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SUMO1 modification stabilizes TET3 protein and increases colorectal cancer radiotherapy sensitivity
CONCLUSIONS: we elucidated the sensitizing role of TET3 protein in the radiation of CRC cells, depending on SUMO1 modification of TET3 at the lysine sites (K479, K758, K1012, K1188, K1397, K1623), in turn stabilizing TET3 expression in the nucleus and subsequently increasing the sensitivity of colorectal cancer to radiotherapy. Together, this study highlights the potentially critical role of TET3 SUMOylation in radiation regulation, which may contribute to an enhanced understanding of the relationship between DNA demethylation and radiotherapy.PMID:37244630 | DOI:10.1016/j.ijrobp.2023.05.037
Source: Health Physics - May 27, 2023 Category: Physics Authors: Fengting Liu Ya Ma Hao Sun Hui Cai Xin Liang Chang Xu Liqing Du Yan Wang Qiang Liu Source Type: research

Extracellular Release of Annexin A2 is Enhanced upon Oxidative Stress Response via the p38 MAPK Pathway after Low-Dose X-Ray Irradiation.
In this study, we found that in cultured human cancer and non-cancerous cells an extracellular release of annexin A2 was greatly enhanced 1-4 h after a single 20 cGy X-ray dose, but not after exposure to ultraviolet C (UVC) radiation. Extracellular release of annexin A2 was also enhanced after H2O2 and nicotine treatments, which was suppressed by pretreatment with the antioxidant, N-acetyl cysteine. Among the oxidative stress pathway molecules examined in HeLa cells, AMP-activated protein kinase α (AMPKα) and p38 mitogen-activated protein kinase (MAPK) were mostly activated by low-dose X-ray radiation, and the p38 MAPK i...
Source: Radiation Research - June 28, 2016 Category: Physics Authors: Kita K, Sugita K, Sato C, Sugaya S, Sato T, Kaneda A Tags: Radiat Res Source Type: research

Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.
Abstract The main aim of this study was to investigate a possible functional connection between sigma-1 receptors and voltage-gated sodium channels (VGSCs) in human breast cancer cells. The hypothesis was that sigma-1 drugs could alter the metastatic properties of breast cancer cells via the VGSC. Evidence was found for expression of sigma-1 receptor and neonatal Nav1.5 (nNav1.5) expression in both MDA-MB-231 and MDA-MB-468 cells. Sigma-1 drugs (SKF10047 and dimethyltryptamine) did not affect cell proliferation or migration but significantly reduced adhesion to the substrate. Silencing sigma-1 receptor expression ...
Source: European Biophysics Journal : EBJ - May 8, 2016 Category: Physics Authors: Aydar E, Stratton D, Fraser SP, Djamgoz MB, Palmer C Tags: Eur Biophys J Source Type: research

Photo-synthesis of protein-based nanoparticles and the application in drug delivery
Publication date: Available online 4 April 2015 Source:Annals of Physics Author(s): Jinbing Xie , Hongyang Wang , Yi Cao , Meng Qin , Wei Wang Recently, protein-based nanoparticles as drug delivery systems have attracted great interests due to the excellent behavior of high biocompatibility and biodegradability, and low toxicity. However, the synthesis techniques are generally costly, chemical reagents introduced, and especially present difficulties in producing homogeneous monodispersed nanoparticles. Here, we introduce a novel physical method to synthesize protein nanoparticles which can be accomplished under physiolog...
Source: Annals of Physics - April 4, 2015 Category: Physics Source Type: research

Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer.
In this study, we investigated the reprogramming of the energy metabolism in radiosensitive and radioresistant head and neck squamous cell carcinomas (HNSCC) using a preclinical matched model of radiation resistance. Our investigation found that radioresistant rSCC-61 cells: 1. They display increased glucose uptake and decreased fatty acid uptake; 2. They deviate from the classical Warburg effect by diverting the glycolytic flux into the pentose phosphate pathway; 3. They are more dependent on glucose than glutamine metabolism to support growth; 4. They have decreased mitochondrial oxidative phosphorylation; 5. They have e...
Source: Radiation Research - March 4, 2015 Category: Physics Authors: Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM Tags: Radiat Res Source Type: research

The miR-15 Family Enhances the Radiosensitivity of Breast Cancer Cells by Targeting G2 Checkpoints.
Abstract Enhancing radiosensitivity is an important area of investigation for improving breast cancer therapy outcomes. The aim of this study was to assess the role of the miR-15 family in the radiosensitivity of breast cancer cells. MicroRNAs (miRNAs) encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 (BCL-2) gene. However, the effect of the miR-15 family on G2/M arrest and radiosensitivity remains poorly understood. In the current study, cells transfected with miR-15a/15b/16 mimic or inhibitor were irradiated and examined...
Source: Radiation Research - January 16, 2015 Category: Physics Authors: Mei Z, Su T, Ye J, Yang C, Zhang S, Xie C Tags: Radiat Res Source Type: research

Ionizing Radiation Sensitizes Breast Cancer Cells to Bcl-2 Inhibitor, ABT-737, through Regulating Mcl-1.
Abstract Breast-conserving surgery followed by radiation therapy has become the standard of care for early stage breast cancer. However, there are some patients that develop a local failure. We have previously shown that Bcl-2 overexpression was associated with an increased risk of local recurrence in patients with early stage breast cancer. The purpose of this study was to explore an approach to overcome radiation resistance by targeting pro-survival Bcl-2 family proteins in breast cancer cells. The breast cancer cell lines MCF-7, ZR-75-1 and MDA-MB231 were used in this study. siRNAs were employed to silence myel...
Source: Radiation Research - November 19, 2014 Category: Physics Authors: Wu H, Schiff DS, Lin Y, Neboori HJ, Goyal S, Feng Z, Haffty BG Tags: Radiat Res Source Type: research

Radiation Enhances the Invasiveness of Irradiated and Nonirradiated Bystander Hepatoma Cells Through a VEGF-MMP2 Pathway Initiated by p53.
Abstract Recent evidence has shown that irradiation can promote the invasiveness of hepatocellular carcinoma cells and have an impact on the invasive behavior of nonirradiated surrounding cancer cells, which may enhance overall tumor aggressiveness. However, the role of the TP53 tumor suppressor gene in the invasion of irradiated hepatoma cells and their nonirradiated bystanders remain largely unknown. In the present study, we found that irradiation increased the invasiveness of human hepatoma HepG2 cells, and pretreatment of the cells with SU1498 (an inhibitor of vascular endothelial growth factor receptor 2, VEG...
Source: Radiation Research - September 23, 2013 Category: Physics Authors: He M, Dong C, Ren R, Yuan D, Xie Y, Pan Y, Shao C Tags: Radiat Res Source Type: research