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Heat-induced manganese-doped magnetic nanocarriers combined with Yap-siRNA for MRI/NIR-guided mild photothermal and gene therapy of hepatocellular carcinoma
Publication date: 15 December 2021Source: Chemical Engineering Journal, Volume 426Author(s): Qian Zhang, Weiyong Zhao, Jin Cheng, Zhoufeng Deng, Ping Zhang, Amin Zhang, Zhi Xu, Shaojun Pan, Xinmei Liao, Daxiang Cui
Source: Chemical Engineering Journal - June 20, 2021 Category: Chemistry Source Type: research

The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels Neurobiology
In this study, we have determined that ZIP8 and ZIP14 (Zrt- and Irt-like proteins 8 and 14) support Mn2+ uptake by BMVECs and that neither DMT1 nor an endocytosis-dependent pathway play any significant role in Mn2+ uptake. Specifically, siRNA-mediated knockdown of ZIP8 and ZIP14 coincided with a decrease in manganese uptake, and kinetic analyses revealed that manganese uptake depends on pH and bicarbonate and is up-regulated by lipopolysaccharide, all biochemical markers of ZIP8 or ZIP14 activity. Mn2+ uptake also was associated with cell-surface membrane presentation of ZIP8 and ZIP14, as indicated by membrane protein bio...
Source: Journal of Biological Chemistry - December 12, 2019 Category: Chemistry Authors: Brittany L. Steimle, Frances M. Smith, Daniel J. Kosman Tags: Cell Biology Source Type: research

MnAl-Layered Double Hydroxide Nanoparticles as a Dual-functional Platform for Magnetic Resonance Imaging and siRNA Delivery.
Abstract Multifunctional nanoparticles for cancer theranosis have been widely explored for effective cancer detection and therapy. In this research, dually functionalised manganese-based layered double hydroxide nanoparticles (Mn-LDHs) have been examined as an effective anticancer drug/gene delivery system and T1-weighted magnetic resonance imaging (MRI) modality for brain cancer theranostics. Such Mn-LDHs have been shown to accommodate dsDNA/siRNAs and efficiently deliver to Neuro-2a cells (N2a). Mn-LDHs have also shown high biocompatibility with low cytotoxicity. Importantly, the cell death-siRNA (CD-siRNA) deli...
Source: Chemistry - August 1, 2017 Category: Chemistry Authors: Zuo H, Chen W, Li B, Xu K, Cooper H, Gu Z, Xu ZP Tags: Chemistry Source Type: research

Manganese, ICAM-1, MCP-1, and Endothelial Cell Dysfunction Molecular Bases of Disease
This study examines the hypothesis that Mn2+ supplementation can reduce the markers/risk factors of endothelial dysfunction in type 2 diabetes. Human umbilical vein endothelial cells (HUVECs) were cultured with or without Mn2+ supplementation and then exposed to high glucose (HG, 25 mm) to mimic diabetic conditions. Mn2+ supplementation caused a reduction in monocyte adhesion to HUVECs treated with HG or MCP-1. Mn2+ also inhibited ROS levels, MCP-1 secretion, and ICAM-1 up-regulation in HUVECs treated with HG. Silencing studies using siRNA against MnSOD showed that similar results were observed in MnSOD knockdown HUVECs fo...
Source: Journal of Biological Chemistry - March 1, 2013 Category: Chemistry Authors: Burlet, E., Jain, S. K. Tags: Metabolism Source Type: research