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Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and  mechanism in gastric cancer cell growth and metastasis.
CONCLUSION: Collectively, our study highlights that the high expression of miR-27a indicates the poor efficacy and prognosis of neoadjuvant chemotherapy in GC patients. Down-regulation of miR-27a can inhibit the growth and metastasis of GC cells via up-regulation of SFRP1. PMID: 30902884 [PubMed - as supplied by publisher]
Source: Bioscience Reports - March 21, 2019 Category: Biomedical Science Authors: Xu C, Cheng H, Li N, Zhou N, Tang X Tags: Biosci Rep Source Type: research

Pretreatment TACC3 expression in locally advanced rectal cancer decreases the response to neoadjuvant chemoradiotherapy.
In this study, we investigated whether TACC3 could serve as a biomarker predictive of the efficacy of chemoradiotherapy. In all, 152 rectal cancer patients with tumor tissue collected at biopsy and set aside before treatment were enrolled in this study. All patients received chemoradiotherapy and surgical resection. Immunohistochemically detected tumoral TACC3 expression significantly decreased sensitivity to chemoradiotherapy [risk ratio (RR) = 2.236, 95% confidence interval (CI): 1.447-3.456; P = 0.001] and thus the pathological complete response rate (P = 0.001). TACC3 knockdown using specific siRNA enhanced radiotherap...
Source: Aging - October 19, 2018 Category: Biomedical Science Authors: Ma WJ, Gu YK, Peng JH, Wang XC, Yue X, Pan ZZ, Chen G, Xu HN, Zhou ZG, Zhang RX Tags: Aging (Albany NY) Source Type: research