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Role of (Pro)Renin Receptor in Cyclosporin A-Induced Nephropathy
Am J Physiol Renal Physiol. 2022 Jan 24. doi: 10.1152/ajprenal.00332.2021. Online ahead of print.ABSTRACTCalcineurin inhibitors (CNIs) such as cyclosporin A (CsA) have been widely used to improve graft survival following solid-organ transplantation. However, the clinical use of CsA is often limited by its nephrotoxicity. The present study tested the hypothesis that activation of (pro)renin receptor (PRR) contributes to CsA-induced nephropathy by activating the renin-angiotensin system (RAS). Renal injury in male Sprague-Dawley rats was induced by a low-salt diet combined with CsA as evidenced by elevated plasma creatinine ...
Source: American Journal of Physiology. Renal Physiology - January 24, 2022 Category: Physiology Authors: Jiajia Hu Yandan Tan Yanting Chen Shiqi Mo Brittin Hekking Jiahui Su Min Pu Aihua Lu J David Symons Tianxin Yang Source Type: research

Interfering RNA against PKC- α Inhibits TNF-α-induced IP3R1 Expression and Improves Glomerular Filtration Rate in Rats with Fulminant Hepatic Failure.
CONCLUSION: RNAi targeting PKC-α inhibited TNF-α-induced IP3R1 overexpression, and in turn improved compromised GFR in the development of acute kidney injury during FHF in rats. PMID: 29357415 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - January 10, 2018 Category: Physiology Authors: Wang DL, Dai WY, Wang W, Wen Y, Zhou Y, Zhao YT, Wu J, Liu P Tags: Am J Physiol Renal Physiol Source Type: research

P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells.
Abstract Luminal nucleotide stimulation is known to reduce Na(+) transport in the distal nephron. Previous studies suggest that this mechanism may involve the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC), which plays an essential role in NaCl reabsorption in the cells lining the distal convoluted tubule (DCT). Here we show that stimulation of mouse DCT (mDCT) cells with ATP or UTP promoted Ca(2+) transients and decreased the expression of NCC at both mRNA and protein levels. Specific siRNA-mediated silencing of P2Y2 receptors almost completely abolished ATP/UTP-induced Ca(2+) transients and significantly red...
Source: Pflugers Archiv : European Journal of Physiology - January 25, 2014 Category: Physiology Authors: Gailly P, Szutkowska M, Olinger E, Debaix H, Seghers F, Janas S, Vallon V, Devuyst O Tags: Pflugers Arch Source Type: research