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Cancer: Skin Cancer

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Total 18 results found since Jan 2013.

Pyrrolidinedione-thiazolidinone hybrid molecules with potent cytotoxic effect in squamous cell carcinoma SCC-15 cells
This study aimed to investigate the cytotoxic effect of three derivatives 1-(4-hydroxyphenyl)-, 1-(4-chlorophenyl)- and 1-(4-bromophenyl)-3-[5-[2-chloro-3-(4-nitrophenyl)prop-2-enylidene]-4-oxo-2-thioxothiazolidine-3-yl]pyrrolidine-2,5-diones (Les-6287, Les-6294, and Les-6328, respectively), their effect on the production of the reactive oxygen species (ROS), apoptosis induction, and expression of genes - PPARγ, AHR, and NRFL2 - whose products are important in metabolism in human tongue squamous cell carcinoma cells of SCC-15 line. The results of resazurin reduction and lactate dehydrogenase (LDH) release assays proved th...
Source: Bioorganic and Medicinal Chemistry - August 14, 2023 Category: Chemistry Authors: Nataliya Finiuk Edyta Kaleniuk Serhii Holota Rostyslav Stoika Roman Lesyk Konrad A Szychowski Source Type: research

Advances in chitosan-based drug delivery systems in melanoma: A narrative review
Curr Med Chem. 2023 May 18. doi: 10.2174/0929867330666230518143654. Online ahead of print.ABSTRACTMelanoma accounts for the minority of skin cancer cases. However, it has the highest mortality rate among the subtypes of skin cancer. At the early stages of the disease, patients show a good prognosis after the surgery, but developing metastases leads to a remarkable drop in patients' 5-year survival rate. Despite the advances made in the therapeutic approaches to this disease, melanoma treatment is still facing several obstacles. Systemic toxicity, water insolubility, instability, lack of proper biodistribution, inadequate c...
Source: Current Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Parisa Maleki Dana Jamal Hallajzadeh Zatollah Asemi Mohammad Ali Mansournia Bahman Yousefi Source Type: research

Histone deacetylase 1 regulates the malignancy of oral cancer cells via miR-154-5p/PCNA axis.
Authors: Lv Y, Lu J, Liu X, Miao S, Li B, Pei R, Xiang C Abstract Histone deacetylases (HDACs) can regulate the progression of various cancers, while their roles in oral cancer cells are not well known. Our present study found that the HDAC1 was over expressed in oral squamous cell carcinoma (OSCC) cells and tissues. Targeted inhibition of HDAC1 via its specific inhibitor PCI24781 or siRNA can inhibit the proliferation of OSCC cells and increase their sensitivity to the chemo-sensitivity such as doxorubicin (Dox) treatment. HDAC1 can regulate the expression of proliferating cell nuclear antigen (PCNA) via decreasin...
Source: Biological Chemistry - June 20, 2020 Category: Chemistry Tags: Biol Chem Source Type: research

Homologous-targeting biomimetic nanoparticles for photothermal therapy and Nrf2-siRNA amplified photodynamic therapy against oral tongue squamous cell carcinoma
Publication date: 15 May 2020Source: Chemical Engineering Journal, Volume 388Author(s): Shurui Shi, Yue Wang, Beibei Wang, Qian Chen, Guoyun Wan, Xiaoying Yang, Juan Zhang, Lianyun Zhang, Changyi Li, Yinsong WangAbstractPhotothermal therapy (PTT) and photodynamic therapy (PDT) have some advantages such as site selectivity, non- or little-invasive property and negligible drug resistance for treatment of oral tongue squamous cell carcinoma (OTSCC). However, the activation of intracellular antioxidant responses will partly counteract anticancer effects of PDT. As a well-known redox-regulated transcription factor, Nrf2 has bee...
Source: Chemical Engineering Journal - February 5, 2020 Category: Chemistry Source Type: research

Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells Microbiology
Cytoplasmic dsRNA is recognized by RNA helicase RIG-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), triggering induction of the innate immune response via the mitochondrial antiviral signaling protein (MAVS). In contrast, extracellular dsRNA is internalized into endosomes and recognized by Toll-like receptor 3 (TLR3), which triggers signaling via the Toll-like receptor adaptor molecule 1 (TICAM-1). Poly(I:C) is a synthetic dsRNA analog and increases the expression of octamer-binding protein 3/4 (OCT3/4), NANOG, and SRY-box (SOX) mRNAs during pluripotency induction. However, the mechanism underlying this...
Source: Journal of Biological Chemistry - December 12, 2019 Category: Chemistry Authors: Guanming Wang, Takahisa Kouwaki, Kazuki Mugikura, Masaaki Okamoto, Hiromi Takaki, Kenji Funami, Tsukasa Seya, Hiroyuki Oshiumi Tags: Immunology Source Type: research

Decreased cytoplasmic X-box binding protein-1 expression is associated with poor prognosis and overall survival in patients with oral squamous cell carcinoma.
CONCLUSION: Our results suggest that XBP-1 expression may play an essential role in the pathogenesis of OSCC and that targeting XBP-1 may be a sound therapeutic strategy. PMID: 29305191 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - January 2, 2018 Category: Chemistry Authors: Hsu HT, Hsing MT, Yeh CM, Chen CJ, Yang JS, Yeh KT Tags: Clin Chim Acta Source Type: research

Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells Cell Biology
The galactoside-binding protein galectin-3 is increasingly recognized as an important player in cancer development, progression, and metastasis via its interactions with various galactoside-terminated glycans. We have shown previously that circulating galectin-3, which is increased up to 30-fold in cancer patients, promotes blood-borne metastasis in an animal cancer model. This effect is partly attributable to the interaction of galectin-3 with unknown receptor(s) on vascular endothelial cells and causes endothelial secretion of several metastasis-promoting cytokines. Here we sought to identify the galectin-3-binding molec...
Source: Journal of Biological Chemistry - May 19, 2017 Category: Chemistry Authors: Florent Colomb, Weikun Wang, Deborah Simpson, Mudaser Zafar, Robert Beynon, Jonathan M. Rhodes, Lu-Gang Yu Tags: Glycobiology and Extracellular Matrices Source Type: research

MDA-7/IL-24 Alters Bcl-x RNA Splicing RNA
Melanoma differentiation-associated gene 7 (MDA-7/IL-24) exhibits cytotoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to efficiently block the induction of cell death by MDA-7/IL-24. The expression of Bcl-x(L) is regulated at the level of RNA splicing via alternative 5′ splice site selection within exon 2 to produce either the pro-apoptotic Bcl-x(s) or the anti-apoptotic Bcl-x(L). Our laboratory previously reported that Bcl-x RNA splicing is dysregulated in a large percentage of human non-small cell lung cancer (NSCLC) tumors. Therefore, we investigated whether the alternative RNA...
Source: Journal of Biological Chemistry - October 6, 2016 Category: Chemistry Authors: Shapiro, B. A., Vu, N. T., Shultz, M. D., Shultz, J. C., Mietla, J. A., Gouda, M. M., Yacoub, A., Dent, P., Fisher, P. B., Park, M. A., Chalfant, C. E. Tags: Signal Transduction Source Type: research

Tumor-derived Thrombin Induces Endothelial Gap Formation Cell Biology
In this study, we investigated the mechanism by which the adhesion of melanoma cells to endothelium regulates adherens junction integrity and modulates tumor transendothelial migration (TEM) by initiating thrombin generation. We found that the B-Raf(V600E) mutation in metastatic melanoma cells up-regulated tissue factor (TF) expression on cell membranes and promoted thrombin production. Co-culture of endothelial monolayers with metastatic melanoma cells mediated the opening of inter-endothelial spaces near melanoma cell contact sites in the presence of platelet-free plasma (PFP). By using small interfering RNA (siRNA), we ...
Source: Journal of Biological Chemistry - January 29, 2016 Category: Chemistry Authors: Zhang, P., Feng, S., Liu, G., Wang, H., Zhu, H., Ren, Q., Bai, H., Fu, C., Dong, C. Tags: Molecular Bases of Disease Source Type: research

miR-101 and miR-217 Silence MALAT1 in ESCC Molecular Bases of Disease
In this study we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated up-regulation of p21 and p27 expression and the inhibition of B-MYB expression. Moreover, we also found the abilities of migration and invasion of ESCC cells were inhibited after overexpression of miR-101, miR-217, or MALAT1 siRNA. This might be attributed to the deregulation of downstream genes of MALAT...
Source: Journal of Biological Chemistry - February 13, 2015 Category: Chemistry Authors: Wang, X., Li, M., Wang, Z., Han, S., Tang, X., Ge, Y., Zhou, L., Zhou, C., Yuan, Q., Yang, M. Tags: RNA Source Type: research

Aurin Causes Lethal Proteotoxic Stress in Melanoma Cells Signal Transduction
Pharmacological induction of proteotoxic stress is rapidly emerging as a promising strategy for cancer cell-directed chemotherapeutic intervention. Here, we describe the identification of a novel drug-like heat shock response inducer for the therapeutic induction of proteotoxic stress targeting malignant human melanoma cells. Screening a focused library of compounds containing redox-directed electrophilic pharmacophores employing the Stress 4-[bis(p-hydroxyphenyl)methylene]-2,5-cyclohexadien-1-one) was identified as an experimental cell stress modulator that causes (i) heat shock factor transcriptional activation, (ii) up-...
Source: Journal of Biological Chemistry - January 16, 2015 Category: Chemistry Authors: Davis, A. L., Qiao, S., Lesson, J. L., Rojo de la Vega, M., Park, S. L., Seanez, C. M., Gokhale, V., Cabello, C. M., Wondrak, G. T. Tags: Cell Biology Source Type: research

Activated MAPK/NRAS Drive Vemurafenib Resistance in Melanoma Cell Biology
Although targeting the V600E activating mutation in the BRAF gene, the most common genetic abnormality in melanoma, has shown clinical efficacy in melanoma patients, response is, invariably, short lived. To better understand mechanisms underlying this acquisition of resistance to BRAF-targeted therapy in previously responsive melanomas, we induced vemurafenib resistance in two V600E BRAF+ve melanoma cell lines, A375 and DM443, by serial in vitro vemurafenib exposure. The resulting approximately 10-fold more vemurafenib-resistant cell lines, A375rVem and D443rVem, had higher growth rates and showed differential collateral r...
Source: Journal of Biological Chemistry - October 2, 2014 Category: Chemistry Authors: Lidsky, M., Antoun, G., Speicher, P., Adams, B., Turley, R., Augustine, C., Tyler, D., Ali-Osman, F. Tags: Molecular Bases of Disease Source Type: research