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Phosphorus dendrimers as powerful nanoplatforms for drug delivery, as fluorescent probes and for liposome interaction studies: A concise overview.
Abstract Gene therapy is a new and promising tool to treat many severe diseases and the silencing of proteins is the safest and the most efficient tool to treat diseases because it does not induce changes in human genome and avoids a huge problem encompassing insertional mutagenesis. Using small RNAs to switch on/off target proteins is limited due to existence of some barriers for them in the human body (blood RNAses, serum albumins, cell walls, etc). For therapeutic applications they need the efficient and non-toxic carrier which will deliver them into cell cytoplasm. Within the huge range of carriers available, ...
Source: European Journal of Medicinal Chemistry - August 30, 2020 Category: Chemistry Authors: Shcharbin D, Bryszewska M, Mignani S, Shi X, Majoral JP Tags: Eur J Med Chem Source Type: research

A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy
Chem. Commun., 2018, Advance Article DOI: 10.1039/C8CC00931G, CommunicationHuimeng Wang, Lin Zhong, Yang Liu, Xin Xu, Chao Xing, Min Wang, Shu-Meng Bai, Chun-Hua Lu, Huang-Hao Yang A new siRNA delivery platform based on black phosphorus nanosheets is constructed which shows excellent therapy efficiency for tumors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 12, 2018 Category: Chemistry Authors: Huimeng Wang Source Type: research

A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy.
Abstract Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent ...
Source: Chemical Communications - March 12, 2018 Category: Chemistry Authors: Wang H, Zhong L, Liu Y, Xu X, Xing C, Wang M, Bai SM, Lu CH, Yang HH Tags: Chem Commun (Camb) Source Type: research

Black Phosphorus Nanosheets-Based siRNA Delivery System for Synergistic Photothermal and Gene Therapy
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC00931G, CommunicationHuimeng Wang, Lin Zhong, Yang Liu, Xin Xu, Chao Xing, Min Wang, Shumeng Bai, Chun-Hua Lu, Huanghao Yang Gene therapy with small interfering RNA (siRNA) has been proved to be the promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 2, 2018 Category: Chemistry Authors: Huimeng Wang Source Type: research