: Hongmei Luo, Caroline Yount, Hainan Lang, Aimin Yang, Ellen C. Riemer, Katherine Lyons, Kenneth N. Vanek, Gerard A. Silvestri, Bradley A. Schulte, Gavin Y. Wang Tags: Carcinogenesis and molecular biology Source Type: research