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Specialty: Cardiology
Source: Circulation
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Total 43 results found since Jan 2013.
< em > SOX17 < /em > Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension
CONCLUSIONS: Common PAH risk variants upstream of the SOX17 promoter reduce endothelial SOX17 expression, at least in part, through differential binding of HOXA5 and ROR-α. Reduced SOX17 expression results in disturbed hPAEC function and PAH. Existing drug compounds can reverse the disturbed SOX17 pulmonary endothelial transcriptomic signature.PMID:37066790 | DOI:10.1161/CIRCULATIONAHA.122.061940
Source: Circulation - April 17, 2023 Category: Cardiology Authors: Rachel Walters Eleni Vasilaki Jurjan Aman Chien-Nien Chen Yukyee Wu Olin D Liang Ali Ashek Olivier Dubois Lin Zhao Farah Sabrin In ês Cebola Jorge Ferrer Nicholas W Morrell James R Klinger Martin R Wilkins Lan Zhao Christopher J Rhodes Source Type: research
Genes that Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts
Conclusions: Together, in vivo and in vitro results confirm sex-dependencies in myofibroblast activation pathways and implicate genes that escape X-chromosome inactivation in regulating sex differences in myofibroblast activation and subsequent AVS progression. Our results underscore the importance of considering sex as a biological variable to understand the molecular mechanisms of AVS and help guide sex-based precision therapies.PMID:35000411 | DOI:10.1161/CIRCULATIONAHA.121.054108
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Brian A Aguado Cierra J Walker Joseph C Grim Megan E Schroeder Dilara Batan Brandon J Vogt Andrea Gonzalez Rodriguez Jessica A Schwisow Karen S Moulton Robert M Weiss Donald D Heistad Leslie A Leinwand Kristi S Anseth Source Type: research
Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium
Conclusions: We identify RANGAP1 as a PALMD partner in ECs. Disrupting the PALMD/RANGAP1 complex alters the subcellular localization of RANGAP1 and XPO1, and leads to nuclear arrest of the XPO1 cargoes p53 and p21, accompanied by gene regulatory changes and loss of actin-dependent nuclear resilience. Combined, these consequences of reduced PALMD expression provide a mechanistic underpinning for PALMD's contribution to CAVS pathology.PMID:34636652 | DOI:10.1161/CIRCULATIONAHA.121.054182
Source: Circulation - October 12, 2021 Category: Cardiology Authors: Miguel S áinz-Jaspeado Ross O Smith Oscar Plunde Sven-Christian Pawelzik Yi Jin Sofia Nordling Yindi Ding Pontus Aspenstr öm Marie Hedlund Giulia Bastianello Flora Ascione Qingsen Li Cansaran Saygili Demir Dinesh Fernando Geoffrey Daniel Anders Franco-C Source Type: research
Teprasiran, A Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study
Conclusions: The incidence, severity, and duration of early AKI in high-risk patients undergoing cardiac surgery were significantly reduced following teprasiran administration. A Phase 3 study with a MAKE90 primary outcome which has recently completed enrollment was designed based on these findings (NCT03510897). Clinical Trial Registration: URL: https://clinicaltrials.gov/ Unique Identifier: NCT02610283.PMID:34474590 | DOI:10.1161/CIRCULATIONAHA.120.053029
Source: Circulation - September 3, 2021 Category: Cardiology Authors: Matthias Thielmann David Corteville Gabor Szabo Madhav Swaminathan Andre Lamy Lukas J Lehner Craig D Brown Nicolas Noiseux Mohamed G Atta Elizabeth C Squiers Shai Erlich Daniel Rothenstein Bruce Molitoris C David Mazer Source Type: research
Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging
Conclusions: Our findings establish a pathogenic role for increased Phe levels in cardiac aging, linking plasma Phe levels to cardiac senescence via dysregulated Phe catabolism along a hepatic-cardiac axis. They highlight Phe/PAH modulation as a potential therapeutic strategy for age-associated cardiac impairment.PMID:34162223 | DOI:10.1161/CIRCULATIONAHA.121.054204
Source: Circulation - June 24, 2021 Category: Cardiology Authors: Gabor Czibik Zaineb Mezdari Dogus Murat Altintas Juliette Br éhat Maria Pini Thomas d'Humi ères Tha ïs Delmont Costin Radu Marielle Breau Hao Liang Cecile Martel Azania Abatan Rizwan Sarwar Oph élie Marion Suzain Naushad Yanyan Zhang Maissa Halfaoui N Source Type: research
Regulation of The Methylation and Expression Levels of the BMPR2 Gene by SIN3a As A Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension
Conclusions: Altogether, our study unveiled the protective/beneficial role of SIN3a in pulmonary hypertension. We also identified a novel and distinct molecular mechanism by which SIN3a regulates BMPR2 in hPASMC. Our study also identified lung-targeted SIN3a gene therapy using AAV1 as a new promising therapeutic strategy for treating patients with PAH.PMID:34078089 | DOI:10.1161/CIRCULATIONAHA.120.047978
Source: Circulation - June 3, 2021 Category: Cardiology Authors: Malik Bisserier Prabhu Mathiyalagan Shihong Zhang Firas Elmastour Peter Dorfm üller Marc Humbert Gregory David Sima Tarzami Thomas Weber Fr édéric Perros Yassine Sassi Susmita Sahoo Lahouaria Hadri Source Type: research
The Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Conclusions: Together, these findings suggest that the UPR exerts a protective effect in the setting of PLN R14del cardiomyopathy and that modulation of the UPR might be exploited therapeutically.PMID:33928785 | DOI:10.1161/CIRCULATIONAHA.120.049844
Source: Circulation - April 30, 2021 Category: Cardiology Authors: Dries A M Feyen Isaac Perea-Gil Renee G C Maas Magdalena Harakalova Alexandra A Gavidia Jennifer Arthur Ataam Ting-Hsuan Wu Aryan Vink Jiayi Pei Nirmal Vadgama Albert J Suurmeijer Wouter P Te Rijdt Michelle Vu Prashila L Amatya Maricela Prado Yuan Zhang L Source Type: research
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPAR α Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development
Conclusions: This study explored potential drivers of vein graft inflammation and identified PPARα as a novel potential pharmacologic treatment for this unmet medical need.PMID:33821665 | DOI:10.1161/CIRCULATIONAHA.119.043724
Source: Circulation - April 6, 2021 Category: Cardiology Authors: Julius L Decano Sasha A Singh Cau ê Gasparotto Bueno Lang Ho Lee Arda Halu Sarvesh Chelvanambi Joan T Matamalas Hengmin Zhang Andrew K Mlynarchik Jiao Qiao Amitabh Sharma Shin Mukai Jianguo Wang Daniel G Anderson C Keith Ozaki Peter Libby Elena Aikawa Ma Source Type: research
The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism
Conclusions: The transcription factor MAFF was identified as a novel central regulator of an atherosclerosis/CAD relevant liver network. MAFF triggered context specific expression of LDLR and other genes known to affect CAD risk. Our results suggest that MAFF is a missing link between inflammation, lipid and lipoprotein metabolism and a possible treatment target.PMID:33626882 | DOI:10.1161/CIRCULATIONAHA.120.050186
Source: Circulation - February 25, 2021 Category: Cardiology Authors: Moritz von Scheidt Yuqi Zhao Thomas Q de Aguiar Vallim Nam Che Michael Wierer Marcus M Seldin Oscar Franz én Zeyneb Kurt Shichao Pang Dario Bongiovanni Masayuki Yamamoto Peter A Edwards Arno Ruusalepp Jason C Kovacic Matthias Mann Johan L M Bj örkegren Source Type: research
