• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.
Abstract The main aim of this study was to investigate a possible functional connection between sigma-1 receptors and voltage-gated sodium channels (VGSCs) in human breast cancer cells. The hypothesis was that sigma-1 drugs could alter the metastatic properties of breast cancer cells via the VGSC. Evidence was found for expression of sigma-1 receptor and neonatal Nav1.5 (nNav1.5) expression in both MDA-MB-231 and MDA-MB-468 cells. Sigma-1 drugs (SKF10047 and dimethyltryptamine) did not affect cell proliferation or migration but significantly reduced adhesion to the substrate. Silencing sigma-1 receptor expression ...
Source: European Biophysics Journal : EBJ - May 8, 2016 Category: Physics Authors: Aydar E, Stratton D, Fraser SP, Djamgoz MB, Palmer C Tags: Eur Biophys J Source Type: research

The miR-15 Family Enhances the Radiosensitivity of Breast Cancer Cells by Targeting G2 Checkpoints.
Abstract Enhancing radiosensitivity is an important area of investigation for improving breast cancer therapy outcomes. The aim of this study was to assess the role of the miR-15 family in the radiosensitivity of breast cancer cells. MicroRNAs (miRNAs) encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 (BCL-2) gene. However, the effect of the miR-15 family on G2/M arrest and radiosensitivity remains poorly understood. In the current study, cells transfected with miR-15a/15b/16 mimic or inhibitor were irradiated and examined...
Source: Radiation Research - January 16, 2015 Category: Physics Authors: Mei Z, Su T, Ye J, Yang C, Zhang S, Xie C Tags: Radiat Res Source Type: research

Ionizing Radiation Sensitizes Breast Cancer Cells to Bcl-2 Inhibitor, ABT-737, through Regulating Mcl-1.
Abstract Breast-conserving surgery followed by radiation therapy has become the standard of care for early stage breast cancer. However, there are some patients that develop a local failure. We have previously shown that Bcl-2 overexpression was associated with an increased risk of local recurrence in patients with early stage breast cancer. The purpose of this study was to explore an approach to overcome radiation resistance by targeting pro-survival Bcl-2 family proteins in breast cancer cells. The breast cancer cell lines MCF-7, ZR-75-1 and MDA-MB231 were used in this study. siRNAs were employed to silence myel...
Source: Radiation Research - November 19, 2014 Category: Physics Authors: Wu H, Schiff DS, Lin Y, Neboori HJ, Goyal S, Feng Z, Haffty BG Tags: Radiat Res Source Type: research